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anti-PPT1 antibody :: Rabbit anti-Human, Rat PPT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052297
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPT1, Polyclonal Antibody

★Popular Item★
 Also Known As   

PPT1 Antibody

 Product Synonym Names    Palmitoyl-protein thioesterase 1; PPT-1; Palmitoyl-protein hydrolase 1; PPT1; PPT
 Product Gene Name   

anti-PPT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L42809 Genomic DNA
 3D Structure    ModBase 3D Structure for P50897
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Palmitoyl-protein thioesterase 1 protein (100-258AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PPT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PPT1 antibody

   Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
 Applications Tested/Suitable for anti-PPT1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PPT1 antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
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 Western Blot (WB) of anti-PPT1 antibody    Western Blot
Positive WB detected in: A549 whole cell lysate,HEK293 whole cell lysate,HL-60 whole cell lysate,Rat liver tissue
All lanes: PPT1 antibody at 3.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35,24 KDa
Observed band size: 35 KDa

anti-PPT1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PPT1 antibody    Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7052297 at dilution of 1:100
anti-PPT1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PPT1. It may not necessarily be applicable to this product.
 NCBI GI #    4506031
 NCBI GeneID    5538
 NCBI Accession #    NP_000301.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000310.3 [Other Products]
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 UniProt Primary Accession #    P50897 [Other Products]
 UniProt Secondary Accession #    Q6FGQ4; B4DY24 [Other Products]
 UniProt Related Accession #    P50897 [Other Products]
 Molecular Weight    23,094 Da
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 NCBI Official Full Name    palmitoyl-protein thioesterase 1 isoform 1
 NCBI Official Synonym Full Names    palmitoyl-protein thioesterase 1
 NCBI Official Symbol    PPT1 [Similar Products]
 NCBI Official Synonym Symbols   
PPT; CLN1; INCL
[Similar Products]
 NCBI Protein Information    palmitoyl-protein thioesterase 1
 UniProt Protein Name    Palmitoyl-protein thioesterase 1
 UniProt Synonym Protein Names   
Palmitoyl-protein hydrolase 1
 Protein Family    Palmitoyl-protein thioesterase
 UniProt Gene Name    PPT1 [Similar Products]
 UniProt Synonym Gene Names    ; PPT-1 [Similar Products]
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 NCBI Summary for PPT1    The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008]
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 UniProt Comments for PPT1    PPT1: Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. Defects in PPT1 are the cause of neuronal ceroid lipofuscinosis type 1 (CLN1). A form of neuronal ceroid lipofuscinosis with variable age at onset. Infantile, late- infantile, juvenile, and adult onset have been reported. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN1 is referred to as granular osmiophilic deposits (GROD). Belongs to the palmitoyl-protein thioesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.2.22; Hydrolase; Lipid Metabolism - fatty acid elongation in mitochondria

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: axon; cytosol; extracellular region; Golgi apparatus; lipid raft; lysosomal lumen; lysosome; membrane; nucleus; synaptic vesicle

Molecular Function: palmitoyl-(protein) hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding

Biological Process: brain development; cofactor metabolic process; cofactor transport; lipid catabolic process; lipid raft organization and biogenesis; lysosomal lumen acidification; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of neuron apoptosis; nervous system development; neuron development; pinocytosis; positive regulation of pinocytosis; positive regulation of receptor-mediated endocytosis; protein depalmitoylation; protein transport; receptor-mediated endocytosis; sphingolipid catabolic process; synaptic transmission

Disease: Ceroid Lipofuscinosis, Neuronal, 1
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 Research Articles on PPT1    1. we reveal the existence of a positive feedback loop, where palmitoylation of PPT1 results in decreased activity and subsequent elevation in the amount of palmitoylated proteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPT1 antibodyPathways associated with anti-PPT1 antibody
 Reference Product  PubMed Publications
 CLN3 antibody  >40 publications with PPT1 and CLN3
 CLN6 antibody  >24 publications with PPT1 and CLN6
 TPP1 antibody  >22 publications with PPT1 and TPP1
 Products by Pathway  Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with anti-PPT1 antibodyOrgans/Tissues associated with anti-PPT1 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >36 publications with PPT1 and Disease Models, Animal
 Atrophy Antibodies  >14 publications with PPT1 and Atrophy
 Inflammation Antibodies  >5 publications with PPT1 and Inflammation
 Necrosis Antibodies  >3 publications with PPT1 and Necrosis
 Cardiovascular Diseases Antibodies  >2 publications with PPT1 and Cardiovascular Diseases
 Cognition Disorders Antibodies  >1 publications with PPT1 and Cognition Disorders
 Neoplasm Metastasis Antibodies  >1 publications with PPT1 and Neoplasm Metastasis
 Infertility, Male Antibodies  >1 publications with PPT1 and Infertility, Male
 Liver Diseases Antibodies  >1 publications with PPT1 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with PPT1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with PPT1 and Brain
 Blood Antibodies  >22 publications with PPT1 and Blood
 Nerve Antibodies  >20 publications with PPT1 and Nerve
 Eye Antibodies  >16 publications with PPT1 and Eye
 Skin Antibodies  >8 publications with PPT1 and Skin
 Muscle Antibodies  >7 publications with PPT1 and Muscle
 Bone Antibodies  >5 publications with PPT1 and Bone
 Spleen Antibodies  >4 publications with PPT1 and Spleen
 Kidney Antibodies  >4 publications with PPT1 and Kidney
 Heart Antibodies  >4 publications with PPT1 and Heart
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