NP_006228.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
POU domain, class 4, transcription factor 1
NCBI Official Synonym Full Names
POU class 4 homeobox 1
NCBI Protein Information
POU domain, class 4, transcription factor 1
UniProt Protein Name
POU domain, class 4, transcription factor 1
UniProt Synonym Protein Names
Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A; Homeobox/POU domain protein RDC-1; Oct-T1
UniProt Synonym Gene Names
UniProt Entry Name
PO4F1_HUMAN
NCBI Summary for POU4F1
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012]
UniProt Comments for POU4F1
POU4F1: Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons. Belongs to the POU transcription factor family. Class- 4 subfamily.
Protein type: Cell development/differentiation; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 13q31.1
Cellular Component: neuron projection; nuclear chromatin
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding
Biological Process: transcription from RNA polymerase II promoter; trigeminal nerve development; central nervous system neuron differentiation; positive regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; habenula development; cell migration in hindbrain; peripheral nervous system neuron development; proprioception during equilibrioception; regulation of neurogenesis; synaptogenesis; axonogenesis; suckling behavior; neuron fate specification; mesoderm development; positive regulation of transcription from RNA polymerase II promoter; sensory system development; negative regulation of neuron apoptosis
Product References and Citations for anti-POU4F1 antibody
Bhargava A.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:10260-10264(1993). Xiang M.,et al.J. Neurosci. 15:4762-4785(1995). Dunham A.,et al.Nature 428:522-528(2004). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Collum R.G.,et al.Nucleic Acids Res. 20:4919-4925(1992).
Research Articles on POU4F1
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Products associated with anti-POU4F1 antibody
Pathways associated with anti-POU4F1 antibody
Diseases associated with anti-POU4F1 antibody
Organs/Tissues associated with anti-POU4F1 antibody
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