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anti-PREX2 antibody :: Rabbit anti-Human, Mouse PREX2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7050465
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PREX2, Polyclonal Antibody

★Popular Item★
 Also Known As   

PREX2 Antibody

 Product Synonym Names    Phosphatidylinositol 3; 4; 5-trisphosphate-dependent Rac exchanger 2 proteinP-Rex2PtdIns(3; 4; 5)-dependent Rac exchanger 2; DEP domain-containing protein 2; PREX2; DEPDC2
 Product Gene Name   

anti-PREX2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AJ437636 mRNA
 3D Structure    ModBase 3D Structure for Q70Z35
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 2 protein (1417-1592AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PREX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PREX2 antibody

   Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3, 4, 5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
 Applications Tested/Suitable for anti-PREX2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-PREX2 antibody    WB: 1: 2000-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-PREX2 antibody    Western Blot
Positive WB detected in:Mouse brain tissue
All lanes: PREX2 antibody at 3.4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 183,172,113 kDa
Observed band size: 183,113 kDa

anti-PREX2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PREX2 antibody    Immunohistochemistry of paraffin-embedded human renal tissue using MBS7050465 at dilution of 1:100
anti-PREX2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PREX2 antibody    Immunofluorescent analysis of HepG2 cells using MBS7050465 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PREX2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PREX2. It may not necessarily be applicable to this product.
 NCBI GI #    47578115
 NCBI GeneID    80243
 NCBI Accession #    NP_079146.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_024870.3 [Other Products]
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 UniProt Primary Accession #    Q70Z35 [Other Products]
 UniProt Secondary Accession #    Q32KL0; Q32KL1; Q6R7Q3; Q6R7Q4; Q9H805; Q9H961; B4DFX0 [Other Products]
 UniProt Related Accession #    Q70Z35 [Other Products]
 Molecular Weight    112,404 Da
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 NCBI Official Full Name    phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform a
 NCBI Official Synonym Full Names    phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
 NCBI Official Symbol    PREX2 [Similar Products]
 NCBI Official Synonym Symbols   
DEP.2; DEPDC2; P-REX2; PPP1R129
[Similar Products]
 NCBI Protein Information    phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
 UniProt Protein Name    Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
 UniProt Synonym Protein Names   
DEP domain-containing protein 2
 Protein Family    Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
 UniProt Gene Name    PREX2 [Similar Products]
 UniProt Synonym Gene Names    DEPDC2; P-Rex2; PtdIns(3,4,5)-dependent Rac exchanger 2 [Similar Products]
 UniProt Entry Name    PREX2_HUMAN
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 NCBI Summary for PREX2    The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016]
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 UniProt Comments for PREX2    PREX2: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho; Phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 8q13.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: GTPase activator activity; Rac guanyl-nucleotide exchange factor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of protein kinase activity; negative regulation of TOR signaling pathway
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 Research Articles on PREX2    1. knockdown of PREX2a may effectively inhibit the malignant phenotype of glioma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PREX2 antibodyPathways associated with anti-PREX2 antibody
 Reference Product  PubMed Publications
 PTEN antibody  >15 publications with PREX2 and PTEN
 RAC1 antibody  >15 publications with PREX2 and RAC1
 MTOR antibody  >1 publications with PREX2 and MTOR
 Products by Pathway  Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
Diseases associated with anti-PREX2 antibodyOrgans/Tissues associated with anti-PREX2 antibody
 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >2 publications with PREX2 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with PREX2 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >2 publications with PREX2 and Disease Models, Animal
 Brain Diseases Antibodies  >1 publications with PREX2 and Brain Diseases
 Hepatitis Antibodies  >1 publications with PREX2 and Hepatitis
 Chromosome Breakage Antibodies  >1 publications with PREX2 and Chromosome Breakage
 Fibrosis Antibodies  >1 publications with PREX2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >2 publications with PREX2 and Adipose Tissue
 Vascular Antibodies  >2 publications with PREX2 and Vascular
 Brain Antibodies  >2 publications with PREX2 and Brain
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