CAG38556.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,635 Da
NCBI Official Full Name
PRKRA
NCBI Official Synonym Full Names
protein kinase, interferon-inducible double stranded RNA dependent activator
NCBI Protein Information
interferon-inducible double-stranded RNA-dependent protein kinase activator A; PKR-associated protein X; PKR-associating protein X; interferon-inducible double stranded RNA-dependent protein kinase activator A; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator; protein kinase, interferon-inducible double-stranded RNA-dependent activator
UniProt Protein Name
Interferon-inducible double-stranded RNA-dependent protein kinase activator A
UniProt Synonym Protein Names
PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator
UniProt Synonym Gene Names
UniProt Entry Name
PRKRA_HUMAN
NCBI Summary for PRKRA
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
UniProt Comments for PRKRA
PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported.
Protein type: RNA-binding; RNA processing; Activator
Chromosomal Location of Human Ortholog: 2q31.2
Cellular Component: nucleoplasm; membrane; perinuclear region of cytoplasm; cytoplasm; cytosol
Molecular Function: protein binding; protein homodimerization activity; enzyme activator activity
Biological Process: positive regulation of catalytic activity; negative regulation of cell proliferation; skeletal morphogenesis; response to virus; outer ear morphogenesis; immune response; gene expression; middle ear morphogenesis; protein amino acid phosphorylation; RNA interference, production of siRNA
Disease: Dystonia 16
Research Articles on PRKRA
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Products associated with anti-PRKRA antibody
Pathways associated with anti-PRKRA antibody
Diseases associated with anti-PRKRA antibody
Organs/Tissues associated with anti-PRKRA antibody
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