AAF86322.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
PMEPA1 protein
NCBI Official Synonym Full Names
prostate transmembrane protein, androgen induced 1
NCBI Protein Information
transmembrane prostate androgen-induced protein; solid tumor-associated 1 protein; transmembrane, prostate androgen induced RNA
UniProt Protein Name
Transmembrane prostate androgen-induced protein
UniProt Synonym Protein Names
Solid tumor-associated 1 protein
UniProt Synonym Gene Names
UniProt Entry Name
PMEPA_HUMAN
NCBI Summary for PMEPA1
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for PMEPA1
TMEPAI: Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. Belongs to the PMEPA1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 20q13.31-q13.33
Cellular Component: Golgi membrane; early endosome membrane; plasma membrane; integral to membrane; endosome membrane
Molecular Function: protein binding; WW domain binding
Biological Process: transforming growth factor beta receptor signaling pathway; androgen receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway
Research Articles on PMEPA1
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Products associated with anti-PMEPA1 antibody
Pathways associated with anti-PMEPA1 antibody
Diseases associated with anti-PMEPA1 antibody
Organs/Tissues associated with anti-PMEPA1 antibody
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