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anti-POU6F2 antibody :: Rabbit anti-Human, Mouse POU6F2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9402684
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

POU6F2, Polyclonal Antibody

★Popular Item★
 Also Known As   

POU6F2 Antibody

 Product Synonym Names    WT5; WTSL; RPF-1
 Product Gene Name   

anti-POU6F2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601583
 3D Structure    ModBase 3D Structure for P78424
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    The antibody detects endogenous levels of total POU6F2 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    1.9 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthetic peptide corresponding to a region derived from internal residues of human POU class 6 homeobox 2
 SDS-PAGE MW    73 kD
 Target Name    POU6F2
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 Preparation and Storage    Store at -20C
 Other Notes    Small volumes of anti-POU6F2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-POU6F2 antibody

   This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition.
 Product Categories/Family for anti-POU6F2 antibody    Total protein Ab
 Applications Tested/Suitable for anti-POU6F2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-POU6F2 antibody    Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200
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 Testing Data of anti-POU6F2 antibody    Gel: 6%SDS-PAGE Lysates (from left to right): Mouse heart tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/200 dilution
Secondary antibody dilution: 1/8000
Exposure time: 30 seconds
anti-POU6F2 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-POU6F2 antibody    Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.
anti-POU6F2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for POU6F2. It may not necessarily be applicable to this product.
 NCBI GI #    260436858
 NCBI GeneID    11281
 NCBI Accession #    NP_001159490/P78424 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166018.1 [Other Products]
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 UniProt Primary Accession #    P78424 [Other Products]
 UniProt Secondary Accession #    P78425; Q75ME8; Q86UM6; Q9UDS7; A4D1W2; C4AMB9 [Other Products]
 UniProt Related Accession #    P78424 [Other Products]
 Molecular Weight    N/A
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 NCBI Official Full Name    POU domain, class 6, transcription factor 2 isoform 2
 NCBI Official Synonym Full Names    POU class 6 homeobox 2
 NCBI Official Symbol    POU6F2 [Similar Products]
 NCBI Official Synonym Symbols   
WT5; WTSL; RPF-1
[Similar Products]
 NCBI Protein Information    POU domain, class 6, transcription factor 2
 UniProt Protein Name    POU domain, class 6, transcription factor 2
 UniProt Synonym Protein Names   
Retina-derived POU domain factor 1; RPF-1
 Protein Family    POU domain, class 6, transcription factor
 UniProt Gene Name    POU6F2 [Similar Products]
 UniProt Synonym Gene Names    RPF1; RPF-1 [Similar Products]
 UniProt Entry Name    PO6F2_HUMAN
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 NCBI Summary for POU6F2    This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
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 UniProt Comments for POU6F2    POU6F2: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. Defects in POU6F2 are a cause of hereditary susceptibility to Wilms tumor 5 (WT5). WT5 is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. Belongs to the POU transcription factor family. Class- 6 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Cell development/differentiation; DNA-binding

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-dependent; visual perception; ganglion mother cell fate determination

Disease: Wilms Tumor 5
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 Research Articles on POU6F2    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-POU6F2 antibodyDiseases associated with anti-POU6F2 antibody
 Reference Product  PubMed Publications
 WT1 antibody  >2 publications with POU6F2 and WT1
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3 publications with POU6F2 and Kidney Diseases
 Autistic Disorder Antibodies  >1 publications with POU6F2 and Autistic Disorder
Organs/Tissues associated with anti-POU6F2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with POU6F2 and Brain
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