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anti-PRSS2 antibody :: Rabbit anti-Human, Mouse PRSS2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7048947
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRSS2, Polyclonal Antibody

★Popular Item★
 Also Known As   

PRSS2 Antibody

 Product Synonym Names    Trypsin-2; Anionic trypsinogen; Serine protease 2; Trypsin II; PRSS2; TRY2; TRYP2
 Product Gene Name   

anti-PRSS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M27602 mRNA
 3D Structure    ModBase 3D Structure for P07478
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Trypsin-2 protein (24-247AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PRSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PRSS2 antibody

   In the ileum, may be involved in defensin processing, including DEFA5.
 Applications Tested/Suitable for anti-PRSS2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PRSS2 antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
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 Western Blot (WB) of anti-PRSS2 antibody    Western Blot
Positive WB detected in:Mouse heart tissue,Mouse liver tissue,Mouse brain tissue,Mouse kidney tissue
All lanes: PRSS2 antibody at 3ug/ml
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 27 kDa
Observed band size: 27 kDa

anti-PRSS2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PRSS2 antibody    Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7048947 at dilution of 1:100
anti-PRSS2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PRSS2. It may not necessarily be applicable to this product.
 NCBI GI #    4506147
 NCBI GeneID    5645
 NCBI Accession #    NP_002761.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002770.3 [Other Products]
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 UniProt Primary Accession #    P07478 [Other Products]
 UniProt Related Accession #    P07478 [Other Products]
 Molecular Weight    26,488 Da
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 NCBI Official Full Name    trypsin-2 isoform 2 preproprotein
 NCBI Official Synonym Full Names    protease, serine 2
 NCBI Official Symbol    PRSS2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    trypsin-2
 UniProt Protein Name    Trypsin-2
 UniProt Synonym Protein Names   
Anionic trypsinogen; Serine protease 2; Trypsin II
 Protein Family    Trypsin
 UniProt Gene Name    PRSS2 [Similar Products]
 UniProt Synonym Gene Names    TRY2; TRYP2 [Similar Products]
 UniProt Entry Name    TRY2_HUMAN
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 NCBI Summary for PRSS2    This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
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 UniProt Comments for PRSS2    trypsin 2: In the ileum, may be involved in defensin processing, including DEFA5. Belongs to the peptidase S1 family.

Protein type: Calcium-binding; Cell adhesion; EC; Extracellular matrix; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: calcium ion binding; protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: collagen catabolic process; digestion; extracellular matrix disassembly; positive regulation of cell adhesion; positive regulation of cell growth; proteolysis

Disease: Pancreatitis, Hereditary
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 Research Articles on PRSS2    1. evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PRSS2 antibodyDiseases associated with anti-PRSS2 antibody
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Antimicrobial Peptides Pathway antibodies  Antimicrobial Peptides Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Disease Name  Pubmed Publications
 Pancreatitis, Chronic Antibodies  >51 publications with PRSS2 and Pancreatitis, Chronic
 Fibrosis Antibodies  >27 publications with PRSS2 and Fibrosis
 Pancreatic Neoplasms Antibodies  >14 publications with PRSS2 and Pancreatic Neoplasms
 Adenocarcinoma Antibodies  >10 publications with PRSS2 and Adenocarcinoma
 Inflammation Antibodies  >8 publications with PRSS2 and Inflammation
 Lung Diseases Antibodies  >7 publications with PRSS2 and Lung Diseases
 Lung Injury Antibodies  >2 publications with PRSS2 and Lung Injury
 Liver Neoplasms Antibodies  >2 publications with PRSS2 and Liver Neoplasms
 Weight Gain Antibodies  >1 publications with PRSS2 and Weight Gain
 Kidney Diseases Antibodies  >1 publications with PRSS2 and Kidney Diseases
Organs/Tissues associated with anti-PRSS2 antibody
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >37 publications with PRSS2 and Pancreas
 Intestine Antibodies  >4 publications with PRSS2 and Intestine
 Liver Antibodies  >4 publications with PRSS2 and Liver
 Lung Antibodies  >2 publications with PRSS2 and Lung
 Testis Antibodies  >1 publications with PRSS2 and Testis
 Prostate Antibodies  >1 publications with PRSS2 and Prostate
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