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anti-PPPDE1 antibody :: Rabbit PNAS4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150332
Western Blot (WB)
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PNAS4 (PPPDE1), Polyclonal Antibody

 Also Known As   

PNAS4 Antibody

 Product Synonym Names    PNAS4; DESI; DESI1; DeSI-2; PNAS-4; PPPDE1; CGI-146; FAM152A; C1orf121; Desumoylating isopeptidase 2; PPPDE peptidase domain-containing protein 1; PPPDE peptidase domain containing 1
 Product Gene Name   

anti-PPPDE1 antibody

[Similar Products]
 Antibody/Peptide Pairs    PNAS4 peptide (MBS151804) is used for blocking the activity of PNAS4 antibody (MBS150332)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    614638
 3D Structure    ModBase 3D Structure for Q9BSY9
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    PNAS4 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    PNAS4 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PNAS4.
 Buffer    PNAS4 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    PNAS4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-PPPDE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PPPDE1 antibody

   PNAS4 Antibody: PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.
 Applications Tested/Suitable for anti-PPPDE1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PPPDE1 antibody    PNAS4 antibody can be used for detection of PNAS4 by Western blot at 1 - 2 mug/mL.
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 Western Blot (WB) of anti-PPPDE1 antibody    Western blot analysis of PNAS4 in EL4 cell lysate with PNAS4 antibody at (A) 1 and (B) 2 μg/mL.
anti-PPPDE1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PPPDE1. It may not necessarily be applicable to this product.
 NCBI GI #    38708309
 NCBI GeneID    51029
 NCBI Accession #    NP_057160 [Other Products]
 NCBI GenBank Nucleotide #    NM_016076.4 [Other Products]
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 UniProt Primary Accession #    Q9BSY9 [Other Products]
 UniProt Secondary Accession #    Q5VVC6; Q9NYS2; Q9Y3E4; B1APK6 [Other Products]
 UniProt Related Accession #    Q9BSY9 [Other Products]
 Molecular Weight    17,808 Da
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 NCBI Official Full Name    desumoylating isopeptidase 2 isoform 1
 NCBI Official Synonym Full Names    desumoylating isopeptidase 2
 NCBI Official Symbol    DESI2 [Similar Products]
 NCBI Official Synonym Symbols   
DESI; DESI1; DeSI-2; PNAS-4; PPPDE1; CGI-146; FAM152A; C1orf121
[Similar Products]
 NCBI Protein Information    desumoylating isopeptidase 2; desumoylating isopeptidase 1; PPPDE peptidase domain-containing protein 1; family with sequence similarity 152, member A
 UniProt Protein Name    Desumoylating isopeptidase 2
 UniProt Synonym Protein Names   
PPPDE peptidase domain-containing protein 1; Protein FAM152A
 UniProt Gene Name    DESI2 [Similar Products]
 UniProt Synonym Gene Names    C1orf121; FAM152A; PPPDE1; DeSI-2 [Similar Products]
 UniProt Entry Name    DESI2_HUMAN
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 UniProt Comments for PPPDE1    PPPDE1: Protease which may deconjugate SUMO from some substrate proteins. Belongs to the DeSI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.-.-

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: cytoplasm

Molecular Function: peptidase activity

Biological Process: proteolysis
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 Research Articles on PPPDE1    1. hPNAS-4 inhibits proliferation of ovarian cancer cells by inducing S phase arrest and apoptosis via activation of Cdc25A-Cdk2-Cyclin E/Cyclin A axis and mitochondrial dysfunction-mediated caspase-dependent and -independent apoptotic pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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