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anti-PPARD antibody :: Rabbit anti-Human PPARd Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS612577 anti-PPARD antibody
Unit / Price
0.1 mg  /  $740 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPARd, Polyclonal Antibody

 Also Known As   

PPARd (Peroxisome Proliferator Activated Receptor, delta)

 Product Synonym Names    Anti -PPARd (Peroxisome Proliferator Activated Receptor, delta)
 Product Gene Name   

anti-PPARD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (35310335..35395968). Location: 6p21.2
 OMIM    600409
 3D Structure    ModBase 3D Structure for Q03181
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes the human PPAR delta. Expected to react with mouse and rat based on 100% sequence homology. Crossreactivity with PPAR delta from human, chimpanzee and rabbit may occur as this sequence shows 85% homology with the protein from these sources. No reactivity is expected with other subtypesof PPAR.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide. No stabilizing proteins added.
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 Immunogen    A synthetic peptide, MEQPQEETPEAREE, corresponding to an internal region of mouse PPAR delta.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-PPARD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPARD antibody

   Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and antidiabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPARgamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.
 Product Categories/Family for anti-PPARD antibody    Antibodies; Abs to Obesity Proteins
 Applications Tested/Suitable for anti-PPARD antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-PPARD antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:2000-1:8000
Western Blot: 1:500-1:2000.
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NCBI/Uniprot data below describe general gene information for PPARD. It may not necessarily be applicable to this product.
 NCBI GI #    284807159
 NCBI GeneID    5467
 NCBI Accession #    NP_001165291.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001171820.1 [Other Products]
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 UniProt Primary Accession #    Q03181 [Other Products]
 UniProt Secondary Accession #    Q5D1P0; Q7Z5K0; Q9BUD4; A8K6J6; B6ZGS1 [Other Products]
 UniProt Related Accession #    Q03181 [Other Products]
 Molecular Weight    49,903 Da [Similar Products]
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 NCBI Official Full Name    peroxisome proliferator-activated receptor delta isoform 4
 NCBI Official Synonym Full Names    peroxisome proliferator-activated receptor delta
 NCBI Official Symbol    PPARD [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; OTTHUMP00000016256; OTTHUMP00000016257; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2
 UniProt Protein Name    Peroxisome proliferator-activated receptor delta
 UniProt Synonym Protein Names   
NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta
 Protein Family    Peroxisome proliferator-activated receptor
 UniProt Gene Name    PPARD [Similar Products]
 UniProt Synonym Gene Names    NR1C2; PPARB [Similar Products]
 UniProt Entry Name    PPARD_HUMAN
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 NCBI Summary for PPARD    This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq]
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 UniProt Comments for PPARD    PPAR-delta: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Belongs to the nuclear hormone receptor family. NR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6p21.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: NF-kappaB binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; drug binding; transcription factor activity; lipid binding

Biological Process: proteoglycan metabolic process; wound healing; negative regulation of smooth muscle cell proliferation; heart development; negative regulation of collagen biosynthetic process; positive regulation of transcription, DNA-dependent; positive regulation of epidermis development; negative regulation of smooth muscle cell migration; glucose transport; negative regulation of transcription from RNA polymerase II promoter; decidualization; positive regulation of vasodilation; vitamin A metabolic process; response to vitamin A; positive regulation of cell proliferation; response to glucose stimulus; axon ensheathment; cell differentiation; negative regulation of epithelial cell proliferation; transcription initiation from RNA polymerase II promoter; cholesterol metabolic process; generation of precursor metabolites and energy; intracellular receptor-mediated signaling pathway; glucose metabolic process; positive regulation of insulin secretion; fatty acid catabolic process; keratinocyte proliferation; keratinocyte migration; cell-substrate adhesion; phospholipid biosynthetic process; regulation of transcription from RNA polymerase II promoter; positive regulation of phosphoinositide 3-kinase cascade; cell proliferation; fatty acid beta-oxidation; negative regulation of inflammatory response; mRNA transcription; positive regulation of fat cell differentiation; steroid hormone mediated signaling; gene expression; response to activity; negative regulation of cell growth; lipid metabolic process; negative regulation of transcription, DNA-dependent; embryo implantation; fatty acid transport; negative regulation of apoptosis
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 Research Articles on PPARD    1. the association of PPARD +294T > C polymorphism and serum lipid levels is different between the Bai Ku Yao and Han populations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPARD antibodyPathways associated with anti-PPARD antibody
 Reference Product  PubMed Publications
 RXRA antibody  >4 publications with PPARD and RXRA
 RXRB antibody  >2 publications with PPARD and RXRB
 RXRG antibody  >1 publications with PPARD and RXRG
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-PPARD antibodyOrgans/Tissues associated with anti-PPARD antibody
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >17 publications with PPARD and Metabolic Diseases
 Insulin Resistance Antibodies  >10 publications with PPARD and Insulin Resistance
 Obesity Antibodies  >10 publications with PPARD and Obesity
 Neoplasms Antibodies  >9 publications with PPARD and Neoplasms
 Cardiovascular Diseases Antibodies  >8 publications with PPARD and Cardiovascular Diseases
 Diabetes Mellitus, Type 2 Antibodies  >7 publications with PPARD and Diabetes Mellitus, Type 2
 Diabetes Mellitus Antibodies  >7 publications with PPARD and Diabetes Mellitus
 Heart Diseases Antibodies  >5 publications with PPARD and Heart Diseases
 Myocardial Ischemia Antibodies  >5 publications with PPARD and Myocardial Ischemia
 Atherosclerosis Antibodies  >5 publications with PPARD and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with PPARD and Blood
 Muscle Antibodies  >14 publications with PPARD and Muscle
 Connective Tissue Antibodies  >7 publications with PPARD and Connective Tissue
 Placenta Antibodies  >5 publications with PPARD and Placenta
 Vascular Antibodies  >4 publications with PPARD and Vascular
 Uterus Antibodies  >3 publications with PPARD and Uterus
 Intestine Antibodies  >3 publications with PPARD and Intestine
 Skin Antibodies  >2 publications with PPARD and Skin
 Embryonic Tissue Antibodies  >2 publications with PPARD and Embryonic Tissue
 Kidney Antibodies  >2 publications with PPARD and Kidney
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