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anti-PRC1 antibody :: Rabbit PRC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151284
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRC1, Polyclonal Antibody

 Also Known As   

PRC1 Antibody

 Product Synonym Names    PRC1; ASE1; Protein regulator of cytokinesis 1; protein regulator of cytokinesis 1
 Product Gene Name   

anti-PRC1 antibody

[Similar Products]
 Antibody/Peptide Pairs    PRC1 peptide (MBS152868) is used for blocking the activity of PRC1 antibody (MBS151284)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603484
 3D Structure    ModBase 3D Structure for O43663
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.
 Purity/Purification    PRC1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    PRC1 antibody was raised against a 19 amino acid synthetic peptide near the center of human PRC1.
 Buffer    PRC1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    PRC1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-PRC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PRC1 antibody

   PRC1 Antibody: PRC1 (Protein Regulator of Cytokinesis 1) is a key regulator of cytokinesis and has been identified as a substrate for several cyclin-dependent kinases (CDKs). High levels of PRC1 expression occurs during S and G2/M and drops dramatically after mitosis exit and G1 entry. It is located in the nucleus during interphase and binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis.
 Applications Tested/Suitable for anti-PRC1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-PRC1 antibody    PRC1 antibody can be used for detection of Prc1 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 2.5 mug/mL.
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 Western Blot (WB) of anti-PRC1 antibody    Western blot analysis of PRC1 in human skeletal muscle tissue lysate with Prc1 antibody at (A) 0.5 μg/ml and (B) 1 μg/mL.
anti-PRC1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-PRC1 antibody    Immunofluorescence of PRC1 in mouse skeletal muscle tissue with PRC1 antibody at 20 μg/mL.
anti-PRC1 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-PRC1 antibody    Immunohistochemistry of PRC1 in mouse skeletal muscle tissue with PRC1 antibody at 2.5 μg/mL.
anti-PRC1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PRC1. It may not necessarily be applicable to this product.
 NCBI GI #    4506039
 NCBI GeneID    9055
 NCBI Accession #    NP_003972 [Other Products]
 NCBI GenBank Nucleotide #    NM_003981.3 [Other Products]
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 UniProt Primary Accession #    O43663 [Other Products]
 UniProt Secondary Accession #    Q9BSB6; A6NC44; B4DLR1; H9KV59 [Other Products]
 UniProt Related Accession #    O43663 [Other Products]
 Molecular Weight    70,191 Da
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 NCBI Official Full Name    protein regulator of cytokinesis 1 isoform 1
 NCBI Official Synonym Full Names    protein regulator of cytokinesis 1
 NCBI Official Symbol    PRC1 [Similar Products]
 NCBI Official Synonym Symbols   
ASE1
[Similar Products]
 NCBI Protein Information    protein regulator of cytokinesis 1; PRC1; protein regulating cytokinesis 1; anaphase spindle elongation 1 homolog
 UniProt Protein Name    Protein regulator of cytokinesis 1
 Protein Family    Protein regulator of cytokinesis
 UniProt Gene Name    PRC1 [Similar Products]
 UniProt Entry Name    PRC1_HUMAN
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 NCBI Summary for PRC1    This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
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 UniProt Comments for PRC1    PRC1: translocates to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. Acts as a microtubule-binding and bundling protein both in vivo and vitro. Interacts with the C-terminal Rho-GAP domain and the basic region of MgcRacGAP. The interaction with MgcRacGAP inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23 during late mitosis.

Protein type: Motility/polarity/chemotaxis; Cell cycle regulation; Microtubule-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: microtubule cytoskeleton; nucleoplasm; spindle pole; spindle microtubule; cytoplasm; plasma membrane; spindle; nucleus

Molecular Function: identical protein binding; protein binding; kinesin binding; microtubule binding; protein kinase binding

Biological Process: mitotic spindle elongation; cytokinesis
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 Research Articles on PRC1    1. The presence of CBX4 or CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRC1 antibodyDiseases associated with anti-PRC1 antibody
 Reference Product  PubMed Publications
 PLK1 antibody  >12 publications with PRC1 and PLK1
 CDK1 antibody  >9 publications with PRC1 and CDK1
 KIF4A antibody  >6 publications with PRC1 and KIF4A
 KIF14 antibody  >5 publications with PRC1 and KIF14
 KIF23 antibody  >4 publications with PRC1 and KIF23
 AURKA antibody  >2 publications with PRC1 and AURKA
 BIRC5 antibody  >2 publications with PRC1 and BIRC5
 RACGAP1 antibody  >1 publications with PRC1 and RACGAP1
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >24 publications with PRC1 and Carcinoma
 Adenocarcinoma Antibodies  >15 publications with PRC1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >13 publications with PRC1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >11 publications with PRC1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >6 publications with PRC1 and Lung Neoplasms
 Nervous System Diseases Antibodies  >6 publications with PRC1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >5 publications with PRC1 and Neoplasms, Experimental
 Brain Diseases Antibodies  >5 publications with PRC1 and Brain Diseases
 Lung Diseases Antibodies  >5 publications with PRC1 and Lung Diseases
 Carcinoma, Squamous Cell Antibodies  >4 publications with PRC1 and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-PRC1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with PRC1 and Brain
 Blood Antibodies  >16 publications with PRC1 and Blood
 Liver Antibodies  >12 publications with PRC1 and Liver
 Lung Antibodies  >8 publications with PRC1 and Lung
 Embryonic Tissue Antibodies  >8 publications with PRC1 and Embryonic Tissue
 Vascular Antibodies  >8 publications with PRC1 and Vascular
 Bone Antibodies  >8 publications with PRC1 and Bone
 Ovary Antibodies  >8 publications with PRC1 and Ovary
 Pancreas Antibodies  >7 publications with PRC1 and Pancreas
 Muscle Antibodies  >6 publications with PRC1 and Muscle
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