Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TTR rightarrow Polyclonal TTR  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Cytochrome P450 11A1 (CYP11A1) ELISA Kit
 • AKT1 Antibody
 • Human Immunodeficiency Virus Type 1&2 (HIV 1-2) p24 Antibody
 • endothelin 1 (EDN1) ELISA Kit
 • TLR1 cDNA Clone
 • Ophiostoma ulmi Cerato-ulmin (CU) Recombinant Protein
 • TBG ELISA Kit
 • LAMININ Purified Protein
 • SPARC cDNA Clone
 • Myoglobin (MB) ELISA Kit
 • CDX2 Antibody
 • L-amino-acid oxidase (LAAO) Recombinant Protein
 • Caspase 3, Active-Cleaved (CASP3) Antibody
 • MGMT Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TTR antibody :: Sheep PREALBUMIN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS222489 anti-TTR antibody
Unit / Price
1 mL  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PREALBUMIN (TTR), Polyclonal Antibody

 Also Known As   

SHEEP ANTI HUMAN PREALBUMIN

 Product Gene Name   

anti-TTR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    105210
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
Section Bar
 Specificity    This item recognises prealbumin, also known as transthyretin, a homotetrameric serum and cerebrospinal fluid protein which acts as a carrier for the thyroid hormone thyroxine. Each monomer is a 127 amino acid polypeptide. Prealbumin is synthesised principally in the liver and choroid plexus from where is is secreted into the serum and cerebrospinal fluid respectively.
 Form/Format    Serum
Serum - liquid
Section Bar
 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
 Target Species    Human
Section Bar
 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
 Other Notes    Small volumes of anti-TTR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-TTR antibody

   MBS222489 recognises prealbumin, also known as transthyretin, a homotetrameric serum and cerebrospinal fluid protein which acts as a carrier for the thyroid hormone thyroxine. Each monomer is a 127 amino acid polypeptide. Prealbumin is synthesised principally in the liver and choroid plexus from where is is secreted into the serum and cerebrospinal fluid respectively.
 Applications Tested/Suitable for anti-TTR antibody   

ELISA (EIA)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TTR. It may not necessarily be applicable to this product.
 NCBI GI #    4507725
 NCBI GeneID    7276
 NCBI Accession #    NP_000362.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000371.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q549C7; Q6IB96; Q9UBZ6; Q9UCM9 [Other Products]
 UniProt Related Accession #    P02766 [Other Products]
 Molecular Weight    55kDa [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    transthyretin
 NCBI Official Synonym Full Names    transthyretin
 NCBI Official Symbol    TTR [Similar Products]
 NCBI Official Synonym Symbols   
CTS; CTS1; PALB; TBPA; HEL111; HsT2651
[Similar Products]
 NCBI Protein Information    transthyretin; ATTR; carpal tunnel syndrome 1; epididymis luminal protein 111; prealbumin, amyloidosis type I; thyroxine-binding prealbumin
 UniProt Protein Name    Transthyretin
 UniProt Synonym Protein Names   
ATTR; Prealbumin; TBPA
 Protein Family    Transthyretin
 UniProt Gene Name    TTR [Similar Products]
 UniProt Synonym Gene Names    PALB [Similar Products]
 UniProt Entry Name    TTHY_HUMAN
Section Bar
 NCBI Summary for TTR    This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
Section Bar
 UniProt Comments for TTR    TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: extracellular space; protein complex; cytoplasm; extracellular region

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; hormone activity

Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; transport; retinol metabolic process; retinoid metabolic process

Disease: Hyperthyroxinemia, Dystransthyretinemic; Carpal Tunnel Syndrome; Amyloidosis, Hereditary, Transthyretin-related
Table BarTOPTable Bar
 Research Articles on TTR    1. Transthyretin, one of the major plasma proteins, has a number of posttranslational modifications and mutations, some of which are associated with the development of severe diseases, for instance, familial amyloid neuropathy and Alzheimer's disease
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TTR antibodyPathways associated with anti-TTR antibody
 Reference Product  PubMed Publications
 RBP4 antibody  >34 publications with TTR and RBP4
 SERPINA7 antibody  >30 publications with TTR and SERPINA7
 APP antibody  >12 publications with TTR and APP
 APOA1 antibody  >8 publications with TTR and APOA1
 APCS antibody  >2 publications with TTR and APCS
 FOXA3 antibody  >2 publications with TTR and FOXA3
 CST3 antibody  >1 publications with TTR and CST3
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Non-integrin Membrane-ECM Interactions Pathway antibodies  Non-integrin Membrane-ECM Interactions Pathway Diagram
 Retinoid Cycle Disease Events Pathway antibodies  Retinoid Cycle Disease Events Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
Diseases associated with anti-TTR antibodyOrgans/Tissues associated with anti-TTR antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >659 publications with TTR and Nervous System Diseases
 Amyloidosis, Familial Antibodies  >597 publications with TTR and Amyloidosis, Familial
 Amyloid Neuropathies, Familial Antibodies  >414 publications with TTR and Amyloid Neuropathies, Familial
 Cardiovascular Diseases Antibodies  >235 publications with TTR and Cardiovascular Diseases
 Heart Diseases Antibodies  >200 publications with TTR and Heart Diseases
 Brain Diseases Antibodies  >149 publications with TTR and Brain Diseases
 Liver Diseases Antibodies  >138 publications with TTR and Liver Diseases
 Liver Neoplasms Antibodies  >76 publications with TTR and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >73 publications with TTR and Carcinoma, Hepatocellular
 Inflammation Antibodies  >73 publications with TTR and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >496 publications with TTR and Liver
 Heart Antibodies  >250 publications with TTR and Heart
 Brain Antibodies  >247 publications with TTR and Brain
 Muscle Antibodies  >124 publications with TTR and Muscle
 Kidney Antibodies  >118 publications with TTR and Kidney
 Eye Antibodies  >96 publications with TTR and Eye
 Lung Antibodies  >59 publications with TTR and Lung
 Skin Antibodies  >50 publications with TTR and Skin
 Embryonic Tissue Antibodies  >33 publications with TTR and Embryonic Tissue
 Pancreas Antibodies  >31 publications with TTR and Pancreas
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions