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anti-PPP1R8 antibody :: Rabbit anti-Human PPP1R8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045769
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPP1R8, Polyclonal Antibody

★Popular Item★
 Also Known As   

PPP1R8 Antibody

 Product Synonym Names    Nuclear inhibitor of protein phosphatase 1; NIPP-1; Protein phosphatase 1 regulatory inhibitor subunit 8; Activator of RNA decay; ARD-1; PPP1R8; ARD1; NIPP1
 Product Gene Name   

anti-PPP1R8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602636
 3D Structure    ModBase 3D Structure for Q12972
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Nuclear inhibitor of protein phosphatase 1 protein (1-209AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-67702 / sc-67703 / sc-67704 / sc-67705
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PPP1R8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPP1R8 antibody

   Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
 Applications Tested/Suitable for anti-PPP1R8 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-PPP1R8 antibody    Western blot
All lanes: PPP1R8 antibody at 1.11 ug/ml
Lane 1: PC-3 whole cell lysate
Lane 2: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39,23,14 kDa
Observed band size: 38 kDa

anti-PPP1R8 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PPP1R8 antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7045769 at dilution 1:100
anti-PPP1R8 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PPP1R8 antibody    Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7045769 at dilution 1:100
anti-PPP1R8 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-PPP1R8 antibody    Immunofluorescent analysis of hepg2 using MBS7045769 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PPP1R8 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for PPP1R8. It may not necessarily be applicable to this product.
 NCBI GI #    4506015
 NCBI GeneID    5511
 NCBI Accession #    NP_002704.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002713.3 [Other Products]
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 UniProt Primary Accession #    Q12972 [Other Products]
 UniProt Secondary Accession #    Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0 [Other Products]
 UniProt Related Accession #    Q12972 [Other Products]
 Molecular Weight    13,344 Da
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 NCBI Official Full Name    nuclear inhibitor of protein phosphatase 1 isoform gamma
 NCBI Official Synonym Full Names    protein phosphatase 1 regulatory subunit 8
 NCBI Official Symbol    PPP1R8 [Similar Products]
 NCBI Official Synonym Symbols   
ARD1; ARD-1; NIPP1; NIPP-1; PRO2047
[Similar Products]
 NCBI Protein Information    nuclear inhibitor of protein phosphatase 1
 UniProt Protein Name    Nuclear inhibitor of protein phosphatase 1
 UniProt Synonym Protein Names   
Protein phosphatase 1 regulatory inhibitor subunit 8Including the following 1 domains:Activator of RNA decay (EC:3.1.4.-)Alternative name(s):ARD-1
 Protein Family    Nuclear inhibitor of protein phosphatase
 UniProt Gene Name    PPP1R8 [Similar Products]
 UniProt Synonym Gene Names    ARD1; NIPP1; NIPP-1 [Similar Products]
 UniProt Entry Name    PP1R8_HUMAN
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 NCBI Summary for PPP1R8    This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PPP1R8    NIPP-1: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.-; Protein phosphatase, regulatory subunit; Inhibitor; Ribonuclease; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p35.3

Cellular Component: nuclear speck; nucleoplasm; nucleus

Molecular Function: protein binding; ribonuclease E activity; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: RNA catabolic process
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 Research Articles on PPP1R8    1. Data suggest overexpression of NIPP1 in HeLa cells causes induction of genes of mesenchymal lineage with reduction in cell proliferation; thus, key dephosphorylation events may be involved in epithelial-mesenchymal transition or transdifferentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-PPP1R8 antibodyOrgans/Tissues associated with anti-PPP1R8 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with PPP1R8 and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with PPP1R8 and Heart Diseases
 Liver Neoplasms Antibodies  >2 publications with PPP1R8 and Liver Neoplasms
 Adenocarcinoma Antibodies  >1 publications with PPP1R8 and Adenocarcinoma
 Kidney Diseases Antibodies  >1 publications with PPP1R8 and Kidney Diseases
 Hypertrophy Antibodies  >1 publications with PPP1R8 and Hypertrophy
 Inflammation Antibodies  >1 publications with PPP1R8 and Inflammation
 Fibrosis Antibodies  >1 publications with PPP1R8 and Fibrosis
 Hyperplasia Antibodies  >1 publications with PPP1R8 and Hyperplasia
 Necrosis Antibodies  >1 publications with PPP1R8 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >14 publications with PPP1R8 and Muscle
 Liver Antibodies  >6 publications with PPP1R8 and Liver
 Brain Antibodies  >5 publications with PPP1R8 and Brain
 Heart Antibodies  >4 publications with PPP1R8 and Heart
 Blood Antibodies  >2 publications with PPP1R8 and Blood
 Kidney Antibodies  >2 publications with PPP1R8 and Kidney
 Thymus Antibodies  >2 publications with PPP1R8 and Thymus
 Lymph Antibodies  >1 publications with PPP1R8 and Lymph
 Embryonic Tissue Antibodies  >1 publications with PPP1R8 and Embryonic Tissue
 Prostate Antibodies  >1 publications with PPP1R8 and Prostate
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