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anti-PNPLA3 antibody :: Rabbit anti-Human, Mouse PNPLA3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6004839 anti-PNPLA3 antibody
Unit / Price
0.1 mg  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PNPLA3, Polyclonal Antibody

 Also Known As   

PNPLA3 (Patatin-like Phospholipase Domain-containing Protein 3, Acylglycerol O-acyltransferase, Adiponutrin, Calcium-independent Phospholipase A2-epsilon, iPLA2-epsilon, ADPN, C22orf20, dJ796I17.1, FLJ22012)

 Product Synonym Names    Anti -PNPLA3 (Patatin-like Phospholipase Domain-containing Protein 3, Acylglycerol O-acyltransferase, Adiponutrin, Calcium-independent Phospholipase A2-epsilon, iPLA2-epsilon, ADPN, C22orf20, dJ796I17.1, FLJ22012)
 Product Gene Name   

anti-PNPLA3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSGI PLEQTLQVLS DLVRKARSRN IGIFHPSFNL SKFLRQGLGK CLPANVHQLI SGKIGISLTR VSDGENVLVS DFRSKDEVVD ALVCSCFMPF YSGLIPPSFR GVRYVDGGVS DNVPFIDAKT TITVSPFYGE YDICPKVKST NFLHVDITKL SLRLCTGNLY LLSRAFVPPD LKVLGEICLR GYLDAFRFLE EKGICNRPQP GLKSSSEGMD PEVAMPSWAN MSLDSSPESA ALAVRLEGDE LLDHLRLSIL PWDESILDTL SPRLATALSE EMKDKGGYMS KICNLLPIRI MSYVMLPCTL PVESAIAIVQ RLVTWLPDMP DDVLWLQWVT SQVFTRVLMC LLPASRSQMP VSSQQASPCT PEQDWPCWTP CSPEGCPAET KAEATPRSIL RSSLNFFLGN KVPAGAEGLS TFPSFSLEKS L
 Chromosome Location    Chromosome: 22; NC_000022.10 (44319619..44343451). Location: 22q13.31
 OMIM    609567
 3D Structure    ModBase 3D Structure for Q9NST1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes human PNPLA3. Species Crossreactivity: mouse.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    Full length human PNPLA3, aa1-481 (AAH65195.1).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-PNPLA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PNPLA3 antibody

   Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.
 Product Categories/Family for anti-PNPLA3 antibody    Antibodies; Abs to Obesity Proteins
 Applications Tested/Suitable for anti-PNPLA3 antibody   

Western Blot (WB)

 Application Notes for anti-PNPLA3 antibody    Suitable for use in Western Blot.
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NCBI/Uniprot data below describe general gene information for PNPLA3. It may not necessarily be applicable to this product.
 NCBI GI #    17196626
 NCBI GeneID    80339
 NCBI Accession #    NP_079501.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_025225.2 [Other Products]
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 UniProt Primary Accession #    Q9NST1 [Other Products]
 UniProt Secondary Accession #    Q6P1A1; Q96CB4; B0QYI0; B2RCL3; B3KW00 [Other Products]
 UniProt Related Accession #    Q9NST1 [Other Products]
 Molecular Weight    52,865 Da [Similar Products]
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 NCBI Official Full Name    patatin-like phospholipase domain-containing protein 3
 NCBI Official Synonym Full Names    patatin-like phospholipase domain containing 3
 NCBI Official Symbol    PNPLA3 [Similar Products]
 NCBI Official Synonym Symbols   
ADPN; C22orf20; iPLA(2)epsilon
[Similar Products]
 NCBI Protein Information    patatin-like phospholipase domain-containing protein 3; adiponutrin; iPLA2epsilon; iPLA2-epsilon; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon
 UniProt Protein Name    Patatin-like phospholipase domain-containing protein 3
 UniProt Synonym Protein Names   
Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon
 Protein Family    Patatin-like phospholipase domain-containing protein
 UniProt Gene Name    PNPLA3 [Similar Products]
 UniProt Synonym Gene Names    ADPN; C22orf20; iPLA2-epsilon [Similar Products]
 UniProt Entry Name    PLPL3_HUMAN
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 NCBI Summary for PNPLA3    The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PNPLA3    PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Lipid Metabolism - glycerophospholipid; Phospholipase; Membrane protein, integral; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 3.1.1.3; Amino Acid Metabolism - tyrosine; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - phenylalanine

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: phospholipase A2 activity; triacylglycerol lipase activity; mono-olein transacylation activity; diolein transacylation activity

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; triacylglycerol catabolic process; triacylglycerol biosynthetic process
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 Research Articles on PNPLA3    1. In male PSC patients with severe disease with bile duct stenosis requiring intervention, the common I148M variant of the PNPLA3 gene is a risk factor for reduced survival.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PNPLA3 antibodyPathways associated with anti-PNPLA3 antibody
 Reference Product  PubMed Publications
 PNPLA2 antibody  >9 publications with PNPLA3 and PNPLA2
 DGAT2 antibody  >1 publications with PNPLA3 and DGAT2
 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of DAG And TAG Pathway antibodies  Acyl Chain Remodeling Of DAG And TAG Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with anti-PNPLA3 antibodyOrgans/Tissues associated with anti-PNPLA3 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >128 publications with PNPLA3 and Fatty Liver
 Liver Diseases Antibodies  >105 publications with PNPLA3 and Liver Diseases
 Non-alcoholic Fatty Liver Disease Antibodies  >59 publications with PNPLA3 and Non-alcoholic Fatty Liver Disease
 Insulin Resistance Antibodies  >47 publications with PNPLA3 and Insulin Resistance
 Fibrosis Antibodies  >46 publications with PNPLA3 and Fibrosis
 Liver Cirrhosis Antibodies  >41 publications with PNPLA3 and Liver Cirrhosis
 Inflammation Antibodies  >25 publications with PNPLA3 and Inflammation
 Liver Cirrhosis, Alcoholic Antibodies  >25 publications with PNPLA3 and Liver Cirrhosis, Alcoholic
 Liver Diseases, Alcoholic Antibodies  >19 publications with PNPLA3 and Liver Diseases, Alcoholic
 Carcinoma, Hepatocellular Antibodies  >18 publications with PNPLA3 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >166 publications with PNPLA3 and Liver
 Blood Antibodies  >42 publications with PNPLA3 and Blood
 Muscle Antibodies  >2 publications with PNPLA3 and Muscle
 Kidney Antibodies  >1 publications with PNPLA3 and Kidney
 Pancreas Antibodies  >1 publications with PNPLA3 and Pancreas
 Intestine Antibodies  >1 publications with PNPLA3 and Intestine
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