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anti-PRKD1 antibody :: Rabbit anti-Human, Mouse PRKD1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9404610
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRKD1, Polyclonal Antibody

★Popular Item★
 Also Known As   

PRKD1 Antibody

 Product Synonym Names    PKD; PKCM; PRKCM; PKC-MU
 Product Gene Name   

anti-PRKD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605435
 3D Structure    ModBase 3D Structure for Q15139
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    The antibody detects endogenous levels of total PRKD1 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    3.3 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthetic peptide corresponding to residues near the C terminal of human protein kinase D1
 Target Name    PRKD1
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-PRKD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PRKD1 antibody

   PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion.
 Product Categories/Family for anti-PRKD1 antibody    Total protein Ab
 Applications Tested/Suitable for anti-PRKD1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PRKD1 antibody    Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
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 Testing Data of anti-PRKD1 antibody    Gel: 6%SDS-PAGE Lysates (from left to right): 293T and NIH/3T3 cell Amount of lysate: 40ug per lane Primary antibody: 1/550 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds
anti-PRKD1 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-PRKD1 antibody    Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/40.
anti-PRKD1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PRKD1. It may not necessarily be applicable to this product.
 NCBI GI #    115529463
 NCBI GeneID    5587
 NCBI Accession #    NP_002733 [Other Products]
 NCBI GenBank Nucleotide #    NM_002742.2 [Other Products]
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 UniProt Primary Accession #    Q15139 [Other Products]
 UniProt Secondary Accession #    A6NL64; B2RAF6 [Other Products]
 UniProt Related Accession #    Q15139 [Other Products]
 Molecular Weight    102kd
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 NCBI Official Full Name    serine/threonine-protein kinase D1
 NCBI Official Synonym Full Names    protein kinase D1
 NCBI Official Symbol    PRKD1 [Similar Products]
 NCBI Official Synonym Symbols   
PKD; PKCM; PRKCM; PKC-MU
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase D1
 UniProt Protein Name    Serine/threonine-protein kinase D1
 UniProt Synonym Protein Names   
Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    PRKD1 [Similar Products]
 UniProt Synonym Gene Names    PKD; PKD1; PRKCM [Similar Products]
 UniProt Entry Name    KPCD1_HUMAN
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 NCBI Summary for PRKD1    PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]
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 UniProt Comments for PRKD1    PRKD1: a CAMK kinase of the PKD family. Cleavage by caspase-3 following DNA damage activates it and alters its subcellular localization. Sensitizes cells to apoptosis induced by genotoxic stress. Its cleavage is blocked in cells that over-express the anti-apoptotic Bcl-x(L) protein. Expression of a caspase-resistant mutant partially inhibits DNA damage-induced apoptosis. Its activation by TLR ligands is dependent on MyD88, IRAK4 and -1, but not TRAF6. Essential for MyD88-dependent proinflammatory immune responses. Activated by diacylglycerol and phorbol esters. Binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Colocalizes with F-actin at peripheral F-actin-rich structures in membrane ruffles at the edge of lamellipodia in cervical carcinoma cells. Substrates reportedly include critical regulatory proteins including CREB, SSH1L, CTNNB1, HDACs 5 and 7, PKD1, HPK1, MARK2, PIP5K2A, PPP1R14A

Protein type: Protein kinase, CAMK; Motility/polarity/chemotaxis; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Autophagy; CAMK group; PKD family

Chromosomal Location of Human Ortholog: 14q11

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; intercellular junction; cell cortex; trans-Golgi network; nucleus; cytosol

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; protein kinase C activity; metal ion binding; ATP binding

Biological Process: integrin-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; sphingolipid metabolic process; sphingolipid biosynthetic process; apoptosis; negative regulation of endocytosis; protein amino acid autophosphorylation; positive regulation of blood vessel endothelial cell migration; activation of CREB transcription factor; signal transduction; positive regulation of peptidyl-serine phosphorylation; Golgi vesicle transport; activation of NF-kappaB transcription factor; cell proliferation; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; peptidyl-serine phosphorylation; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; vascular endothelial growth factor receptor signaling pathway; inflammatory response; Golgi organization and biogenesis
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 Research Articles on PRKD1    1. a positive relationship between L1 and pPKD1 in both cultured cerebellar neurons and human cerebellar tissue, suggesting that L1 functions in the modulation of PKD1 phosphorylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRKD1 antibodyPathways associated with anti-PRKD1 antibody
 Reference Product  PubMed Publications
 PKD1 antibody  >3 publications with PRKD1 and PKD1
 JUN antibody  >1 publications with PRKD1 and JUN
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 IGF1 Pathway antibodies  IGF1 Pathway Diagram
 LPA Receptor Mediated Events Pathway antibodies  LPA Receptor Mediated Events Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
Diseases associated with anti-PRKD1 antibodyOrgans/Tissues associated with anti-PRKD1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with PRKD1 and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >5 publications with PRKD1 and Neurobehavioral Manifestations
 Adenocarcinoma Antibodies  >4 publications with PRKD1 and Adenocarcinoma
 Salivary Gland Neoplasms Antibodies  >3 publications with PRKD1 and Salivary Gland Neoplasms
 Weight Gain Antibodies  >2 publications with PRKD1 and Weight Gain
 Neoplasm Invasiveness Antibodies  >1 publications with PRKD1 and Neoplasm Invasiveness
 Kidney Diseases Antibodies  >1 publications with PRKD1 and Kidney Diseases
 Lung Neoplasms Antibodies  >1 publications with PRKD1 and Lung Neoplasms
 Death Antibodies  >1 publications with PRKD1 and Death
 Breast Neoplasms Antibodies  >1 publications with PRKD1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with PRKD1 and Brain
 Heart Antibodies  >3 publications with PRKD1 and Heart
 Lung Antibodies  >2 publications with PRKD1 and Lung
 Kidney Antibodies  >2 publications with PRKD1 and Kidney
 Eye Antibodies  >1 publications with PRKD1 and Eye
 Ear Antibodies  >1 publications with PRKD1 and Ear
 Liver Antibodies  >1 publications with PRKD1 and Liver
 Stomach Antibodies  >1 publications with PRKD1 and Stomach
 Bone Antibodies  >1 publications with PRKD1 and Bone
 Pancreas Antibodies  >1 publications with PRKD1 and Pancreas
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