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anti-PSEN1 antibody :: Rabbit anti-Mouse, Rat PRESENILIN-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS222948
Unit / Price
0.1 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRESENILIN-1 (PSEN1), Polyclonal Antibody

 Also Known As   

RABBIT ANTI PRESENILIN-1

 Product Gene Name   

anti-PSEN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104311
 3D Structure    ModBase 3D Structure for P49768
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat
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 Specificity    This item recognises human Presenilin-1, a 52.7 kDa membrane protein expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes.

Presenilin-1 was originally identified as a marker of susceptibility for familial early onset Alzheimer's disease type 3 (AD3). Presenilin-1, along with PEN2, Nicastrin and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. Cleavage of these proteins is a key step in signalling from several cell-surface receptors and is believed to be required for the generation of neurotoxic amyloid peptides that are central in the development of Alzheimer's disease.

Research indicates that at least 6 isoforms of Presenilin-1 exist.

This item is specific for Presenilin-1 and shows no cross reactivity with Presenilin-2.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.02% Sodium Azide (NaN3)
 Immunogen    A 23 amino acid peptide from near the carboxy terminus of human presenilin-1.
Histology Positive Control Tissue
 Antiserum Preparation    Antiserum to human Presenilin-1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-PSEN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PSEN1 antibody

   MBS222948 recognises human Presenilin-1, a 52.7 kDa membrane protein expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes. Presenilin-1 was originally identified as a marker of susceptibility for familial early onset Alzheimer's disease type 3 (AD3). Presenilin-1, along with PEN2, Nicastrin and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. Cleavage of these proteins is a key step in signalling from several cell-surface receptors and is believed to be required for the generation of neurotoxic amyloid peptides that are central in the development of Alzheimer's disease. Research indicates that at least 6 isoforms of Presenilin-1 exist. MBS222948 is specific for Presenilin-1 and shows no cross reactivity with Presenilin-2.
 Applications Tested/Suitable for anti-PSEN1 antibody   

Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-PSEN1 antibody    Western Blot: This item detects a band of approximately 44kDa in human brain cell lysates.
Immunohistology - Paraffin: Maximum Dilution: 2.5ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1.0ug/ml
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 Testing Data #1 of anti-PSEN1 antibody    Western blot analysis of human brain lysate with Rabbit anti Human presenilin-1 (MBS222948) at 0.5(A), 1(B) and 2(C) ug/ml
anti-PSEN1 antibody Testing Data #1 image
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 Testing Data #2 of anti-PSEN1 antibody    Formalin fixed, paraffin embedded human brain with Rabbit anti Human presenilin-1 (MBS222948) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
anti-PSEN1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for PSEN1. It may not necessarily be applicable to this product.
 NCBI GI #    4506163
 NCBI GeneID    5663
 NCBI Accession #    NP_000012.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000021.3 [Other Products]
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 UniProt Primary Accession #    P49768 [Other Products]
 UniProt Secondary Accession #    O95465; Q14762; Q15719; Q15720; Q96P33; Q9UIF0; B2R6D3 [Other Products]
 UniProt Related Accession #    P49768 [Other Products]
 Molecular Weight    48,997 Da [Similar Products]
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 NCBI Official Full Name    presenilin-1 isoform I-467
 NCBI Official Synonym Full Names    presenilin 1
 NCBI Official Symbol    PSEN1 [Similar Products]
 NCBI Official Synonym Symbols   
AD3; FAD; PS1; PS-1; S182
[Similar Products]
 NCBI Protein Information    presenilin-1
 UniProt Protein Name    Presenilin-1
 UniProt Synonym Protein Names   
Protein S182Cleaved into the following 3 chains:Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12; PS1-CTF12
 Protein Family    Presenilin
 UniProt Gene Name    PSEN1 [Similar Products]
 UniProt Synonym Gene Names    AD3; PS1; PSNL1; PS-1; PS1-CTF12 [Similar Products]
 UniProt Entry Name    PSN1_HUMAN
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 NCBI Summary for PSEN1    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
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 UniProt Comments for PSEN1    PSEN1: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Regulates epithelial- cadherin function. Five alternative splice isoforms have been identified.

Protein type: Membrane protein, integral; Cell surface; Membrane protein, multi-pass; Protease; Mitochondrial; EC 3.4.23.-

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: Golgi apparatus; nuclear outer membrane; centrosome; cell surface; smooth endoplasmic reticulum; mitochondrion; lysosomal membrane; integral to plasma membrane; integral to membrane; lipid raft; ciliary rootlet; kinetochore; membrane; cell soma; perinuclear region of cytoplasm; apical plasma membrane; mitochondrial inner membrane; cytoplasmic vesicle; dendritic shaft; neuromuscular junction; endoplasmic reticulum membrane; nuclear membrane; rough endoplasmic reticulum; endoplasmic reticulum; cell cortex; Z disc; Golgi membrane; growth cone; axon

Molecular Function: protein binding; cadherin binding; calcium channel activity; endopeptidase activity; beta-catenin binding; aspartic-type endopeptidase activity; PDZ domain binding

Biological Process: positive regulation of catalytic activity; extracellular matrix organization and biogenesis; activation of MAPKK activity; positive regulation of apoptosis; beta-amyloid formation; regulation of synaptic plasticity; positive regulation of coagulation; Wnt receptor signaling pathway through beta-catenin; choline transport; T cell receptor signaling pathway; post-embryonic development; mitochondrial transport; T cell activation during immune response; extracellular matrix disassembly; positive regulation of MAP kinase activity; cell-cell adhesion; epithelial cell proliferation; negative regulation of axonogenesis; negative regulation of neuron apoptosis; autophagic vacuole formation; embryonic limb morphogenesis; somitogenesis; skin morphogenesis; regulation of phosphorylation; Notch receptor processing; negative regulation of ubiquitin-protein ligase activity; neuron development; Cajal-Retzius cell differentiation; hemopoietic progenitor cell differentiation; response to oxidative stress; negative regulation of apoptosis; regulation of synaptic transmission, glutamatergic; protein maturation; neuron migration; protein amino acid glycosylation; myeloid dendritic cell differentiation; cell fate specification; negative regulation of transcription from RNA polymerase II promoter; amyloid precursor protein catabolic process; protein transport; beta-amyloid metabolic process; regulation of resting membrane potential; brain morphogenesis; heart looping; positive regulation of receptor recycling; dorsoventral neural tube patterning; blood vessel development; Notch signaling pathway; L-glutamate transport; thymus development; membrane protein ectodomain proteolysis; memory; negative regulation of epidermal growth factor receptor activity; smooth endoplasmic reticulum calcium ion homeostasis; neuron apoptosis; endoplasmic reticulum calcium ion homeostasis; cerebral cortex cell migration; skeletal morphogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of protein binding; protein processing; synaptic vesicle targeting; response to DNA damage stimulus

Disease: Pick Disease Of Brain; Alzheimer Disease 3; Frontotemporal Dementia; Acne Inversa, Familial, 3; Cardiomyopathy, Dilated, 1u
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 Research Articles on PSEN1    1. PSEN1 is commonly associated with early-onset Alzheimer's disease and 2 novel and likely pathogenic mutations detected in this gene (p.L166V and p.S230R).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PSEN1 antibodyPathways associated with anti-PSEN1 antibody
 Reference Product  PubMed Publications
 APP antibody  >667 publications with PSEN1 and APP
 CTNNB1 antibody  >63 publications with PSEN1 and CTNNB1
 PSENEN antibody  >52 publications with PSEN1 and PSENEN
 NOTCH1 antibody  >43 publications with PSEN1 and NOTCH1
 APH1A antibody  >37 publications with PSEN1 and APH1A
 NCSTN antibody  >14 publications with PSEN1 and NCSTN
 GSK3B antibody  >4 publications with PSEN1 and GSK3B
 UBQLN1 antibody  >3 publications with PSEN1 and UBQLN1
 MTCH1 antibody  >2 publications with PSEN1 and MTCH1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with anti-PSEN1 antibodyOrgans/Tissues associated with anti-PSEN1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1624 publications with PSEN1 and Nervous System Diseases
 Alzheimer Disease Antibodies  >1614 publications with PSEN1 and Alzheimer Disease
 Brain Diseases Antibodies  >1601 publications with PSEN1 and Brain Diseases
 Disease Models, Animal Antibodies  >336 publications with PSEN1 and Disease Models, Animal
 Memory Disorders Antibodies  >124 publications with PSEN1 and Memory Disorders
 Cognition Disorders Antibodies  >83 publications with PSEN1 and Cognition Disorders
 Learning Disorders Antibodies  >73 publications with PSEN1 and Learning Disorders
 Frontotemporal Dementia Antibodies  >67 publications with PSEN1 and Frontotemporal Dementia
 Nerve Degeneration Antibodies  >52 publications with PSEN1 and Nerve Degeneration
 Cardiovascular Diseases Antibodies  >50 publications with PSEN1 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >965 publications with PSEN1 and Brain
 Blood Antibodies  >156 publications with PSEN1 and Blood
 Vascular Antibodies  >60 publications with PSEN1 and Vascular
 Kidney Antibodies  >55 publications with PSEN1 and Kidney
 Embryonic Tissue Antibodies  >28 publications with PSEN1 and Embryonic Tissue
 Skin Antibodies  >23 publications with PSEN1 and Skin
 Spinal Cord Antibodies  >20 publications with PSEN1 and Spinal Cord
 Muscle Antibodies  >20 publications with PSEN1 and Muscle
 Liver Antibodies  >15 publications with PSEN1 and Liver
 Bone Antibodies  >14 publications with PSEN1 and Bone
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