NP_001308911.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,067 Da
NCBI Official Full Name
cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a
NCBI Official Synonym Full Names
protein kinase cAMP-dependent type II regulatory subunit alpha
NCBI Official Synonym Symbols
NCBI Protein Information
cAMP-dependent protein kinase type II-alpha regulatory subunit
UniProt Protein Name
cAMP-dependent protein kinase type II-alpha regulatory subunit
UniProt Synonym Gene Names
NCBI Summary for PRKAR2A
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
UniProt Comments for PRKAR2A
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Research Articles on PRKAR2A
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Products associated with anti-PRKAR2A antibody
Pathways associated with anti-PRKAR2A antibody
Diseases associated with anti-PRKAR2A antibody
Disease Name |
Pubmed Publications |
Disease Models, Animal Antibodies |
>6 publications with PRKAR2A and Disease Models, Animal |
Neoplasms, Experimental Antibodies |
>2 publications with PRKAR2A and Neoplasms, Experimental |
Liver Neoplasms Antibodies |
>2 publications with PRKAR2A and Liver Neoplasms |
Liver Diseases Antibodies |
>2 publications with PRKAR2A and Liver Diseases |
Cell Transformation, Neoplastic Antibodies |
>2 publications with PRKAR2A and Cell Transformation, Neoplastic |
Infertility, Male Antibodies |
>1 publications with PRKAR2A and Infertility, Male |
Infertility, Female Antibodies |
>1 publications with PRKAR2A and Infertility, Female |
Chromosome Breakage Antibodies |
>1 publications with PRKAR2A and Chromosome Breakage |
Asthenozoospermia Antibodies |
>1 publications with PRKAR2A and Asthenozoospermia |
Carcinoma, Hepatocellular Antibodies |
>1 publications with PRKAR2A and Carcinoma, Hepatocellular |
Organs/Tissues associated with anti-PRKAR2A antibody
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