BC033822
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,004 Da
NCBI Official Full Name
Homo sapiens polynucleotide kinase 3'-phosphatase, mRNA
NCBI Official Synonym Full Names
polynucleotide kinase 3'-phosphatase
NCBI Protein Information
bifunctional polynucleotide phosphatase/kinase
UniProt Protein Name
Bifunctional polynucleotide phosphatase/kinase
UniProt Synonym Protein Names
DNA 5'-kinase/3'-phosphatase; Polynucleotide kinase-3'-phosphataseIncluding the following 2 domains:Polynucleotide 3'-phosphatase (EC:3.1.3.32)Alternative name(s):2'(3')-polynucleotidase
NCBI Summary for PNKP
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]
UniProt Comments for PNKP
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.
Product References and Citations for anti-PNKP antibody
(1) Della-Maria, J., Hegde, M.L., McNeill, D.R. et al. The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. J. Biol. Chem. 287 (46), 39233-39244 (2012).
Research Articles on PNKP
Precautions
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Products associated with anti-PNKP antibody
Diseases associated with anti-PNKP antibody
Organs/Tissues associated with anti-PNKP antibody
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