NP_002691.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,052 Da
NCBI Official Full Name
POU domain, class 4, transcription factor 3
NCBI Official Synonym Full Names
POU class 4 homeobox 3
NCBI Protein Information
POU domain, class 4, transcription factor 3
UniProt Protein Name
POU domain, class 4, transcription factor 3
UniProt Synonym Protein Names
Brain-specific homeobox/POU domain protein 3C; Brain-3C; Brn-3C
UniProt Synonym Gene Names
UniProt Entry Name
PO4F3_HUMAN
NCBI Summary for POU4F3
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]
UniProt Comments for POU4F3
POU4F3: May play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in POU4F3 are the cause of deafness autosomal dominant type 15 (DFNA15). DFNA15 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the POU transcription factor family. Class- 4 subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: nucleoplasm
Molecular Function: transcription factor activity
Biological Process: vestibulocochlear nerve development; inner ear morphogenesis; neuron apoptosis; sensory perception of sound; visual perception; axon extension; auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; neuromuscular process controlling balance; retinal ganglion cell axon guidance
Disease: Deafness, Autosomal Dominant 15
Research Articles on POU4F3
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Products associated with anti-POU4F3 antibody
Diseases associated with anti-POU4F3 antibody
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