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anti-PRKCA antibody :: Rabbit PRKCA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2523382
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRKCA, Polyclonal Antibody

★Popular Item★
 Also Known As   

PRKCA Polyclonal Antibody

 Product Synonym Names    AAG6; PKCA; PRKACA; PKC-alpha
 Product Gene Name   

anti-PRKCA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176960
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.4mg/mL (lot specific)
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 Immunogen    Recombinant protein of human PRKCA
 Calculated Molecular Weight: 77kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PRKCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PRKCA antibody

   Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
 Product Categories/Family for anti-PRKCA antibody    Cancer; Epigenetics
 Applications Tested/Suitable for anti-PRKCA antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PRKCA antibody    WB: 1:200-1:1000
IHC: 1:25-1:100
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 Western Blot (WB) of anti-PRKCA antibody    Western Blot analysis of Jurkat and 293T cell using PRKCA Polyclonal Antibody at dilution of 1:100
anti-PRKCA antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PRKCA antibody    Immunohistochemistry of paraffin-embedded Human liver cancer using PRKCA Polyclonal Antibody at dilution of 1:10
anti-PRKCA antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PRKCA antibody    Immunohistochemistry of paraffin-embedded Human lung cancer using PRKCA Polyclonal Antibody at dilution of 1:10
anti-PRKCA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PRKCA. It may not necessarily be applicable to this product.
 NCBI GI #    31544941
 NCBI GeneID    5578
 NCBI Accession #    AAH53321.1 [Other Products]
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 UniProt Secondary Accession #    Q15137; Q32M72; Q96RE4; B5BU22 [Other Products]
 UniProt Related Accession #    P17252 [Other Products]
 Molecular Weight    76,750 Da
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 NCBI Official Full Name    PRKCA protein, partial
 NCBI Official Synonym Full Names    protein kinase C, alpha
 NCBI Official Symbol    PRKCA [Similar Products]
 NCBI Official Synonym Symbols   
AAG6; PKCA; PRKACA; PKC-alpha
[Similar Products]
 NCBI Protein Information    protein kinase C alpha type; PKC-A; aging-associated gene 6
 UniProt Protein Name    Protein kinase C alpha type
 Protein Family    Protein kinase
 UniProt Gene Name    PRKCA [Similar Products]
 UniProt Synonym Gene Names    PKCA; PRKACA; PKC-A; PKC-alpha [Similar Products]
 UniProt Entry Name    KPCA_HUMAN
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 NCBI Summary for PRKCA    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRKCA    PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators.

Protein type: Oncoprotein; EC 2.7.11.13; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; PKC family; Alpha subfamily

Chromosomal Location of Human Ortholog: 17q22-q23.2

Cellular Component: nucleoplasm; photoreceptor outer segment; cell soma; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; apical part of cell; mitochondrial membrane; dendrite; cytoplasm; plasma membrane; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; enzyme binding; protein kinase C activity; zinc ion binding; calcium-dependent protein kinase C activity; ATP binding; protein kinase activity

Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; nerve growth factor receptor signaling pathway; regulation of muscle contraction; positive regulation of lipopolysaccharide-mediated signaling pathway; mitotic nuclear envelope disassembly; negative regulation of insulin receptor signaling pathway; positive regulation of mitotic cell cycle; signal transduction; protein amino acid phosphorylation; induction of positive chemotaxis; synaptic transmission; negative regulation of cell proliferation; chondrocyte differentiation; angiogenesis; positive regulation of macrophage differentiation; cell adhesion; regulation of peptidyl-tyrosine phosphorylation; regulation of the force of heart contraction; inactivation of MAPK activity; epidermal growth factor receptor signaling pathway; neutrophil chemotaxis; platelet activation; fibroblast growth factor receptor signaling pathway; positive regulation of blood vessel endothelial cell migration; adenylate cyclase activation; negative regulation of adenylate cyclase activity; cellular calcium ion homeostasis; rhodopsin mediated signaling; positive regulation of angiogenesis; negative regulation of glucose import; regulation of rhodopsin mediated signaling; phospholipase C activation; energy reserve metabolic process; innate immune response; gene expression; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; vascular endothelial growth factor receptor signaling pathway; blood coagulation; regulation of insulin secretion; positive regulation of inflammatory response; positive regulation of cell migration
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 Research Articles on PRKCA    1. CD44/selectin binding signals increased intercellular adhesion molecule 1 up-regulation on the endothelial cells (ECs)surface through a PKCalpha-p38-SP-1 pathway, which further enhances melanoma cell adhesion to ECs during metastasis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRKCA antibodyPathways associated with anti-PRKCA antibody
 Reference Product  PubMed Publications
 PLD1 antibody  >43 publications with PRKCA and PLD1
 MARCKS antibody  >35 publications with PRKCA and MARCKS
 SDC4 antibody  >25 publications with PRKCA and SDC4
 RAC1 antibody  >25 publications with PRKCA and RAC1
 PICK1 antibody  >24 publications with PRKCA and PICK1
 PLD2 antibody  >17 publications with PRKCA and PLD2
 RICTOR antibody  >6 publications with PRKCA and RICTOR
 RARA antibody  >1 publications with PRKCA and RARA
 GJA1 antibody  >1 publications with PRKCA and GJA1
 EZR antibody  >1 publications with PRKCA and EZR
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Acetylcholine Regulates Insulin Secretion Pathway antibodies  Acetylcholine Regulates Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
Diseases associated with anti-PRKCA antibodyOrgans/Tissues associated with anti-PRKCA antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >167 publications with PRKCA and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >159 publications with PRKCA and Disease Models, Animal
 Nervous System Diseases Antibodies  >128 publications with PRKCA and Nervous System Diseases
 Inflammation Antibodies  >126 publications with PRKCA and Inflammation
 Brain Diseases Antibodies  >113 publications with PRKCA and Brain Diseases
 Breast Neoplasms Antibodies  >104 publications with PRKCA and Breast Neoplasms
 Necrosis Antibodies  >90 publications with PRKCA and Necrosis
 Heart Diseases Antibodies  >88 publications with PRKCA and Heart Diseases
 Neoplasms, Experimental Antibodies  >76 publications with PRKCA and Neoplasms, Experimental
 Hypertension Antibodies  >71 publications with PRKCA and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >400 publications with PRKCA and Blood
 Muscle Antibodies  >397 publications with PRKCA and Muscle
 Brain Antibodies  >343 publications with PRKCA and Brain
 Heart Antibodies  >221 publications with PRKCA and Heart
 Lung Antibodies  >189 publications with PRKCA and Lung
 Kidney Antibodies  >177 publications with PRKCA and Kidney
 Liver Antibodies  >147 publications with PRKCA and Liver
 Eye Antibodies  >131 publications with PRKCA and Eye
 Skin Antibodies  >77 publications with PRKCA and Skin
 Intestine Antibodies  >65 publications with PRKCA and Intestine
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