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anti-PRDX2 antibody :: Rabbit PRDX2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9206519
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRDX2, Polyclonal Antibody

★Popular Item★
 Also Known As   

PRDX2 Antibody (Center)

 Product Synonym Names    Peroxiredoxin-2; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; PRDX2; NKEFB; TDPX1
 Product Gene Name   

anti-PRDX2 antibody

[Similar Products]
 Antibody/Peptide Pairs    PRDX2 peptide (MBS9224950) is used for blocking the activity of PRDX2 antibody (MBS9206519)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    98-127
 OMIM    600538
 3D Structure    ModBase 3D Structure for P32119
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Monkey)
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 Specificity    This PRDX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-127 amino acids from the Central region of human PRDX2.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
 Concentration    Vial Concentration: 2 (lot specific)
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 Antigen Type    Synthetic Peptide
 Crown Antibody    Yes
 Primary Accession    P32119
 Other Accession    Q2PFZ3
 Precautions    PRDX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
 Cellular Location    Cytoplasm.
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-PRDX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PRDX2 antibody

   PRDX2 is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. This protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms.

Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
 Product Categories/Family for anti-PRDX2 antibody    Crown Antibodies; Cancer; Cell Biology; Metabolism; Neuroscience; Signal Transduction
 Applications Tested/Suitable for anti-PRDX2 antibody   

ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)

 Application Notes for anti-PRDX2 antibody    WB~~1:1000
IHC-P~~1:50~100
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 Western Blot (WB) of anti-PRDX2 antibody    PRDX2 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the PRDX2 antibody detected the PRDX2 protein (arrow).
anti-PRDX2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PRDX2 antibody    Formalin-fixed and paraffin-embedded human brain tissue reacted with PRDX2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-PRDX2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PRDX2. It may not necessarily be applicable to this product.
 NCBI GI #    32189392
 NCBI GeneID    7001
 NCBI Accession #    NP_005800.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005809.5 [Other Products]
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 UniProt Primary Accession #    P32119 [Other Products]
 UniProt Secondary Accession #    P31945; P32118; P35701; Q6FHG4; Q92763; Q9UC23; A8K0C0 [Other Products]
 UniProt Related Accession #    P32119 [Other Products]
 Molecular Weight    21892
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 NCBI Official Full Name    peroxiredoxin-2
 NCBI Official Synonym Full Names    peroxiredoxin 2
 NCBI Official Symbol    PRDX2 [Similar Products]
 NCBI Official Synonym Symbols   
PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
[Similar Products]
 NCBI Protein Information    peroxiredoxin-2
 UniProt Protein Name    Peroxiredoxin-2
 UniProt Synonym Protein Names   
Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1
 Protein Family    Peroxiredoxin
 UniProt Gene Name    PRDX2 [Similar Products]
 UniProt Synonym Gene Names    NKEFB; TDPX1; NKEF-B; TSA [Similar Products]
 UniProt Entry Name    PRDX2_HUMAN
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 NCBI Summary for PRDX2    This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
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 UniProt Comments for PRDX2    PRDX2: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Three splice-variant isoforms have been identified.

Protein type: Oxidoreductase; EC 1.11.1.15

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol

Molecular Function: antioxidant activity; thioredoxin peroxidase activity

Biological Process: regulation of apoptosis; response to reactive oxygen species; removal of superoxide radicals; hydrogen peroxide catabolic process; negative regulation of neuron apoptosis; response to oxidative stress; negative regulation of apoptosis
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Product References and Citations for anti-PRDX2 antibody

   Engstrom,K.S., et.al., Mutat. Res. (2009)
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 Research Articles on PRDX2    1. two placental proteins, Prx3 and Prx4, may act as new placental immune targets.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRDX2 antibodyPathways associated with anti-PRDX2 antibody
 Reference Product  PubMed Publications
 PRDX1 antibody  >41 publications with PRDX2 and PRDX1
 PRDX6 antibody  >17 publications with PRDX2 and PRDX6
 PRDX5 antibody  >13 publications with PRDX2 and PRDX5
 SOD1 antibody  >12 publications with PRDX2 and SOD1
 GPX4 antibody  >6 publications with PRDX2 and GPX4
 TXN antibody  >3 publications with PRDX2 and TXN
 PARK7 antibody  >1 publications with PRDX2 and PARK7
 Products by Pathway  Pathway Diagram
 Benzoate Degradation Pathway antibodies  Benzoate Degradation Pathway Diagram
 Benzoate Degradation Pathway antibodies  Benzoate Degradation Pathway Diagram
 Benzoate Degradation Pathway antibodies  Benzoate Degradation Pathway Diagram
 Benzoate Degradation Pathway antibodies  Benzoate Degradation Pathway Diagram
 Benzoate Degradation Pathway antibodies  Benzoate Degradation Pathway Diagram
 Benzoate Degradation Pathway antibodies  Benzoate Degradation Pathway Diagram
 Benzoate Degradation Pathway antibodies  Benzoate Degradation Pathway Diagram
Diseases associated with anti-PRDX2 antibodyOrgans/Tissues associated with anti-PRDX2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >19 publications with PRDX2 and Carcinoma
 Inflammation Antibodies  >12 publications with PRDX2 and Inflammation
 Nervous System Diseases Antibodies  >10 publications with PRDX2 and Nervous System Diseases
 Liver Diseases Antibodies  >7 publications with PRDX2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >7 publications with PRDX2 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >7 publications with PRDX2 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >5 publications with PRDX2 and Lung Neoplasms
 Liver Neoplasms Antibodies  >5 publications with PRDX2 and Liver Neoplasms
 Necrosis Antibodies  >4 publications with PRDX2 and Necrosis
 Leukemia, Myeloid Antibodies  >4 publications with PRDX2 and Leukemia, Myeloid
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >55 publications with PRDX2 and Blood
 Brain Antibodies  >16 publications with PRDX2 and Brain
 Vascular Antibodies  >15 publications with PRDX2 and Vascular
 Liver Antibodies  >14 publications with PRDX2 and Liver
 Kidney Antibodies  >11 publications with PRDX2 and Kidney
 Bone Antibodies  >8 publications with PRDX2 and Bone
 Heart Antibodies  >8 publications with PRDX2 and Heart
 Muscle Antibodies  >8 publications with PRDX2 and Muscle
 Eye Antibodies  >7 publications with PRDX2 and Eye
 Lung Antibodies  >7 publications with PRDX2 and Lung
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