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anti-PPP1R12A antibody :: Rabbit PPP1R12A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2529823
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPP1R12A, Polyclonal Antibody

★Popular Item★
 Also Known As   

PPP1R12A Polyclonal Antibody

 Product Synonym Names    MBS; M130; MYPT1
 Product Gene Name   

anti-PPP1R12A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602021
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.3mg/mL (lot specific)
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 Immunogen    Recombinant protein of human PPP1R12A
 Calculated Molecular Weight: 115kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PPP1R12A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPP1R12A antibody

   Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP. RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC.
 Applications Tested/Suitable for anti-PPP1R12A antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PPP1R12A antibody    WB: 1:1000-1:5000
IHC: 1:25-1:100
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 Western Blot (WB) of anti-PPP1R12A antibody    Western Blot analysis of NIH/3T3, A172, hela and PC3 cell using PPP1R12A Polyclonal Antibody at dilution of 1:350
anti-PPP1R12A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PPP1R12A antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer using PPP1R12A Polyclonal Antibody at dilution of 1:25
anti-PPP1R12A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PPP1R12A. It may not necessarily be applicable to this product.
 NCBI GI #    84627432
 NCBI GeneID    4659
 NCBI Accession #    AAI11753.1 [Other Products]
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 UniProt Secondary Accession #    Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0; B4DZ09; F8VWB4 [Other Products]
 UniProt Related Accession #    O14974 [Other Products]
 Molecular Weight    105,641 Da
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 NCBI Official Full Name    PPP1R12A protein
 NCBI Official Synonym Full Names    protein phosphatase 1, regulatory subunit 12A
 NCBI Official Symbol    PPP1R12A [Similar Products]
 NCBI Official Synonym Symbols   
MBS; M130; MYPT1
[Similar Products]
 NCBI Protein Information    protein phosphatase 1 regulatory subunit 12A; myosin binding subunit; myosin phosphatase, target subunit 1; myosin phosphatase-targeting subunit 1; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase myosin-binding subunit
 UniProt Protein Name    Protein phosphatase 1 regulatory subunit 12A
 UniProt Synonym Protein Names   
Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit
 Protein Family    Protein phosphatase 1 regulatory
 UniProt Gene Name    PPP1R12A [Similar Products]
 UniProt Synonym Gene Names    MBS; MYPT1; Myosin phosphatase target subunit 1 [Similar Products]
 UniProt Entry Name    MYPT1_HUMAN
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 NCBI Summary for PPP1R12A    Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for PPP1R12A    MYPT1: myosin phosphatase target subunit 1, a regulatory subunit of protein phosphatase 1. Also called the myosin-binding subunit of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. Four splice-variant isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 12q15-q21

Cellular Component: nucleoplasm; kinetochore; centrosome; focal adhesion; contractile fiber; cytoplasm; actin cytoskeleton

Molecular Function: enzyme inhibitor activity; protein binding; signal transducer activity; phosphatase regulator activity; protein kinase binding

Biological Process: regulation of cell adhesion; mitosis; centrosome organization and biogenesis; regulation of nucleocytoplasmic transport; negative regulation of catalytic activity; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; G2/M transition of mitotic cell cycle; signal transduction; protein amino acid dephosphorylation
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 Research Articles on PPP1R12A    1. Expression of NUAK1 is controlled by cyclin-dependent kinase, PLK1, and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPP1R12A antibodyPathways associated with anti-PPP1R12A antibody
 Reference Product  PubMed Publications
 PPP1R14A antibody  >30 publications with PPP1R12A and PPP1R14A
 ROCK2 antibody  >12 publications with PPP1R12A and ROCK2
 PLK1 antibody  >4 publications with PPP1R12A and PLK1
 ILK antibody  >2 publications with PPP1R12A and ILK
 DMPK antibody  >1 publications with PPP1R12A and DMPK
 PPP1CB antibody  >1 publications with PPP1R12A and PPP1CB
 PRKG1 antibody  >1 publications with PPP1R12A and PRKG1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 PLK1 Signaling Events Pathway antibodies  PLK1 Signaling Events Pathway Diagram
Diseases associated with anti-PPP1R12A antibodyOrgans/Tissues associated with anti-PPP1R12A antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >24 publications with PPP1R12A and Hypertension
 Disease Models, Animal Antibodies  >18 publications with PPP1R12A and Disease Models, Animal
 Heart Diseases Antibodies  >7 publications with PPP1R12A and Heart Diseases
 Necrosis Antibodies  >6 publications with PPP1R12A and Necrosis
 Fibrosis Antibodies  >5 publications with PPP1R12A and Fibrosis
 Nervous System Diseases Antibodies  >5 publications with PPP1R12A and Nervous System Diseases
 Kidney Diseases Antibodies  >5 publications with PPP1R12A and Kidney Diseases
 Heart Failure Antibodies  >4 publications with PPP1R12A and Heart Failure
 Inflammation Antibodies  >4 publications with PPP1R12A and Inflammation
 Myocardial Infarction Antibodies  >3 publications with PPP1R12A and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >108 publications with PPP1R12A and Muscle
 Vascular Antibodies  >91 publications with PPP1R12A and Vascular
 Blood Antibodies  >32 publications with PPP1R12A and Blood
 Lung Antibodies  >19 publications with PPP1R12A and Lung
 Heart Antibodies  >12 publications with PPP1R12A and Heart
 Liver Antibodies  >10 publications with PPP1R12A and Liver
 Intestine Antibodies  >9 publications with PPP1R12A and Intestine
 Uterus Antibodies  >8 publications with PPP1R12A and Uterus
 Kidney Antibodies  >7 publications with PPP1R12A and Kidney
 Eye Antibodies  >4 publications with PPP1R12A and Eye
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