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anti-PRDM16 antibody :: Rabbit PRDM16 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150905
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRDM16, Polyclonal Antibody

★Popular Item★
 Also Known As   

PRDM16 Antibody

 Product Synonym Names    PRDM16; MEL1; LVNC8; PFM13; CMD1LL; KIAA1675; MEL1; PR domain zinc finger protein 16; PR domain-containing protein 16; PR domain containing 16
 Product Gene Name   

anti-PRDM16 antibody

[Similar Products]
 Antibody/Peptide Pairs    PRDM16 peptide (MBS152900) is used for blocking the activity of PRDM16 antibody (MBS150905)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615373
 3D Structure    ModBase 3D Structure for Q9HAZ2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    PRDM16 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    PRDM16 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PRDM16.
 Buffer    PRDM16 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    PRDM16 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-PRDM16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PRDM16 antibody

   PRDM16 Antibody: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
 Applications Tested/Suitable for anti-PRDM16 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-PRDM16 antibody    PRDM16 antibody can be used for detection of PRDM16 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-PRDM16 antibody    Western blot analysis of PRDM16 in rat brain tissue lysate with PRDM16 antibody at (A) 1 and (B) 2 μg/mL.
anti-PRDM16 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-PRDM16 antibody    Immunofluorescence of PRDM16 in Human Brain cells with PRDM16 antibody at 20 μg/mL.
anti-PRDM16 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-PRDM16 antibody    Immunohistochemistry of PRDM16 in rat brain tissue with PRDM16 antibody at 2.5 μg/mL.
anti-PRDM16 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PRDM16. It may not necessarily be applicable to this product.
 NCBI GI #    55665817
 NCBI GeneID    63976
 NCBI Accession #    CAH71530 [Other Products]
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 UniProt Primary Accession #    Q9HAZ2 [Other Products]
 UniProt Secondary Accession #    Q8WYJ9; Q9C0I8; A6NHQ8; B1AJP7; B1AJP8; B1AJP9; B1WB48 [Other Products]
 UniProt Related Accession #    Q9HAZ2 [Other Products]
 Molecular Weight    120,338 Da
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 NCBI Official Synonym Full Names    PR domain containing 16
 NCBI Official Symbol    PRDM16 [Similar Products]
 NCBI Official Synonym Symbols   
MEL1; LVNC8; PFM13; CMD1LL
[Similar Products]
 NCBI Protein Information    PR domain zinc finger protein 16
 UniProt Protein Name    PR domain zinc finger protein 16
 UniProt Synonym Protein Names   
PR domain-containing protein 16; Transcription factor MEL1; MDS1/EVI1-like gene 1
 Protein Family    PR domain zinc finger protein
 UniProt Gene Name    PRDM16 [Similar Products]
 UniProt Synonym Gene Names    KIAA1675; MEL1; PFM13; MDS1/EVI1-like gene 1 [Similar Products]
 UniProt Entry Name    PRD16_HUMAN
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 NCBI Summary for PRDM16    The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRDM16    PRDM16: binds DNA and functions as a transcriptional regulator. A repressor of TGF-beta signaling. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Interacts with HDAC1, SKI, SMAD2 and SMAD3; the interaction with SKI promotes the recruitment of SMAD3-HDAC1 complex on the promoter of TGF-beta target genes. A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia. Four human isoforms are produced by alternative promoter usage and alternative splicing

Protein type: Methyltransferase, protein lysine, predicted; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 1p36.23-p33

Cellular Component: transcriptional repressor complex; nucleus

Molecular Function: protein binding; transcription activator binding; sequence-specific DNA binding; metal ion binding; transcription coactivator activity; SMAD binding

Biological Process: regulation of cellular respiration; tongue development; neurogenesis; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; white fat cell differentiation; brown fat cell differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of granulocyte differentiation

Disease: Left Ventricular Noncompaction 8
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 Research Articles on PRDM16    1. EVI1 and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations have roles in Japanese pediatric acute myeloid leukemia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRDM16 antibodyDiseases associated with anti-PRDM16 antibody
 Reference Product  PubMed Publications
 UCP1 antibody  >47 publications with PRDM16 and UCP1
 RPN1 antibody  >4 publications with PRDM16 and RPN1
 SMAD3 antibody  >4 publications with PRDM16 and SMAD3
 SKI antibody  >3 publications with PRDM16 and SKI
 SMAD2 antibody  >2 publications with PRDM16 and SMAD2
 LMO2 antibody  >1 publications with PRDM16 and LMO2
 SETBP1 antibody  >1 publications with PRDM16 and SETBP1
 HES1 antibody  >1 publications with PRDM16 and HES1
 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >8 publications with PRDM16 and Diabetes Mellitus
 Weight Gain Antibodies  >7 publications with PRDM16 and Weight Gain
 Headache Antibodies  >7 publications with PRDM16 and Headache
 Brain Diseases Antibodies  >6 publications with PRDM16 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with PRDM16 and Cell Transformation, Neoplastic
 Migraine Disorders Antibodies  >5 publications with PRDM16 and Migraine Disorders
 Fatty Liver Antibodies  >4 publications with PRDM16 and Fatty Liver
 Inflammation Antibodies  >4 publications with PRDM16 and Inflammation
 Liver Diseases Antibodies  >3 publications with PRDM16 and Liver Diseases
 Cardiovascular Abnormalities Antibodies  >3 publications with PRDM16 and Cardiovascular Abnormalities
Organs/Tissues associated with anti-PRDM16 antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >13 publications with PRDM16 and Embryonic Tissue
 Heart Antibodies  >11 publications with PRDM16 and Heart
 Brain Antibodies  >11 publications with PRDM16 and Brain
 Liver Antibodies  >8 publications with PRDM16 and Liver
 Skin Antibodies  >4 publications with PRDM16 and Skin
 Lung Antibodies  >3 publications with PRDM16 and Lung
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