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anti-PNMT antibody :: Guinea Pig PNMT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534453 anti-PNMT antibody
Unit / Price
0.05 mL  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PNMT, Polyclonal Antibody

 Also Known As   

PNMT antibody

 Product Synonym Names    Polyclonal PNMT; Anti-PNMT; Phenylethanolamine-N-methyltransferase
 Product Gene Name   

anti-PNMT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    171190
 3D Structure    ModBase 3D Structure for P11086
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 Clonality    Polyclonal
 Isotype    IgG1
 Host    Guinea Pig
 Species Reactivity    Rat  Positive control: DEPC-fixed paraffin sections of Rat adrenal gland
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 Specificity    Bovine PNMT
 Purity/Purification    Whole antiserum
 Form/Format    Supplied as a lyophilized powder. Dissolve the antiserum in 50 - 100 ul distilled water, and dilute further in 0.1M PBS with 1% BSA and 0.1% NaN3.
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 Biological Significance    Phenylethanolamine-N-methyltransferase (PNMT) is an enzyme converting noradrenaline to adrenaline. The enzyme is present in adrenomedullary cells and in the brain neurons. Absorption with 10-100 ug immunogen per ml diluted antiserum abolishes the staining.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    PNMT antibody was raised in guinea pig using phenylethanolamine-N-methyltransferase from bovine adrenal medulla as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-PNMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PNMT antibody

   Guinea Pig polyclonal PNMT antibody
 Product Categories/Family for anti-PNMT antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-PNMT antibody   

Immunohistochemistry (IHC) Formalin/Paraffin

 Application Notes for anti-PNMT antibody    IHC-F: 1:400-1:800
IHC-P: 1:400-1:800
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NCBI/Uniprot data below describe general gene information for PNMT. It may not necessarily be applicable to this product.
 NCBI GI #    4505921
 NCBI GeneID    5409
 NCBI Accession #    NP_002677.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002686.3 [Other Products]
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 UniProt Primary Accession #    P11086 [Other Products]
 UniProt Related Accession #    P11086 [Other Products]
 Molecular Weight    30,855 Da
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 NCBI Official Full Name    phenylethanolamine N-methyltransferase
 NCBI Official Synonym Full Names    phenylethanolamine N-methyltransferase
 NCBI Official Symbol    PNMT [Similar Products]
 NCBI Official Synonym Symbols   
PENT; PNMTase
[Similar Products]
 NCBI Protein Information    phenylethanolamine N-methyltransferase
 UniProt Protein Name    Phenylethanolamine N-methyltransferase
 UniProt Synonym Protein Names   
Noradrenaline N-methyltransferase
 Protein Family    Phenylethanolamine N-methyltransferase
 UniProt Gene Name    PNMT [Similar Products]
 UniProt Synonym Gene Names    PENT; PNMTase [Similar Products]
 UniProt Entry Name    PNMT_HUMAN
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 NCBI Summary for PNMT    The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
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 UniProt Comments for PNMT    PNMT: Converts noradrenaline to adrenaline. Belongs to the NNMT/PNMT/TEMT family.

Protein type: Amino Acid Metabolism - tyrosine; EC 2.1.1.28; Methyltransferase

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytosol

Molecular Function: phenylethanolamine N-methyltransferase activity

Biological Process: methylation; catecholamine biosynthetic process; epinephrine biosynthetic process

Disease: Hypertension, Essential
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 Research Articles on PNMT    1. initial velocity studies on human PNMT in the absence and presence of product and dead end inhibitors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PNMT antibodyPathways associated with anti-PNMT antibody
 Reference Product  PubMed Publications
 DBH antibody  >190 publications with PNMT and DBH
 NPY antibody  >40 publications with PNMT and NPY
 COMT antibody  >29 publications with PNMT and COMT
 SP1 antibody  >20 publications with PNMT and SP1
 DDC antibody  >8 publications with PNMT and DDC
 MAOA antibody  >4 publications with PNMT and MAOA
 MAOB antibody  >1 publications with PNMT and MAOB
 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Catecholamine Biosynthesis Pathway antibodies  Catecholamine Biosynthesis Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
Diseases associated with anti-PNMT antibodyOrgans/Tissues associated with anti-PNMT antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >68 publications with PNMT and Hypertension
 Vascular Diseases Antibodies  >62 publications with PNMT and Vascular Diseases
 Disease Models, Animal Antibodies  >27 publications with PNMT and Disease Models, Animal
 Hypotension Antibodies  >14 publications with PNMT and Hypotension
 Pain Antibodies  >12 publications with PNMT and Pain
 Heart Diseases Antibodies  >11 publications with PNMT and Heart Diseases
 Bradycardia Antibodies  >9 publications with PNMT and Bradycardia
 Heart Failure Antibodies  >8 publications with PNMT and Heart Failure
 Movement Disorders Antibodies  >7 publications with PNMT and Movement Disorders
 Kidney Diseases Antibodies  >7 publications with PNMT and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >451 publications with PNMT and Brain
 Adrenal Gland Antibodies  >339 publications with PNMT and Adrenal Gland
 Eye Antibodies  >26 publications with PNMT and Eye
 Thyroid Antibodies  >10 publications with PNMT and Thyroid
 Placenta Antibodies  >2 publications with PNMT and Placenta
 Uterus Antibodies  >2 publications with PNMT and Uterus
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