Q13136.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Liprin-alpha-1
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
NCBI Protein Information
liprin-alpha-1; LIP-1; Liprin-alpha1; LAR-interacting protein 1; PTPRF-interacting protein alpha-1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
UniProt Protein Name
Liprin-alpha-1
UniProt Synonym Protein Names
LAR-interacting protein 1; LIP-1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PTPRF-interacting protein alpha-1
UniProt Synonym Gene Names
UniProt Entry Name
LIPA1_HUMAN
NCBI Summary for PPFIA1
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for PPFIA1
liprin alpha 1: a ubiqutous member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Two alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 11q13.3
Cellular Component: focal adhesion; cytoplasm; presynaptic active zone; cytosol
Molecular Function: signal transducer activity; protein binding
Biological Process: synaptic transmission; negative regulation of stress fiber formation; glutamate secretion; cell-matrix adhesion; neurotransmitter secretion; signal transduction
Research Articles on PPFIA1
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Products associated with anti-PPFIA1 antibody
Pathways associated with anti-PPFIA1 antibody
Diseases associated with anti-PPFIA1 antibody
Organs/Tissues associated with anti-PPFIA1 antibody
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