Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PML rightarrow Polyclonal PML  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • MAST2 Antibody
 • BCA-1 (CXCL13) Recombinant Protein
 • [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitoc... Recombinant Protein
 • Arginase 1 (ARG1) Antibody
 • NLRP3 Antibody
 • Integrin alpha 2 (ITGA2) Antibody
 • TPS ELISA Kit
 • Caspase-3 ELISA Kit
 • Wnt5a Antibody
 • Thrombopoietin receptor (TPOR) Recombinant Protein
 • S1PR1 Antibody
 • Iron Responsive Element Binding Protein 2 (IREB2) ELISA Kit
 • Myosin regulatory light chain 2 (MYLPF) Antibody
 • Claudin 4 (CLDN4) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PML antibody :: Rabbit anti-Human PML Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2536298
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PML, Polyclonal Antibody

★Popular Item★
 Also Known As   

PML Polyclonal Antibody

 Product Synonym Names    PML; MYL; RNF71; TRIM19; Protein PML; Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19
 Product Gene Name   

anti-PML antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    102578
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
Section Bar
 Immunogen    Synthesized peptide derived from the N-terminal region of human PML.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9862 / sc-9863 / sc-5621
Section Bar
 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PML antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-PML antibody    Cancer; Epigenetics
 Applications Tested/Suitable for anti-PML antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-PML antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000
Section Bar
 Western Blot (WB) of anti-PML antibody    Western Blot analysis of A549 cells using PML Polyclonal Antibody at dilution of 1:1000.
anti-PML antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PML. It may not necessarily be applicable to this product.
 NCBI GI #    4505903
 NCBI GeneID    5371
 NCBI Accession #    NP_002666.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002675.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; E9PBR7 [Other Products]
 UniProt Related Accession #    P29590 [Other Products]
 Molecular Weight    Calculated MW: 98
Observed MW: 98
Table BarTOPTable Bar
 NCBI Official Full Name    protein PML isoform 6
 NCBI Official Synonym Full Names    promyelocytic leukemia
 NCBI Official Symbol    PML [Similar Products]
 NCBI Official Synonym Symbols   
MYL; RNF71; PP8675; TRIM19
[Similar Products]
 NCBI Protein Information    protein PML
 UniProt Protein Name    Protein PML
 UniProt Synonym Protein Names   
Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19
 Protein Family    Protein
 UniProt Gene Name    PML [Similar Products]
 UniProt Synonym Gene Names    MYL; PP8675; RNF71; TRIM19 [Similar Products]
 UniProt Entry Name    PML_HUMAN
Section Bar
 NCBI Summary for PML    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for PML    Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration.
Table BarTOPTable Bar
 Research Articles on PML    1. The present study constitutes evidence that PML contributes to a cellular antiviral response and restricts Dengue virus, DENV-2 replication in human A549 cells.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-PML antibodyPathways associated with anti-PML antibody
 Reference Product  PubMed Publications
 RARA antibody  >468 publications with PML and RARA
 SUMO1 antibody  >194 publications with PML and SUMO1
 SP100 antibody  >178 publications with PML and SP100
 MDM2 antibody  >42 publications with PML and MDM2
 TP53 antibody  >37 publications with PML and TP53
 SUMO2 antibody  >32 publications with PML and SUMO2
 RNF4 antibody  >27 publications with PML and RNF4
 SUMO3 antibody  >16 publications with PML and SUMO3
 UBC antibody  >1 publications with PML and UBC
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-PML antibodyOrgans/Tissues associated with anti-PML antibody
 Disease Name  Pubmed Publications
 Leukemia, Promyelocytic, Acute Antibodies  >1695 publications with PML and Leukemia, Promyelocytic, Acute
 Cell Transformation, Neoplastic Antibodies  >160 publications with PML and Cell Transformation, Neoplastic
 Inflammation Antibodies  >89 publications with PML and Inflammation
 Necrosis Antibodies  >82 publications with PML and Necrosis
 Heart Diseases Antibodies  >75 publications with PML and Heart Diseases
 Liver Diseases Antibodies  >73 publications with PML and Liver Diseases
 Lung Diseases Antibodies  >64 publications with PML and Lung Diseases
 Kidney Diseases Antibodies  >46 publications with PML and Kidney Diseases
 Neoplasms, Experimental Antibodies  >43 publications with PML and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >40 publications with PML and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >988 publications with PML and Blood
 Brain Antibodies  >960 publications with PML and Brain
 Bone Antibodies  >496 publications with PML and Bone
 Kidney Antibodies  >136 publications with PML and Kidney
 Liver Antibodies  >132 publications with PML and Liver
 Nerve Antibodies  >120 publications with PML and Nerve
 Lung Antibodies  >102 publications with PML and Lung
 Heart Antibodies  >96 publications with PML and Heart
 Skin Antibodies  >72 publications with PML and Skin
 Vascular Antibodies  >60 publications with PML and Vascular
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions