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anti-PRG2 antibody :: Rabbit anti-Human, Mouse PRG2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS129091
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRG2, Polyclonal Antibody

★Popular Item★
 Also Known As   

PRG2 Polyclonal Antibody

 Product Synonym Names    MBP; BMPG; MBP1
 Product Gene Name   

anti-PRG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605601
 3D Structure    ModBase 3D Structure for P13727
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human PRG2
 Calculated Molecular Weight    25kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-PRG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PRG2 antibody

   The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-PRG2 antibody    Polyclonal
 Applications Tested/Suitable for anti-PRG2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PRG2 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-PRG2 antibody    Western blot analysis of extracts of various cell lines, using PRG2 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-PRG2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PRG2. It may not necessarily be applicable to this product.
 NCBI GI #    281185479
 NCBI GeneID    5553
 NCBI Accession #    P13727.2 [Other Products]
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 UniProt Primary Accession #    P13727 [Other Products]
 UniProt Secondary Accession #    P81448; Q14227; Q6ICT2; A6XMW0; B2R5I1 [Other Products]
 UniProt Related Accession #    P13727 [Other Products]
 Molecular Weight    25kDa
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 NCBI Official Full Name    Bone marrow proteoglycan
 NCBI Official Synonym Full Names    proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
 NCBI Official Symbol    PRG2 [Similar Products]
 NCBI Official Synonym Symbols   
MBP; BMPG; MBP1
[Similar Products]
 NCBI Protein Information    bone marrow proteoglycan; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein
 UniProt Protein Name    Bone marrow proteoglycan
 UniProt Synonym Protein Names   
Proteoglycan 2Eosinophil granule major basic protein; EMBP; MBPAlternative name(s):Pregnancy-associated major basic protein
 Protein Family    Bone marrow proteoglycan
 UniProt Gene Name    PRG2 [Similar Products]
 UniProt Synonym Gene Names    MBP; BMPG; EMBP; MBP [Similar Products]
 UniProt Entry Name    PRG2_HUMAN
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 NCBI Summary for PRG2    The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
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 UniProt Comments for PRG2    PRG2: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Protein type: Vesicle; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: transport vesicle; extracellular region

Molecular Function: heparin binding; carbohydrate binding

Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; defense response to bacterium; immune response; defense response to nematode
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 Research Articles on PRG2    1. mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRG2 antibodyPathways associated with anti-PRG2 antibody
 Reference Product  PubMed Publications
 EPX antibody  >2 publications with PRG2 and EPX
 AGT antibody  >2 publications with PRG2 and AGT
 PAPPA antibody  >1 publications with PRG2 and PAPPA
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
Diseases associated with anti-PRG2 antibodyOrgans/Tissues associated with anti-PRG2 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4 publications with PRG2 and Immune System Diseases
 Hypertension Antibodies  >3 publications with PRG2 and Hypertension
 Inflammation Antibodies  >3 publications with PRG2 and Inflammation
 Carcinoma Antibodies  >2 publications with PRG2 and Carcinoma
 Pancreatic Neoplasms Antibodies  >2 publications with PRG2 and Pancreatic Neoplasms
 Lung Diseases Antibodies  >1 publications with PRG2 and Lung Diseases
 Lymphoma Antibodies  >1 publications with PRG2 and Lymphoma
 Ovarian Neoplasms Antibodies  >1 publications with PRG2 and Ovarian Neoplasms
 Kidney Diseases Antibodies  >1 publications with PRG2 and Kidney Diseases
 Lung Neoplasms Antibodies  >1 publications with PRG2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with PRG2 and Blood
 Bone Marrow Antibodies  >5 publications with PRG2 and Bone Marrow
 Heart Antibodies  >1 publications with PRG2 and Heart
 Vascular Antibodies  >1 publications with PRG2 and Vascular
 Intestine Antibodies  >1 publications with PRG2 and Intestine
 Placenta Antibodies  >1 publications with PRG2 and Placenta
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