NP_002706.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,735 Da
NCBI Official Full Name
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
NCBI Official Synonym Full Names
protein phosphatase 2 catalytic subunit alpha
NCBI Protein Information
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
UniProt Protein Name
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
UniProt Synonym Protein Names
Replication protein C; RP-C
UniProt Synonym Gene Names
UniProt Entry Name
PP2AA_HUMAN
NCBI Summary for PPP2CA
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
UniProt Comments for PPP2CA
PPP2CA: ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: chromosome, pericentric region; cytosol; membrane; microtubule cytoskeleton; mitochondrion; nucleus; plasma membrane; protein phosphatase type 2A complex; spindle pole
Molecular Function: GABA receptor binding; metal ion binding; phosphoprotein phosphatase activity; protein binding; protein C-terminus binding
Biological Process: apoptosis; ceramide metabolic process; inactivation of MAPK activity; meiotic cell cycle; mesoderm development; mitotic nuclear envelope reassembly; mRNA catabolic process, nonsense-mediated decay; negative regulation of cell growth; negative regulation of tyrosine phosphorylation of Stat3 protein; protein amino acid dephosphorylation; regulation of cell adhesion; regulation of cell differentiation; regulation of DNA replication; regulation of growth; regulation of transcription, DNA-dependent; regulation of Wnt receptor signaling pathway; response to organic substance; RNA splicing; second-messenger-mediated signaling
Research Articles on PPP2CA
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-PPP2CA antibody
Pathways associated with anti-PPP2CA antibody
Diseases associated with anti-PPP2CA antibody
Organs/Tissues associated with anti-PPP2CA antibody
|