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anti-POT1 antibody :: Rabbit anti-Human POT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7053233
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

POT1, Polyclonal Antibody

★Popular Item★
 Also Known As   

POT1 Antibody

 Product Synonym Names    Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein; POT1
 Product Gene Name   

anti-POT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AY823520 mRNA
 3D Structure    ModBase 3D Structure for Q9NUX5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Protection of telomeres protein 1 protein (250-432AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-POT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-POT1 antibody

   Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.
 Applications Tested/Suitable for anti-POT1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-POT1 antibody    IHC: 1:20-1:200
IF: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-POT1 antibody    Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using MBS7053233 at dilution of 1:100
anti-POT1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-POT1 antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7053233 at dilution of 1:100
anti-POT1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-POT1 antibody    Immunofluorescent analysis of Hela cells using MBS7053233 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-POT1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for POT1. It may not necessarily be applicable to this product.
 NCBI GI #    110671314
 NCBI GeneID    25913
 NCBI Accession #    NP_001036059.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042594.1 [Other Products]
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 UniProt Primary Accession #    Q9NUX5 [Other Products]
 UniProt Secondary Accession #    O95018; Q5MJ36; Q9H662; Q9NW19; Q9UG95 [Other Products]
 UniProt Related Accession #    Q9NUX5 [Other Products]
 Molecular Weight    60,534 Da
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 NCBI Official Full Name    protection of telomeres protein 1 isoform 4
 NCBI Official Synonym Full Names    protection of telomeres 1
 NCBI Official Symbol    POT1 [Similar Products]
 NCBI Official Synonym Symbols   
GLM9; CMM10; HPOT1
[Similar Products]
 NCBI Protein Information    protection of telomeres protein 1
 UniProt Protein Name    Protection of telomeres protein 1
 UniProt Synonym Protein Names   
POT1-like telomere end-binding protein
 Protein Family    Potassium transporter
 UniProt Gene Name    POT1 [Similar Products]
 UniProt Synonym Gene Names    hPot1 [Similar Products]
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 NCBI Summary for POT1    This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for POT1    POT1: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'- TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Belongs to the telombin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7q31.33

Cellular Component: chromosome, telomeric region; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus

Molecular Function: DEAD/H-box RNA helicase binding; protein binding; single-stranded telomeric DNA binding; telomeric DNA binding

Biological Process: DNA duplex unwinding; negative regulation of telomerase activity; positive regulation of helicase activity; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; telomere assembly; telomere capping; telomere maintenance via telomerase

Disease: Glioma Susceptibility 9; Melanoma, Cutaneous Malignant, Susceptibility To, 10
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 Research Articles on POT1    1. Coats plus is caused by a defect in POT1/CST-dependent telomere fill-in
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-POT1 antibodyPathways associated with anti-POT1 antibody
 Reference Product  PubMed Publications
 TERT antibody  >55 publications with POT1 and TERT
 TERF2 antibody  >32 publications with POT1 and TERF2
 TINF2 antibody  >28 publications with POT1 and TINF2
 TERF2IP antibody  >17 publications with POT1 and TERF2IP
 ACD antibody  >14 publications with POT1 and ACD
 TERF1 antibody  >12 publications with POT1 and TERF1
 CTC1 antibody  >11 publications with POT1 and CTC1
 RAD50 antibody  >6 publications with POT1 and RAD50
 MRE11A antibody  >3 publications with POT1 and MRE11A
 H2AFX antibody  >2 publications with POT1 and H2AFX
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Damage/Telomere Stress Induced Senescence Pathway antibodies  DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
 Meiosis Pathway antibodies  Meiosis Pathway Diagram
 Meiotic Synapsis Pathway antibodies  Meiotic Synapsis Pathway Diagram
 Packaging Of Telomere Ends Pathway antibodies  Packaging Of Telomere Ends Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Shelterin Complex Pathway antibodies  Shelterin Complex Pathway Diagram
Diseases associated with anti-POT1 antibodyOrgans/Tissues associated with anti-POT1 antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >22 publications with POT1 and Chromosome Aberrations
 Melanoma Antibodies  >12 publications with POT1 and Melanoma
 Breast Neoplasms Antibodies  >10 publications with POT1 and Breast Neoplasms
 Leukemia, Lymphoid Antibodies  >8 publications with POT1 and Leukemia, Lymphoid
 Adenocarcinoma Antibodies  >7 publications with POT1 and Adenocarcinoma
 Anemia Antibodies  >6 publications with POT1 and Anemia
 Liver Neoplasms Antibodies  >5 publications with POT1 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with POT1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with POT1 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >3 publications with POT1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >27 publications with POT1 and Blood
 Bone Antibodies  >14 publications with POT1 and Bone
 Bone Marrow Antibodies  >10 publications with POT1 and Bone Marrow
 Brain Antibodies  >9 publications with POT1 and Brain
 Skin Antibodies  >6 publications with POT1 and Skin
 Lung Antibodies  >6 publications with POT1 and Lung
 Liver Antibodies  >6 publications with POT1 and Liver
 Kidney Antibodies  >5 publications with POT1 and Kidney
 Lymph Node Antibodies  >5 publications with POT1 and Lymph Node
 Stomach Antibodies  >5 publications with POT1 and Stomach
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