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anti-PRDX1 antibody :: Goat PRDX1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422240
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRDX1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-PRDX1 Antibody

 Product Synonym Names    PRDX1; peroxiredoxin 1; MSP23; NKEFA; PAG; PAGA; PAGB; PRX1; PRXI; TDPX2; natural killer-enhancing factor A; proliferation-associated gene A; thioredoxin-dependent peroxide reductase 2; PRDX1 antibody; peroxiredoxin 1 antibody; MSP23 antibody; NKEFA antibody; PAG antibody; PAGA antibody; PAGB antibody; PRX1 antibody; PRXI antibody; TDPX2 antibody; natural killer-enhancing factor A antibody; proliferation-associated gene A antibody; thioredoxin-dependent peroxide reductase 2 antibody
 Product Gene Name   

anti-PRDX1 antibody

[Similar Products]
 Antibody/Peptide Pairs    PRDX1 peptide (MBS426313) is used for blocking the activity of PRDX1 antibody (MBS422240)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SDPKRTIAQD YG
 OMIM    176763
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    0.5 mg/ml (lot specific)
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 Immunogen    Peptide with sequence C-SDPKRTIAQDYG, from the internal region of the protein sequence according to NP_859048.1.
 Note    Reported variants represent identical protein (NP_002565.1, NP_859047.1, NP_859048.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PRDX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PRDX1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PRDX1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx.23 to 24kDa band observed in lysates of cell lines HEK293, A431 and HepG2 (calculated MW of 22.1kDa according to NP_859048.1). Recommended concentration: 0.01-0.03ug/ml.
IHC: Paraffin embedded Human Thyroid Gland and Placenta. Recommended concentration: 2.5ug/ml.
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 Western Blot (WB) of anti-PRDX1 antibody    (0. 01ug/ml) staining of HepG2 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-PRDX1 antibody Western Blot (WB) (WB) image
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 IHC of anti-PRDX1 antibody    (2.5?g/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-PRDX1 antibody IHC image
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 IHC of anti-PRDX1 antibody    (2.5?g/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-PRDX1 antibody IHC image
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NCBI/Uniprot data below describe general gene information for PRDX1. It may not necessarily be applicable to this product.
 NCBI GI #    32455266
 NCBI GeneID    5052
 NCBI Accession #    NP_859048.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_181697.2 [Other Products]
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 UniProt Secondary Accession #    P35703; Q2V576; Q5T154; Q5T155; B5BU26; D3DPZ8 [Other Products]
 UniProt Related Accession #    Q06830 [Other Products]
 Molecular Weight    22,110 Da
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 NCBI Official Full Name    peroxiredoxin-1
 NCBI Official Synonym Full Names    peroxiredoxin 1
 NCBI Official Symbol    PRDX1 [Similar Products]
 NCBI Official Synonym Symbols   
PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A
[Similar Products]
 NCBI Protein Information    peroxiredoxin-1
 UniProt Protein Name    Peroxiredoxin-1
 UniProt Synonym Protein Names   
Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
 Protein Family    Peroxiredoxin
 UniProt Gene Name    PRDX1 [Similar Products]
 UniProt Synonym Gene Names    PAGA; PAGB; TDPX2; NKEF-A; PAG [Similar Products]
 UniProt Entry Name    PRDX1_HUMAN
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 NCBI Summary for PRDX1    This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
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 UniProt Comments for PRDX1    PRDX1: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression.

Protein type: EC 1.11.1.15; Oxidoreductase; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: cytoplasm; cytosol; extracellular space; melanosome; mitochondrion; myelin sheath; nucleus

Molecular Function: identical protein binding; peroxidase activity; protein binding; thioredoxin peroxidase activity

Biological Process: cell proliferation; erythrocyte homeostasis; hydrogen peroxide catabolic process; natural killer cell mediated cytotoxicity; regulation of NF-kappaB import into nucleus; regulation of stress-activated MAPK cascade; removal of superoxide radicals; response to reactive oxygen species; retinal homeostasis; skeletal development
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 Research Articles on PRDX1    1. PRDX1 was overexpressed in the tumor tissues of liver cancer and served as an independent poor prognostic factor for overall survival. PRDX1 can be modified by small ubiquitin-like modifier to play specific roles in hepatocarcinogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRDX1 antibodyPathways associated with anti-PRDX1 antibody
 Reference Product  PubMed Publications
 PRDX2 antibody  >48 publications with PRDX1 and PRDX2
 PRDX5 antibody  >18 publications with PRDX1 and PRDX5
 SOD1 antibody  >15 publications with PRDX1 and SOD1
 MYC antibody  >11 publications with PRDX1 and MYC
 TXN antibody  >8 publications with PRDX1 and TXN
 SRXN1 antibody  >8 publications with PRDX1 and SRXN1
 UBC antibody  >1 publications with PRDX1 and UBC
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 TP53 Regulates Metabolic Genes Pathway antibodies  TP53 Regulates Metabolic Genes Pathway Diagram
Diseases associated with anti-PRDX1 antibodyOrgans/Tissues associated with anti-PRDX1 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >24 publications with PRDX1 and Lung Diseases
 Inflammation Antibodies  >22 publications with PRDX1 and Inflammation
 Disease Models, Animal Antibodies  >17 publications with PRDX1 and Disease Models, Animal
 Liver Diseases Antibodies  >17 publications with PRDX1 and Liver Diseases
 Lung Neoplasms Antibodies  >16 publications with PRDX1 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >14 publications with PRDX1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >14 publications with PRDX1 and Nervous System Diseases
 Necrosis Antibodies  >14 publications with PRDX1 and Necrosis
 Breast Neoplasms Antibodies  >10 publications with PRDX1 and Breast Neoplasms
 Lung Injury Antibodies  >9 publications with PRDX1 and Lung Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with PRDX1 and Blood
 Liver Antibodies  >30 publications with PRDX1 and Liver
 Lung Antibodies  >29 publications with PRDX1 and Lung
 Brain Antibodies  >23 publications with PRDX1 and Brain
 Vascular Antibodies  >21 publications with PRDX1 and Vascular
 Nerve Antibodies  >12 publications with PRDX1 and Nerve
 Muscle Antibodies  >12 publications with PRDX1 and Muscle
 Kidney Antibodies  >12 publications with PRDX1 and Kidney
 Heart Antibodies  >9 publications with PRDX1 and Heart
 Spinal Cord Antibodies  >7 publications with PRDX1 and Spinal Cord
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