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anti-DLG4 antibody :: Rabbit anti-Rat PSD-95 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS502106
Testing Data
Unit / Price
0.1 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSD-95 (DLG4), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-PSD-95

 Product Gene Name   

anti-DLG4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_005109.3 (56369703..56400662). Location: 10q24
 3D Structure    ModBase 3D Structure for P31016
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat
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 Purity/Purification    Affinity Purified (Specific for ~95k PSD-95 protein.)
 Form/Format    100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
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 Antigen    Peptide corresponding to amino acid residues from the N-terminal region of rat PSD-95, conjugated to keyhole limpet hemocyanin (KLH).
 Immunogen Information    Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
 Immunogen Species    Rat
 Reactivity Assumed Based on 100% Sequence Homology    Bovine, human, mouse, non-human primates and zebra fish
 Species Reactivity Note    The antibody has been directly tested for reactivity in Western blots in rat and mouse tissues. It is anticipated that the antibody will also work with bovine, human, non-human primates and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
 Biological Significance    PSD-95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses (Kim and Sheng, 2004). Recent work suggests that interaction of the NMDAR with PSD-95 via these PDZ domains can be regulated by phosphorylation (Chung et al., 2004).
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 Preparation and Storage    Store at -20 degree C; stable for at least one year.
 Other Notes    Small volumes of anti-DLG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DLG4 antibody

   Affinity purified rabbit polyclonal antibody
 Applications Tested/Suitable for anti-DLG4 antibody   

Western Blot (WB)

 Application Notes for anti-DLG4 antibody    Quality Control: Western blots performed on each lot.
WB: 1:1000
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 Testing Data of anti-DLG4 antibody    anti-DLG4 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for DLG4. It may not necessarily be applicable to this product.
 NCBI GI #    9665227
 NCBI GeneID    29495
 NCBI Accession #    NP_062567.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019621.1 [Other Products]
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 UniProt Primary Accession #    P31016 [Other Products]
 UniProt Secondary Accession #    P97631 [Other Products]
 UniProt Related Accession #    P31016 [Other Products]
 Molecular Weight    95
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 NCBI Official Full Name    disks large homolog 4
 NCBI Official Synonym Full Names    discs, large homolog 4 (Drosophila)
 NCBI Official Symbol    Dlg4 [Similar Products]
 NCBI Official Synonym Symbols   
Dlgh4; PSD95; Sap90
[Similar Products]
 NCBI Protein Information    disks large homolog 4; PSD-95; SAP-90; discs large homolog 4; synapse-associated protein 90; postsynaptic density protein 95; synapse-associated protein SAP90
 UniProt Protein Name    Disks large homolog 4
 UniProt Synonym Protein Names   
Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90
 Protein Family    Disks large
 UniProt Gene Name    Dlg4 [Similar Products]
 UniProt Synonym Gene Names    Dlgh4; Psd95; PSD-95; SAP-90; SAP90 [Similar Products]
 UniProt Entry Name    DLG4_RAT
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 NCBI Summary for DLG4    a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway [RGD, Feb 2006]
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 UniProt Comments for DLG4    Function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Ref.17 Ref.19 Ref.27

Subunit structure: Interacts through its PDZ domains with ANO2 and NETO1. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ASIC3, certain splice forms of GRIN1, KCND2, CXADR, SYNGAP1, KCNA1, KCNA2, KCNA3, KCNA4, ERBB4, LRRC4; LRRC4B and SEMA4C. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. Interacts through its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN, SIPA1L1 and KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with ADR1B, ANKS1B and PRR7. May interact with HTR2A. Interacts with ADAM22, KLHL17 and LGI1. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4, but not with LRFN3 nor LRFN5. Interacts (via N-terminus tandem pair of PDZ domains) with GPER1 (via C-terminus tail motif); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner. Interacts (via N-terminus tandem pair of PDZ domains) with NOS1 (via N-terminus domain). Interacts with SHANK3.

Subcellular location: Cell membrane; Peripheral membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell junction › synapse. Note: High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Ref.6 Ref.7 Ref.14

Tissue specificity: Detected in brain (at protein level). Brain. Highest levels of isoform 2 in cerebellum, cortex, hippocampus, and corpus striatum. Ref.14 Ref.16

Domain: The PDZ domain 3 mediates interaction with ADR1B

By similarity.The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density

By similarity.

Post-translational modification: Palmitoylation of isoform 1 is required for targeting to postsynaptic density. Ref.12

Sequence similarities: Belongs to the MAGUK family.Contains 1 guanylate kinase-like domain.Contains 3 PDZ (DHR) domains.Contains 1 SH3 domain.
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Product References and Citations for anti-DLG4 antibody

   • Chung HJ, Huang YH, Lau LF, Huganir RL (2004) Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J Neurosci 24:10248-10259.
• Kim EJ, Sheng M (2004) PDZ domain proteins of synapses. Nat Rev Neurosci 5:771-781.
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 Research Articles on DLG4    1. Iodine deficiency and propylthiouracil treatment reduce synaptotagmin-1 and PSD-95 in the rat hippocampus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DLG4 antibodyDiseases associated with anti-DLG4 antibody
 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >31 publications with DLG4 and Nervous System Diseases
 Brain Diseases Antibodies  >28 publications with DLG4 and Brain Diseases
 Death Antibodies  >9 publications with DLG4 and Death
 Movement Disorders Antibodies  >6 publications with DLG4 and Movement Disorders
 Disease Models, Animal Antibodies  >6 publications with DLG4 and Disease Models, Animal
 Cognition Disorders Antibodies  >5 publications with DLG4 and Cognition Disorders
 Child Development Disorders, Pervasive Antibodies  >5 publications with DLG4 and Child Development Disorders, Pervasive
 Learning Disorders Antibodies  >4 publications with DLG4 and Learning Disorders
 Pain Antibodies  >4 publications with DLG4 and Pain
 Neurotoxicity Syndromes Antibodies  >2 publications with DLG4 and Neurotoxicity Syndromes
Organs/Tissues associated with anti-DLG4 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >83 publications with DLG4 and Brain
 Eye Antibodies  >4 publications with DLG4 and Eye
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