NP_002707.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,214 Da
NCBI Official Full Name
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a
NCBI Official Synonym Full Names
protein phosphatase 2, regulatory subunit A, beta
NCBI Protein Information
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A, subunit A, R1-beta isoform; PP2A, subunit A, PR65-beta isoform; protein phosphatase 2, structural/regulatory subunit A, beta; protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
UniProt Protein Name
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
UniProt Synonym Protein Names
PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta
UniProt Entry Name
2AAB_HUMAN
NCBI Summary for PPP2R1B
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
UniProt Comments for PPP2R1B
PPP2R1B: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Belongs to the phosphatase 2A regulatory subunit A family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 11q23.2
Cellular Component: lipid raft
Molecular Function: protein binding
Disease: Lung Cancer
Research Articles on PPP2R1B
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Products associated with anti-PPP2R1B antibody
Pathways associated with anti-PPP2R1B antibody
Diseases associated with anti-PPP2R1B antibody
Organs/Tissues associated with anti-PPP2R1B antibody
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