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anti-PP2A antibody :: Rabbit PP2A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS551072
Immunohistochemistry
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PP2A, Polyclonal Antibody

 Also Known As   

Rabbit anti PP2A Polyclonal

 Product Synonym Names    Rabbit anti PP2A Polyclonal purified; PP2A; PPP2CA polyclonal
 Product Gene Name   

anti-PP2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176915
 3D Structure    ModBase 3D Structure for P67775
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Serum IgG fraction was purified by Protein G affinity chromatography.
 Form/Format    Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
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 Source Note    Polyclonal Protein Phosphatase 2A-PP2A antibody was produced from sera of mice immunized with synthetic protein containingPP2A antigenic determinants.
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
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 Preparation and Storage    The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
 Other Notes    Small volumes of anti-PP2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PP2A antibody    Polyclonal
 Applications Tested/Suitable for anti-PP2A antibody   

Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)

 Application Notes for anti-PP2A antibody    ELISA: Use at a concentration range of 1-2ug/ml.
Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Immunohistochemical analysis of PPFE rat hippocampus tissue expressing PP2A.
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 Immunohistochemistry of anti-PP2A antibody    anti-PP2A antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for PP2A. It may not necessarily be applicable to this product.
 NCBI GI #    4506017
 NCBI GeneID    5515
 NCBI Accession #    NP_002706.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002715.2 [Other Products]
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 UniProt Primary Accession #    P67775 [Other Products]
 UniProt Secondary Accession #    P05323; P13197 [Other Products]
 UniProt Related Accession #    P67775; Q6I9T8 [Other Products]
 Molecular Weight    35,594 Da
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 NCBI Official Full Name    serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
 UniProt Protein Name    Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
 UniProt Synonym Protein Names   
Replication protein C
 Protein Family    PP2A regulatory
 UniProt Gene Name    PPP2CA [Similar Products]
 UniProt Synonym Gene Names    PP2A-alpha; RP-C [Similar Products]
 UniProt Entry Name    PP2AA_HUMAN
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 NCBI Summary for PP2A    This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PP2A    PPP2CA: ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; membrane; mitochondrion; plasma membrane; nucleus; cytosol; chromosome, pericentric region

Molecular Function: protein C-terminus binding; protein dimerization activity; protein binding; metal ion binding; GABA receptor binding; protein serine/threonine phosphatase activity

Biological Process: mitotic nuclear envelope reassembly; apoptosis; regulation of protein amino acid autophosphorylation; protein amino acid dephosphorylation; response to organic substance; regulation of transcription, DNA-dependent; meiotic cell cycle; regulation of growth; regulation of cell differentiation; mesoderm development; regulation of receptor activity; regulation of DNA replication; inactivation of MAPK activity; regulation of cell adhesion; second-messenger-mediated signaling; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat3 protein; mRNA catabolic process, nonsense-mediated decay; regulation of protein catabolic process; gene expression; mitotic cell cycle; negative regulation of cell growth; ceramide metabolic process
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Product References and Citations for anti-PP2A antibody

   β1-integrin-collagen interaction suppresses foxo3a by the coordination of akt and PP2A .J. Biol. Chem., May 2010; 285: 14195 - 14209.
the b563 regulatory subunit of PP2A regulates s phase-specific nuclear accumulation of PP2A and the g1 to s transition .J. Biol. Chem., May 2010; 10.1074/jbc.M109.094953.
protein phosphatase 2a (PP2A) holoenzymes regulate death-associated protein kinase (dapk) in ceramide-induced anoikis .J. Biol. Chem., Apr 2010; 285: 13827 - 13838.
neuroprotectin d1 induces dephosphorylation of bcl-xl in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival .J. Biol. Chem., Apr 2010; 10.1074/jbc.M109.095232.
pr65, the heat-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis .PNAS, Feb 2010; 107: 2467 - 2472.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PP2A antibodyPathways associated with anti-PP2A antibody
 Reference Product  PubMed Publications
 SET antibody  >60 publications with PP2A and SET
 PPP2R1B antibody  >58 publications with PP2A and PPP2R1B
 MAPK1 antibody  >57 publications with PP2A and MAPK1
 MAPK3 antibody  >44 publications with PP2A and MAPK3
 AKT1 antibody  >26 publications with PP2A and AKT1
 PPP2R2A antibody  >21 publications with PP2A and PPP2R2A
 APC antibody  >19 publications with PP2A and APC
 RHO antibody  >19 publications with PP2A and RHO
 JAK2 antibody  >18 publications with PP2A and JAK2
 PPP2R1A antibody  >18 publications with PP2A and PPP2R1A
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
Diseases associated with anti-PP2A antibodyOrgans/Tissues associated with anti-PP2A antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >323 publications with PP2A and Neoplasms
 Neurodegenerative Diseases Antibodies  >86 publications with PP2A and Neurodegenerative Diseases
 Leukemia Antibodies  >69 publications with PP2A and Leukemia
 Dementia Antibodies  >61 publications with PP2A and Dementia
 Mental Disorders Antibodies  >57 publications with PP2A and Mental Disorders
 Necrosis Antibodies  >55 publications with PP2A and Necrosis
 Cell Transformation, Neoplastic Antibodies  >51 publications with PP2A and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >46 publications with PP2A and Heart Diseases
 Inflammation Antibodies  >34 publications with PP2A and Inflammation
 Leukemia, Myeloid Antibodies  >30 publications with PP2A and Leukemia, Myeloid
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >318 publications with PP2A and Brain
 Muscle Antibodies  >236 publications with PP2A and Muscle
 Blood Antibodies  >208 publications with PP2A and Blood
 Heart Antibodies  >127 publications with PP2A and Heart
 Liver Antibodies  >127 publications with PP2A and Liver
 Nerve Antibodies  >94 publications with PP2A and Nerve
 Kidney Antibodies  >85 publications with PP2A and Kidney
 Lung Antibodies  >75 publications with PP2A and Lung
 Vascular Antibodies  >74 publications with PP2A and Vascular
 Eye Antibodies  >38 publications with PP2A and Eye
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