NP_079501.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,485 Da
NCBI Official Full Name
patatin-like phospholipase domain-containing protein 3
NCBI Official Synonym Full Names
patatin-like phospholipase domain containing 3
NCBI Protein Information
patatin-like phospholipase domain-containing protein 3; adiponutrin; iPLA2epsilon; iPLA2-epsilon; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon
UniProt Protein Name
Patatin-like phospholipase domain-containing protein 3
UniProt Synonym Protein Names
Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon
UniProt Synonym Gene Names
UniProt Entry Name
PLPL3_HUMAN
NCBI Summary for PNPLA3
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for PNPLA3
PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - glycerolipid; Transferase; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation; Phospholipase; Amino Acid Metabolism - tyrosine; Membrane protein, integral; EC 3.1.1.3; Amino Acid Metabolism - phenylalanine
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane
Molecular Function: phospholipase A2 activity; triacylglycerol lipase activity; mono-olein transacylation activity; diolein transacylation activity
Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; triacylglycerol catabolic process; triacylglycerol biosynthetic process
Research Articles on PNPLA3
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Products associated with anti-PNPLA3 antibody
Pathways associated with anti-PNPLA3 antibody
Diseases associated with anti-PNPLA3 antibody
Organs/Tissues associated with anti-PNPLA3 antibody
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