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anti-PSEN2 antibody :: Rabbit anti-Human, Rat PSEN2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052325
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSEN2, Polyclonal Antibody

★Popular Item★
 Also Known As   

PSEN2 Antibody

 Product Synonym Names    Presenilin-2; PS-2; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4; PS2; PSNL2; STM2
 Product Gene Name   

anti-PSEN2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    L43964 mRNA
 3D Structure    ModBase 3D Structure for P49810
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Presenilin-2 protein (7-77AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PSEN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PSEN2 antibody

   Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
 Applications Tested/Suitable for anti-PSEN2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PSEN2 antibody    WB: 1:500-1:5000
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 Western Blot (WB) of anti-PSEN2 antibody    Western Blot
Positive WB detected in: Rat spleen tissue,Rat lung tissue
All lanes: PSEN2 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 51,47 KDa
Observed band size: 51 KDa

anti-PSEN2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PSEN2. It may not necessarily be applicable to this product.
 NCBI GI #    156105679
 NCBI GeneID    5664
 NCBI Accession #    NP_000438.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000447.2 [Other Products]
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 UniProt Primary Accession #    P49810 [Other Products]
 UniProt Secondary Accession #    Q96P32; A8K8D4; B1AP21 [Other Products]
 UniProt Related Accession #    P49810 [Other Products]
 Molecular Weight    50,011 Da
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 NCBI Official Full Name    presenilin-2 isoform 1
 NCBI Official Synonym Full Names    presenilin 2
 NCBI Official Symbol    PSEN2 [Similar Products]
 NCBI Official Synonym Symbols   
AD4; PS2; AD3L; STM2; CMD1V
[Similar Products]
 NCBI Protein Information    presenilin-2
 UniProt Protein Name    Presenilin-2
 UniProt Synonym Protein Names   
AD3LP; AD5; E5-1; STM-2
 Protein Family    Presenilin
 UniProt Gene Name    PSEN2 [Similar Products]
 UniProt Synonym Gene Names    AD4; PS2; PSNL2; STM2; PS-2 [Similar Products]
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 NCBI Summary for PSEN2    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PSEN2    PSEN2: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). An integral membrane protein of the Golgi and endoplasmic reticulum. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Two alternative splice isoforms have been identified.

Protein type: Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: apical plasma membrane; cell cortex; cell soma; centrosome; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; kinetochore; membrane; nuclear inner membrane; perinuclear region of cytoplasm; plasma membrane; protein complex; Z disc

Molecular Function: endopeptidase activity; protein binding

Biological Process: amyloid precursor protein catabolic process; beta-amyloid metabolic process; calcium ion transport; ephrin receptor signaling pathway; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; protein processing

Disease: Alzheimer Disease 4; Cardiomyopathy, Dilated, 1v
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 Research Articles on PSEN2    1. Familial Alzheimer's disease Patients with PSEN2 mutations have a delayed AOO with longest disease duration and presented more frequently with disorientation. [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PSEN2 antibodyPathways associated with anti-PSEN2 antibody
 Reference Product  PubMed Publications
 APP antibody  >251 publications with PSEN2 and APP
 NOTCH1 antibody  >14 publications with PSEN2 and NOTCH1
 PSENEN antibody  >12 publications with PSEN2 and PSENEN
 APH1A antibody  >10 publications with PSEN2 and APH1A
 NCSTN antibody  >5 publications with PSEN2 and NCSTN
 UBQLN1 antibody  >4 publications with PSEN2 and UBQLN1
 NOTCH3 antibody  >3 publications with PSEN2 and NOTCH3
 SRI antibody  >2 publications with PSEN2 and SRI
 FHL2 antibody  >2 publications with PSEN2 and FHL2
 KCNIP4 antibody  >1 publications with PSEN2 and KCNIP4
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
Diseases associated with anti-PSEN2 antibodyOrgans/Tissues associated with anti-PSEN2 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >35 publications with PSEN2 and Disease Models, Animal
 Memory Disorders Antibodies  >20 publications with PSEN2 and Memory Disorders
 Movement Disorders Antibodies  >16 publications with PSEN2 and Movement Disorders
 Cognition Disorders Antibodies  >15 publications with PSEN2 and Cognition Disorders
 Carcinoma Antibodies  >14 publications with PSEN2 and Carcinoma
 Nerve Degeneration Antibodies  >11 publications with PSEN2 and Nerve Degeneration
 Inflammation Antibodies  >10 publications with PSEN2 and Inflammation
 Necrosis Antibodies  >9 publications with PSEN2 and Necrosis
 Congenital Abnormalities Antibodies  >9 publications with PSEN2 and Congenital Abnormalities
 Weight Loss Antibodies  >8 publications with PSEN2 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >235 publications with PSEN2 and Brain
 Blood Antibodies  >33 publications with PSEN2 and Blood
 Kidney Antibodies  >24 publications with PSEN2 and Kidney
 Vascular Antibodies  >13 publications with PSEN2 and Vascular
 Muscle Antibodies  >11 publications with PSEN2 and Muscle
 Embryonic Tissue Antibodies  >10 publications with PSEN2 and Embryonic Tissue
 Liver Antibodies  >10 publications with PSEN2 and Liver
 Heart Antibodies  >8 publications with PSEN2 and Heart
 Eye Antibodies  >5 publications with PSEN2 and Eye
 Skin Antibodies  >4 publications with PSEN2 and Skin
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