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anti-PNPLA3 antibody :: Rabbit PNPLA3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS544053
Western Blot (WB)
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PNPLA3, Polyclonal Antibody

★Popular Item★
 Also Known As   

PNPLA3 Antibody

 Product Synonym Names    Acylglycerol O acyltransferase, Adiponutrin, ADPN, C22orf20, Calcium independent phospholipase A2 epsilon, IPLA2-epsilon, Patatin like phospholipase domain containing 3 phospholipase A2, calcium independent, epsilon
 Product Gene Name   

anti-PNPLA3 antibody

[Similar Products]
 Matching Pairs    Antibody: PNPLA3 (MBS544053)
Positive Control: PNPLA3 (MBS543144)
 Antibody/Peptide Pairs    PNPLA3 peptide (MBS544298) is used for blocking the activity of PNPLA3 antibody (MBS544053)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609567
 3D Structure    ModBase 3D Structure for Q9NST1
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Bovine, Human, Mouse, Rat
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 Purity/Purification    Immobilized antigen affinity chromatography
 Form/Format    Affinity Purified Immunoglobulins
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 Immunoglobulin & Concentration    0.68 mg/ml IgG in antibody stabilization buffer
 Immunogen    Synthetic peptide taken within amino acid region 150-200 on human Patatin-like phospholipase domain-containing protein 3.
 Expression    By changes in energy balance: down-regulated following very low-calorie diet, whereas refeeding elevates the mRNA level.
 Molecular Function    Phospholipase A2 Activity; Lipid degradation and metabolism; Acyltransferase; Hydrolase; Transferase
 Structure    Contains 1 patatin domain
 Subcellular Location    Membrane; Single-pass type II membrane protein
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 Preparation and Storage    Store at -20C for long term storage.
 Other Notes    Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PNPLA3 antibody

   Patatin-like Phospholiipase Domain Containing protein 3(PNPLA3) is an enzyme that acts as a triacylglycerol lipase.The PNPLA3 activity mediates traiacylclycerol hydrolysis in adipocytes. (1)A nonsynonymous polymorphism in PNPLA3 that is strongly associated with hepatic fat content and with elevated serum levels of alanine aminotransferase and aspartate amino transferase have been identified (2) PNPLA3 genetic variation may contribute to ancestry-related an inter-individual differences in hepatic fat content and susceptibility to NAFLD(3).

The PNPLA3-selective antibodies were generated against a synthetic peptide taken within amino acid region 150-200 on human Patatin-like phospholipase domain-containing protein 3.The PNPLA3 synthetic peptide was covalently modified to achiee desired antigenic properties and was conjugated to a carrier protein before used as a immunogen to raise antibodies in rabbits. The PNPLA3 antibodies are affinity purified over immobilized immunogenic peptide affinity matrix and stabilized with preservatives for long-term storage. Antigenic blocking peptide (P-PNPLA3) and western blot positive controls (PC-PNPLA3 )are available. Antibodies can be conjugated to fluorophores or secondary enzymes upon request at nominal cost.
 Product Categories/Family for anti-PNPLA3 antibody    Primary Antibodies; Cell Biology; Lipids; PNPLA3 Antibody
 Applications Tested/Suitable for anti-PNPLA3 antibody   

ELISA, IP, WB

 Application Notes for anti-PNPLA3 antibody    DOT Blot (DB): 1:20,000
ELISA (EIA): 1:20,000
Immunohistochemistry (IHC): 1:50-1:100
Immunoprecipitation (IP): 1:200
Western Blot (WB): 1:500-1:750
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 Western Blot (WB) of anti-PNPLA3 antibody    WB of PNPLA3 antibody (MBS544053) with:
A. Rat liver
B. Mouse kidney
Antibody dilution 1:500 in DiluOBufferTM (FGI-1963).
Apparent MW of PNPLA3 in rat liver is 58 kDa.
Apparent MW of PNPLA3 in mouse kidney is 52 kDa.

Dilutions are for reference only. Applications not listed above are not necessarily precluded from working with this antibody. Investigators intending to use an application that has not been verified can request a complimentary sample.
anti-PNPLA3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PNPLA3. It may not necessarily be applicable to this product.
 NCBI GI #    32469599
 NCBI GeneID    80339
 NCBI Accession #    Q9NST1.2 [Other Products]
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 UniProt Primary Accession #    Q9NST1 [Other Products]
 UniProt Secondary Accession #    Q6P1A1; Q96CB4; B0QYI0; B2RCL3; B3KW00 [Other Products]
 UniProt Related Accession #    Q9NST1 [Other Products]
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 NCBI Official Full Name    Patatin-like phospholipase domain-containing protein 3
 NCBI Official Synonym Full Names    patatin like phospholipase domain containing 3
 NCBI Official Symbol    PNPLA3 [Similar Products]
 NCBI Official Synonym Symbols   
ADPN; C22orf20; iPLA(2)epsilon
[Similar Products]
 NCBI Protein Information    patatin-like phospholipase domain-containing protein 3
 UniProt Protein Name    Patatin-like phospholipase domain-containing protein 3
 UniProt Synonym Protein Names   
Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon
 Protein Family    Patatin-like phospholipase domain-containing protein
 UniProt Gene Name    PNPLA3 [Similar Products]
 UniProt Synonym Gene Names    ADPN; C22orf20; iPLA2-epsilon [Similar Products]
 UniProt Entry Name    PLPL3_HUMAN
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 NCBI Summary for PNPLA3    The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PNPLA3    PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Phospholipase; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 3.1.1.3; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - phenylalanine; Transferase; Amino Acid Metabolism - tyrosine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function: acylglycerol O-acyltransferase activity; diolein transacylation activity; lipoprotein lipase activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity

Biological Process: triacylglycerol biosynthetic process; triacylglycerol catabolic process
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 Research Articles on PNPLA3    1. PNPLA3 mRNA levels in the liver of the same section of a biopsy specimen used for genomic DNA preparation were lower in patients with advanced NAFLD compared with those with mild NAFLD and correlated inversely with CpG99 methylation in liver DNA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PNPLA3 antibodyPathways associated with anti-PNPLA3 antibody
 Reference Product  PubMed Publications
 PNPLA2 antibody  >10 publications with PNPLA3 and PNPLA2
 LPL antibody  >1 publications with PNPLA3 and LPL
 LPIN1 antibody  >1 publications with PNPLA3 and LPIN1
 DGAT2 antibody  >1 publications with PNPLA3 and DGAT2
 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of DAG And TAG Pathway antibodies  Acyl Chain Remodeling Of DAG And TAG Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with anti-PNPLA3 antibodyOrgans/Tissues associated with anti-PNPLA3 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >298 publications with PNPLA3 and Fatty Liver
 Liver Diseases Antibodies  >288 publications with PNPLA3 and Liver Diseases
 Non-alcoholic Fatty Liver Disease Antibodies  >185 publications with PNPLA3 and Non-alcoholic Fatty Liver Disease
 Fibrosis Antibodies  >117 publications with PNPLA3 and Fibrosis
 Liver Diseases, Alcoholic Antibodies  >72 publications with PNPLA3 and Liver Diseases, Alcoholic
 Liver Cirrhosis, Alcoholic Antibodies  >67 publications with PNPLA3 and Liver Cirrhosis, Alcoholic
 Carcinoma, Hepatocellular Antibodies  >62 publications with PNPLA3 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >42 publications with PNPLA3 and Inflammation
 Liver Neoplasms Antibodies  >32 publications with PNPLA3 and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >15 publications with PNPLA3 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >375 publications with PNPLA3 and Liver
 Blood Antibodies  >83 publications with PNPLA3 and Blood
 Muscle Antibodies  >3 publications with PNPLA3 and Muscle
 Kidney Antibodies  >3 publications with PNPLA3 and Kidney
 Pancreas Antibodies  >3 publications with PNPLA3 and Pancreas
 Brain Antibodies  >2 publications with PNPLA3 and Brain
 Eye Antibodies  >1 publications with PNPLA3 and Eye
 Embryonic Tissue Antibodies  >1 publications with PNPLA3 and Embryonic Tissue
 Intestine Antibodies  >1 publications with PNPLA3 and Intestine
 Skin Antibodies  >1 publications with PNPLA3 and Skin
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