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anti-PRKCI antibody :: Rabbit PRKCI Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS125450
Western Blot (WB)
Unit / Price
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRKCI, Polyclonal Antibody

 Also Known As   

PRKCI Polyclonal Antibody

 Product Synonym Names    PKCzeta/lambda: DXS1179E; MGC26534; PKCI; nPKC-iota
 Product Gene Name   

anti-PRKCI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600539
 3D Structure    ModBase 3D Structure for P41743
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human PRKCI
 Calculated Molecular Weight    68kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-PRKCI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PRKCI antibody

   This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
 Product Categories/Family for anti-PRKCI antibody    Polyclonal
 Applications Tested/Suitable for anti-PRKCI antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

 Application Notes for anti-PRKCI antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IP: 1:50 - 1:200
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 Western Blot (WB) of anti-PRKCI antibody    Western blot analysis of extracts of MCF-7 cells, using PRKCI antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-PRKCI antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PRKCI. It may not necessarily be applicable to this product.
 NCBI GI #    239938658
 NCBI GeneID    5584
 NCBI Accession #    P41743.2 [Other Products]
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 UniProt Primary Accession #    P41743 [Other Products]
 UniProt Secondary Accession #    Q8WW06; D3DNQ4 [Other Products]
 UniProt Related Accession #    P41743 [Other Products]
 Molecular Weight    596
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 NCBI Official Full Name    Protein kinase C iota type
 NCBI Official Synonym Full Names    protein kinase C, iota
 NCBI Official Symbol    PRKCI [Similar Products]
 NCBI Official Synonym Symbols   
PKCI; DXS1179E; nPKC-iota
[Similar Products]
 NCBI Protein Information    protein kinase C iota type; PRKC-lambda/iota; aPKC-lambda/iota; atypical protein kinase C-lambda/iota
 UniProt Protein Name    Protein kinase C iota type
 UniProt Synonym Protein Names   
Atypical protein kinase C-lambda/iota; PRKC-lambda/iota; aPKC-lambda/iota; nPKC-iota
 Protein Family    Protein kinase
 UniProt Gene Name    PRKCI [Similar Products]
 UniProt Synonym Gene Names    DXS1179E; PRKC-lambda/iota; aPKC-lambda/iota [Similar Products]
 UniProt Entry Name    KPCI_HUMAN
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 NCBI Summary for PRKCI    This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRKCI    PKCI: an AGC protein kinase of the PKC family. A calcium-independent, phospholipid-dependent atypical protein kinase C. Is not activated by phorbolesters or diaglycerol. May play role in the secretory response to nutrients. Involved in cell polarization processes and the formation of epithelial tight junctions. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets.

Protein type: Cell adhesion; Cell development/differentiation; Kinase, protein; EC 2.7.11.13; Motility/polarity/chemotaxis; Protein kinase, AGC; Oncoprotein; Tumor suppressor; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Iota subfamily

Chromosomal Location of Human Ortholog: 3q26.3

Cellular Component: Golgi membrane; microtubule cytoskeleton; intercellular bridge; tight junction; protein complex; cytoplasm; leading edge; apical plasma membrane; plasma membrane; nucleus; cytosol; endosome

Molecular Function: protein domain specific binding; protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; phospholipid binding; ATP binding; protein kinase activity

Biological Process: intercellular junction assembly and maintenance; secretion; cell migration; nerve growth factor receptor signaling pathway; establishment of apical/basal cell polarity; actin filament organization; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; establishment and/or maintenance of epithelial cell polarity; vesicle-mediated transport; positive regulation of glucose import; eye photoreceptor cell development; cellular response to insulin stimulus; Golgi vesicle budding; negative regulation of neuron apoptosis; protein targeting to membrane; negative regulation of apoptosis
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 Research Articles on PRKCI    1. PKCiota gene amplification is correlated with gender, subtype and distant metastasis in Chinese patients with non-small cell lung cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRKCI antibodyPathways associated with anti-PRKCI antibody
 Reference Product  PubMed Publications
 PARD3 antibody  >2 publications with PRKCI and PARD3
 CDC42 antibody  >1 publications with PRKCI and CDC42
 Products by Pathway  Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with anti-PRKCI antibodyOrgans/Tissues associated with anti-PRKCI antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >2 publications with PRKCI and Neoplasm Metastasis
 Inflammation Antibodies  >2 publications with PRKCI and Inflammation
 Esophageal Neoplasms Antibodies  >1 publications with PRKCI and Esophageal Neoplasms
 Hyperplasia Antibodies  >1 publications with PRKCI and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with PRKCI and Breast Neoplasms
 Heart Failure Antibodies  >1 publications with PRKCI and Heart Failure
 Kidney Diseases Antibodies  >1 publications with PRKCI and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with PRKCI and Blood
 Brain Antibodies  >4 publications with PRKCI and Brain
 Lung Antibodies  >3 publications with PRKCI and Lung
 Prostate Antibodies  >3 publications with PRKCI and Prostate
 Intestine Antibodies  >2 publications with PRKCI and Intestine
 Muscle Antibodies  >2 publications with PRKCI and Muscle
 Heart Antibodies  >1 publications with PRKCI and Heart
 Spinal Cord Antibodies  >1 publications with PRKCI and Spinal Cord
 Ovary Antibodies  >1 publications with PRKCI and Ovary
 Kidney Antibodies  >1 publications with PRKCI and Kidney
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