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anti-PPP1R14A antibody :: Rabbit anti-Human PPP1R14A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004210
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPP1R14A, Polyclonal Antibody

★Popular Item★
 Also Known As   

PPP1R14A Antibody

 Product Synonym Names    Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17; PPP1R14A; CPI17; PPP1INL
 Product Gene Name   

anti-PPP1R14A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608153
 3D Structure    ModBase 3D Structure for Q96A00
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Protein phosphatase 1 regulatory subunit 14A protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17561 / sc-30927 / sc-30930 / sc-48406 / sc-25751
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PPP1R14A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPP1R14A antibody

   Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
 Applications Tested/Suitable for anti-PPP1R14A antibody   

ELISA (EIA), Immunohistochemistry (IHC)

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 Immunohistochemistry (IHC) of anti-PPP1R14A antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7004210 at dilution of 1:100
anti-PPP1R14A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PPP1R14A antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7004210 at dilution of 1:100
anti-PPP1R14A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PPP1R14A. It may not necessarily be applicable to this product.
 NCBI GI #    345441807
 NCBI GeneID    94274
 NCBI Accession #    NP_001230876.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001243947.1 [Other Products]
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 UniProt Primary Accession #    Q96A00 [Other Products]
 UniProt Secondary Accession #    Q7Z4X7; Q96S54 [Other Products]
 UniProt Related Accession #    Q96A00 [Other Products]
 Molecular Weight    13,480 Da
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 NCBI Official Full Name    protein phosphatase 1 regulatory subunit 14A isoform 2
 NCBI Official Synonym Full Names    protein phosphatase 1 regulatory inhibitor subunit 14A
 NCBI Official Symbol    PPP1R14A [Similar Products]
 NCBI Official Synonym Symbols   
CPI17; CPI-17; PPP1INL
[Similar Products]
 NCBI Protein Information    protein phosphatase 1 regulatory subunit 14A
 UniProt Protein Name    Protein phosphatase 1 regulatory subunit 14A
 UniProt Synonym Protein Names   
17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17
 UniProt Gene Name    PPP1R14A [Similar Products]
 UniProt Synonym Gene Names    CPI17; PPP1INL; CPI-17 [Similar Products]
 UniProt Entry Name    PP14A_HUMAN
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 NCBI Summary for PPP1R14A    The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for PPP1R14A    PPP1R14A: a phosphorylation-dependent inhibitory subunit of protein phosphatase 1 (PP-1A). Phosphorylation by PKC regulates its binding to PP-1A. Acts co-operatively to inhibit myosin light chain phosphatase (MLCP) activity. Inhibition leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2 ) concentration. Involved in the regulation of cell morphology, re-organisation of microfilaments, and cell spreading. Also expressed in human platelets and in brain where it may play a role in cerebellar long-term synaptic depression. Phosphorylation by ILK or Rho kinase enhances its ability to inhibit PP-1A.

Protein type: Inhibitor; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cytosol

Molecular Function: protein phosphatase inhibitor activity

Biological Process: negative regulation of catalytic activity; regulation of phosphorylation; small GTPase mediated signal transduction
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 Research Articles on PPP1R14A    1. CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPP1R14A antibodyPathways associated with anti-PPP1R14A antibody
 Reference Product  PubMed Publications
 PPP1R12A antibody  >33 publications with PPP1R14A and PPP1R12A
 ILK antibody  >3 publications with PPP1R14A and ILK
 ROCK1 antibody  >2 publications with PPP1R14A and ROCK1
 PPP1CB antibody  >1 publications with PPP1R14A and PPP1CB
 PRKCB antibody  >1 publications with PPP1R14A and PRKCB
 PKN1 antibody  >1 publications with PPP1R14A and PKN1
 PPP1R12B antibody  >1 publications with PPP1R14A and PPP1R12B
 Products by Pathway  Pathway Diagram
 RHO GTPase Effectors Pathway antibodies  RHO GTPase Effectors Pathway Diagram
 RHO GTPases Activate PKNs Pathway antibodies  RHO GTPases Activate PKNs Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
Diseases associated with anti-PPP1R14A antibodyOrgans/Tissues associated with anti-PPP1R14A antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >16 publications with PPP1R14A and Disease Models, Animal
 Inflammation Antibodies  >13 publications with PPP1R14A and Inflammation
 Hypertension Antibodies  >11 publications with PPP1R14A and Hypertension
 Necrosis Antibodies  >9 publications with PPP1R14A and Necrosis
 Lung Diseases Antibodies  >8 publications with PPP1R14A and Lung Diseases
 Cardiovascular Diseases Antibodies  >8 publications with PPP1R14A and Cardiovascular Diseases
 Hypertrophy Antibodies  >4 publications with PPP1R14A and Hypertrophy
 Hyperplasia Antibodies  >4 publications with PPP1R14A and Hyperplasia
 Drug Hypersensitivity Antibodies  >4 publications with PPP1R14A and Drug Hypersensitivity
 Liver Diseases Antibodies  >3 publications with PPP1R14A and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >18 publications with PPP1R14A and Lung
 Heart Antibodies  >14 publications with PPP1R14A and Heart
 Intestine Antibodies  >12 publications with PPP1R14A and Intestine
 Brain Antibodies  >7 publications with PPP1R14A and Brain
 Stomach Antibodies  >5 publications with PPP1R14A and Stomach
 Embryonic Tissue Antibodies  >4 publications with PPP1R14A and Embryonic Tissue
 Uterus Antibodies  >3 publications with PPP1R14A and Uterus
 Nerve Antibodies  >3 publications with PPP1R14A and Nerve
 Eye Antibodies  >3 publications with PPP1R14A and Eye
 Prostate Antibodies  >2 publications with PPP1R14A and Prostate
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