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anti-PPP2R3C antibody :: Rabbit anti-Human, Mouse PPP2R3C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7043685
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPP2R3C, Polyclonal Antibody

★Popular Item★
 Also Known As   

PPP2R3C Antibody

 Product Synonym Names    Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C; PPP2R3C; C14orf10; G5PR
 Product Gene Name   

anti-PPP2R3C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    615902
 3D Structure    ModBase 3D Structure for Q969Q6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma protein (N-160AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PPP2R3C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPP2R3C antibody

   May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.
 Applications Tested/Suitable for anti-PPP2R3C antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-PPP2R3C antibody    Western blot
All lanes: PPP2R3C antibody at 3.76 ug/ml
Lane 1: Mouse stomach tissue
Lane 2: Mouse brain tissue
Lane 3: A431 whole cell lysate
Lane 4: Jurkat whole cell lysate
Lane 5: A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54,40 kDa
Observed band size: 53,30 kDa

anti-PPP2R3C antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PPP2R3C antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7043685 at dilution of 1:100
anti-PPP2R3C antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PPP2R3C antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7043685 at dilution of 1:100
anti-PPP2R3C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PPP2R3C. It may not necessarily be applicable to this product.
 NCBI GI #    762205515
 NCBI GeneID    55012
 NCBI Accession #    NP_001292084.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001305155.1 [Other Products]
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 UniProt Primary Accession #    Q969Q6 [Other Products]
 UniProt Secondary Accession #    Q5GJ55; Q5GJ56; Q6P4G2; Q86TZ3; Q9NWR9; B4DEN7; D3DS97; D3DS98 [Other Products]
 UniProt Related Accession #    Q969Q6 [Other Products]
 Molecular Weight    39,806 Da
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 NCBI Official Full Name    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform 2
 NCBI Official Synonym Full Names    protein phosphatase 2 regulatory subunit B''gamma
 NCBI Official Symbol    PPP2R3C [Similar Products]
 NCBI Official Synonym Symbols   
G4-1; G5pr; C14orf10
[Similar Products]
 NCBI Protein Information    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
 UniProt Protein Name    Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
 UniProt Synonym Protein Names   
Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
 Protein Family    Serine/threonine-protein phosphatase
 UniProt Gene Name    PPP2R3C [Similar Products]
 UniProt Synonym Gene Names    C14orf10; G5PR [Similar Products]
 UniProt Entry Name    P2R3C_HUMAN
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 NCBI Summary for PPP2R3C    This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
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 UniProt Comments for PPP2R3C    PPP2R3C: May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 14q13.2

Cellular Component: centrosome; spindle

Molecular Function: protein binding

Biological Process: B cell homeostasis; cortical cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; positive regulation of B cell differentiation; T cell homeostasis
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 Research Articles on PPP2R3C    1. Knockdown of PP5 and/or PPP2R3C increased P-gp expression and lowered the sensitivity to vincristine and doxorubicin. Consequently, results indicate that PP5/PPP2R3C negatively regulates P-gp expression and function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PPP2R3C antibodyDiseases associated with anti-PPP2R3C antibody
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Sphingolipid Signaling Pathway antibodies  Sphingolipid Signaling Pathway Diagram
 Sphingolipid Signaling Pathway antibodies  Sphingolipid Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Fever Antibodies  >1 publications with PPP2R3C and Fever
 Lung Neoplasms Antibodies  >1 publications with PPP2R3C and Lung Neoplasms
 Necrosis Antibodies  >1 publications with PPP2R3C and Necrosis
Organs/Tissues associated with anti-PPP2R3C antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1 publications with PPP2R3C and Vascular
 Lung Antibodies  >1 publications with PPP2R3C and Lung
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