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anti-PPP1R15B antibody :: Rabbit anti-Human PPP1R15B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2537787
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPP1R15B, Polyclonal Antibody

★Popular Item★
 Also Known As   

PPP1R15B Polyclonal Antibody

 Product Synonym Names    PPP1R15B; Protein phosphatase 1 regulatory subunit 15B
 Product Gene Name   

anti-PPP1R15B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2537787 Technical Datasheet    Technical Datasheet PDF
 OMIM    613257
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity purification
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 Immunogen    Synthesized peptide derived from the Internal region of human PPP1R15B.
 Buffer    PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-138534 / sc-138536
 Note    Centrifuge before opening to ensure complete recovery of vial contents.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PPP1R15B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPP1R15B antibody

   This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism.PPP1R15B (Protein Phosphatase 1 Regulatory Subunit 15B) is a Protein Coding gene. Diseases associated with PPP1R15B include Microcephaly, Short Stature, And Impaired Glucose Metabolism 2 and Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome. GO annotations related to this gene include protein serine/threonine phosphatase activity.
 Applications Tested/Suitable for anti-PPP1R15B antibody   

WB,IHC-p,ELISA

 Application Notes for anti-PPP1R15B antibody    WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000-1:10000
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 Western Blot (WB) of anti-PPP1R15B antibody    Western Blot analysis of NIH-3T3 cells with PPP1R15B Polyclonal Antibody.
anti-PPP1R15B antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PPP1R15B antibody    Immunohistochemistry of paraffin-embedded Human liver tissue using PPP1R15B Polyclonal Antibody at dilution of 1:100.
anti-PPP1R15B antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PPP1R15B. It may not necessarily be applicable to this product.
 NCBI GI #    613410232
 NCBI GeneID    84919
 NCBI Accession #    NP_116222.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_032833.4 [Other Products]
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 UniProt Secondary Accession #    Q53GQ4; Q658M2; Q6P156; Q96SN1 [Other Products]
 UniProt Related Accession #    Q5SWA1 [Other Products]
 Molecular Weight    Calculated MW: 78
Observed MW: 78
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 NCBI Official Full Name    protein phosphatase 1 regulatory subunit 15B
 NCBI Official Synonym Full Names    protein phosphatase 1 regulatory subunit 15B
 NCBI Official Symbol    PPP1R15B [Similar Products]
 NCBI Official Synonym Symbols   
CREP; MSSGM2
[Similar Products]
 NCBI Protein Information    protein phosphatase 1 regulatory subunit 15B
 UniProt Protein Name    Protein phosphatase 1 regulatory subunit 15B
 Protein Family    Protein phosphatase 1 regulatory
 UniProt Gene Name    PPP1R15B [Similar Products]
 UniProt Entry Name    PR15B_HUMAN
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 NCBI Summary for PPP1R15B    This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
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 UniProt Comments for PPP1R15B    PPP1R15B: Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Belongs to the PPP1R15 family.

Protein type: Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: protein phosphatase type 1 complex

Molecular Function: protein binding; protein serine/threonine phosphatase activity

Biological Process: ER overload response; response to hydrogen peroxide
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 Research Articles on PPP1R15B    1. CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPP1R15B antibodyOrgans/Tissues associated with anti-PPP1R15B antibody
 Reference Product  PubMed Publications
 ATF4 antibody  >1 publications with PPP1R15B and ATF4
 EIF2AK3 antibody  >1 publications with PPP1R15B and EIF2AK3
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with PPP1R15B and Liver
 Muscle Antibodies  >1 publications with PPP1R15B and Muscle
 Lung Antibodies  >1 publications with PPP1R15B and Lung
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