NP_006226.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,436 Da
NCBI Official Full Name
POU domain class 2-associating factor 1
NCBI Official Synonym Full Names
POU class 2 associating factor 1
NCBI Protein Information
POU domain class 2-associating factor 1; BOB-1; OCA-B; OCT-binding factor 1; B-cell-specific coactivator OBF-1; POU domain, class 2, associating factor 1
UniProt Protein Name
POU domain class 2-associating factor 1
UniProt Synonym Protein Names
B-cell-specific coactivator OBF-1; BOB-1; OCA-B; OCT-binding factor 1
UniProt Synonym Gene Names
UniProt Entry Name
OBF1_HUMAN
UniProt Comments for POU2AF1
POU2AF1: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6. Belongs to the POU2AF1 family.
Protein type: Transcription, coactivator/corepressor; Oncoprotein
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; transcription coactivator activity; transcription cofactor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; humoral immune response
Research Articles on POU2AF1
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Products associated with anti-POU2AF1 antibody
Diseases associated with anti-POU2AF1 antibody
Organs/Tissues associated with anti-POU2AF1 antibody
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