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anti-PPARG antibody :: Rabbit anti-Human PPARg1,2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS619780 anti-PPARG antibody
Unit / Price
0.1 mg  /  $740 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPARg1,2, Polyclonal Antibody

 Also Known As   

PPARg1,2 (Peroxisome Proliferator Activated Receptor, gamma)

 Product Synonym Names    Anti -PPARg1,2 (Peroxisome Proliferator Activated Receptor, gamma)
 Product Gene Name   

anti-PPARG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (12329349..12475855). Location: 3p25
 OMIM    137800
 3D Structure    ModBase 3D Structure for P37231
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human PPARg1,2. No reactivity expected against other subtypes of PPAR. Species Sequence Homology: mouse (g1 and g2), rat, squirrel, orangutan, duck (g1), macaque (g1-g7), boar (g1a-1d), mink, guinea pig, rabbit (g1 and g3), canine and hamster
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide. No stabilizing proteins added.
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 Immunogen    Synthetic peptide corresponding to aa255-268 from human PPAR gamma isoform 1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-PPARG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPARG antibody

   Since their discovery in the early 1990's, the peroxisome proliferator activated receptors (PPARs) have attracted significant attention. This is primarily because PPARs serve as receptors for two very important classes of drugs: the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones. Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs. Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Upon binding fatty acids or hypolipidemic drugs, PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes. There are 3 known subtypes of PPARs: PPAR-alpha, PPAR-delta and PPAR-gamma. Mostly target genes are involved in the catabolism of fatty acids. Conversely, PPAR-gamma is activated by peroxisome proliferators such as prostaglandins, leukotrienes and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPAR-gamma may also be involved in adipocyte differentiation. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.
 Product Categories/Family for anti-PPARG antibody    Antibodies; Abs to Obesity Proteins
 Applications Tested/Suitable for anti-PPARG antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-PPARG antibody    Suitable for use in ELISA.
Dilution: ELISA: 1:8000-1:32,000
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NCBI/Uniprot data below describe general gene information for PPARG. It may not necessarily be applicable to this product.
 NCBI GI #    20336229
 NCBI GeneID    5468
 NCBI Accession #    NP_056953.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015869.4 [Other Products]
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 UniProt Primary Accession #    P37231 [Other Products]
 UniProt Secondary Accession #    O00684; O00710; O14515; Q15178; Q15179; Q15180; Q15832; Q86U60; Q96J12; A8K3G6; B5BUA1 [Other Products]
 UniProt Related Accession #    P37231; Q0QJH8; Q4W448; Q4W4C6; Q4W4C7; Q53EW1; Q6L9M1; Q86WD1; Q9UEF6 [Other Products]
 Molecular Weight    57,620 Da [Similar Products]
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 NCBI Official Full Name    peroxisome proliferator-activated receptor gamma isoform 2
 NCBI Official Synonym Full Names    peroxisome proliferator-activated receptor gamma
 NCBI Official Symbol    PPARG [Similar Products]
 NCBI Official Synonym Symbols   
GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
[Similar Products]
 NCBI Protein Information    peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; OTTHUMP00000160185; OTTHUMP00000160186; OTTHUMP00000185030; OTTHUMP00000185032; OTTHUMP00000185034; OTTHUMP00000185036; OTTHUMP00000207750; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1
 UniProt Protein Name    Peroxisome proliferator-activated receptor gamma
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group C member 3
 Protein Family    Peroxisome proliferator-activated receptor
 UniProt Gene Name    PPARG [Similar Products]
 UniProt Synonym Gene Names    NR1C3 [Similar Products]
 UniProt Entry Name    PPARG_HUMAN
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 NCBI Summary for PPARG    This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq]
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 UniProt Comments for PPARG    PPAR-gamma: a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytosol; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; alpha-actinin binding; protein phosphatase binding; arachidonic acid binding; retinoid X receptor binding; protein binding; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; estrogen receptor binding; chromatin binding; transcription factor activity

Biological Process: negative regulation of collagen biosynthetic process; positive regulation of transcription, DNA-dependent; heart development; cell maturation; rhythmic process; lipid homeostasis; glucose homeostasis; response to lipid; response to vitamin A; response to caffeine; positive regulation of oligodendrocyte differentiation; placenta development; long-chain fatty acid transport; organ regeneration; cell fate commitment; monocyte differentiation; negative regulation of acute inflammatory response; regulation of circadian rhythm; response to starvation; negative regulation of telomerase activity; cellular response to insulin stimulus; response to estrogen stimulus; response to mechanical stimulus; lipoprotein transport; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; fatty acid oxidation; negative regulation of transcription, DNA-dependent; positive regulation of phagocytosis, engulfment; negative regulation of smooth muscle cell proliferation; low-density lipoprotein receptor biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; epithelial cell differentiation; regulation of blood pressure; response to nutrient; caspase activation; transcription initiation from RNA polymerase II promoter; response to retinoic acid; G-protein coupled receptor protein signaling pathway; response to low density lipoprotein stimulus; white fat cell differentiation; positive regulation of fatty acid oxidation; innate immune response; gene expression; response to cold; negative regulation of cell growth; lipid metabolic process

Disease: Obesity; Carotid Intimal Medial Thickness 1; Lipodystrophy, Familial Partial, Type 3; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on PPARG    1. The results of this study suggested that PPAR-gamma genetic variants may modify the risk of alzheimer disease in an APOE epsilon4 allele-dependent fashion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPARG antibodyPathways associated with anti-PPARG antibody
 Reference Product  PubMed Publications
 PPARGC1A antibody  >193 publications with PPARG and PPARGC1A
 MAPK1 antibody  >57 publications with PPARG and MAPK1
 FOXO1 antibody  >30 publications with PPARG and FOXO1
 NCOA1 antibody  >26 publications with PPARG and NCOA1
 NCOR2 antibody  >21 publications with PPARG and NCOR2
 MED1 antibody  >18 publications with PPARG and MED1
 NCOR1 antibody  >18 publications with PPARG and NCOR1
 NFE2L2 antibody  >15 publications with PPARG and NFE2L2
 FABP1 antibody  >10 publications with PPARG and FABP1
 HDAC3 antibody  >9 publications with PPARG and HDAC3
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Noncanonical Wnt Signaling Pathway antibodies  Noncanonical Wnt Signaling Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
Diseases associated with anti-PPARG antibodyOrgans/Tissues associated with anti-PPARG antibody
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >1888 publications with PPARG and Metabolic Diseases
 Insulin Resistance Antibodies  >1228 publications with PPARG and Insulin Resistance
 Diabetes Mellitus Antibodies  >1217 publications with PPARG and Diabetes Mellitus
 Inflammation Antibodies  >1196 publications with PPARG and Inflammation
 Obesity Antibodies  >1121 publications with PPARG and Obesity
 Cardiovascular Diseases Antibodies  >1056 publications with PPARG and Cardiovascular Diseases
 Neoplasms Antibodies  >1047 publications with PPARG and Neoplasms
 Diabetes Mellitus, Type 2 Antibodies  >848 publications with PPARG and Diabetes Mellitus, Type 2
 Atherosclerosis Antibodies  >554 publications with PPARG and Atherosclerosis
 Fatty Liver Antibodies  >500 publications with PPARG and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >1169 publications with PPARG and Adipose Tissue
 Liver Antibodies  >1159 publications with PPARG and Liver
 Connective Tissue Antibodies  >859 publications with PPARG and Connective Tissue
 Vascular Antibodies  >859 publications with PPARG and Vascular
 Heart Antibodies  >491 publications with PPARG and Heart
 Brain Antibodies  >384 publications with PPARG and Brain
 Bone Antibodies  >381 publications with PPARG and Bone
 Kidney Antibodies  >380 publications with PPARG and Kidney
 Lung Antibodies  >298 publications with PPARG and Lung
 Intestine Antibodies  >175 publications with PPARG and Intestine
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