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anti-PSMA3 antibody :: Rabbit PSMA3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7048955
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSMA3, Polyclonal Antibody

★Popular Item★
 Also Known As   

PSMA3 Antibody

 Product Synonym Names    Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8; PSMA3; HC8; PSC8
 Product Gene Name   

anti-PSMA3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    D00762 mRNA
 3D Structure    ModBase 3D Structure for P25788
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Proteasome subunit alpha type-3 protein (218-248AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-54670 / sc-54707 / sc-67340
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PSMA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PSMA3 antibody

   The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
 Applications Tested/Suitable for anti-PSMA3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-PSMA3 antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-PSMA3 antibody    Western Blot
Positive WB detected in: A549 whole cell lysate,PC3 whole cell lysate,NIH/3T3 whole cell lysate,Hela whole cell lysate,Rat lung tissue,Mouse liver tissue
All lanes: PSMA3 antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 29,28 KDa
Observed band size: 29 KDa

anti-PSMA3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PSMA3 antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7048955 at dilution of 1:100
anti-PSMA3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PSMA3 antibody    Immunofluorescent analysis of Hela cells using MBS7048955 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PSMA3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PSMA3. It may not necessarily be applicable to this product.
 NCBI GI #    4506183
 NCBI GeneID    5684
 NCBI Accession #    NP_002779.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002788.3 [Other Products]
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 UniProt Primary Accession #    P25788 [Other Products]
 UniProt Secondary Accession #    Q86U83; Q8N1D8; Q9BS70; B2RCK6 [Other Products]
 UniProt Related Accession #    P25788 [Other Products]
 Molecular Weight    27,647 Da
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 NCBI Official Full Name    proteasome subunit alpha type-3 isoform 1
 NCBI Official Synonym Full Names    proteasome subunit alpha 3
 NCBI Official Symbol    PSMA3 [Similar Products]
 NCBI Official Synonym Symbols   
HC8; PSC3
[Similar Products]
 NCBI Protein Information    proteasome subunit alpha type-3
 UniProt Protein Name    Proteasome subunit alpha type-3
 UniProt Synonym Protein Names   
Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8
 Protein Family    Phenol-soluble modulin alpha 3 peptide
 UniProt Gene Name    PSMA3 [Similar Products]
 UniProt Synonym Gene Names    HC8; PSC8 [Similar Products]
 UniProt Entry Name    PSA3_HUMAN
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 NCBI Summary for PSMA3    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PSMA3    PSMA3: a proteasomal protein of the T1A peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Two alternatively spliced isoforms have been identified.

Protein type: EC 3.4.25.1; Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 14q23

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex

Molecular Function: protein binding

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of endopeptidase activity; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
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 Research Articles on PSMA3    1. Our results provide evidence on new T1DM-susceptible loci in the PSMA3, PSMA6 and PSMC6 proteasome genes and give a new insight into the T1DM pathogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PSMA3 antibodyPathways associated with anti-PSMA3 antibody
 Reference Product  PubMed Publications
 PSMA6 antibody  >10 publications with PSMA3 and PSMA6
 PSMA1 antibody  >8 publications with PSMA3 and PSMA1
 PSMA5 antibody  >7 publications with PSMA3 and PSMA5
 PSMB5 antibody  >6 publications with PSMA3 and PSMB5
 PSMB2 antibody  >4 publications with PSMA3 and PSMB2
 PSMA7 antibody  >4 publications with PSMA3 and PSMA7
 PSMA2 antibody  >4 publications with PSMA3 and PSMA2
 PSMA4 antibody  >4 publications with PSMA3 and PSMA4
 PSMB3 antibody  >2 publications with PSMA3 and PSMB3
 PSMB6 antibody  >2 publications with PSMA3 and PSMB6
 Products by Pathway  Pathway Diagram
 ABC Transporter Disorders Pathway antibodies  ABC Transporter Disorders Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
Diseases associated with anti-PSMA3 antibodyOrgans/Tissues associated with anti-PSMA3 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >3 publications with PSMA3 and Lung Diseases
 Liver Diseases Antibodies  >3 publications with PSMA3 and Liver Diseases
 Hepatitis Antibodies  >2 publications with PSMA3 and Hepatitis
 Lung Neoplasms Antibodies  >2 publications with PSMA3 and Lung Neoplasms
 Liver Neoplasms Antibodies  >2 publications with PSMA3 and Liver Neoplasms
 Necrosis Antibodies  >2 publications with PSMA3 and Necrosis
 Muscular Diseases Antibodies  >1 publications with PSMA3 and Muscular Diseases
 Neoplasm Metastasis Antibodies  >1 publications with PSMA3 and Neoplasm Metastasis
 Urinary Bladder Neoplasms Antibodies  >1 publications with PSMA3 and Urinary Bladder Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with PSMA3 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with PSMA3 and Blood
 Liver Antibodies  >4 publications with PSMA3 and Liver
 Vascular Antibodies  >2 publications with PSMA3 and Vascular
 Lung Antibodies  >2 publications with PSMA3 and Lung
 Mouth Antibodies  >1 publications with PSMA3 and Mouth
 Heart Antibodies  >1 publications with PSMA3 and Heart
 Eye Antibodies  >1 publications with PSMA3 and Eye
 Bladder Antibodies  >1 publications with PSMA3 and Bladder
 Brain Antibodies  >1 publications with PSMA3 and Brain
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