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anti-PSMD12 antibody :: Rabbit anti-Human PSMD12 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7046030
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSMD12, Polyclonal Antibody

★Popular Item★
 Also Known As   

PSMD12 Antibody

 Product Synonym Names    26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55; PSMD12
 Product Gene Name   

anti-PSMD12 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604450
 3D Structure    ModBase 3D Structure for O00232
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human 26S proteasome non-ATPase regulatory subunit 12 protein (C-260AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107976
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PSMD12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PSMD12 antibody

   Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
 Applications Tested/Suitable for anti-PSMD12 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-PSMD12 antibody    Western blot
All lanes:  PSMD12antibody at 0.93ug/ml
Lane 1 : U87 whole cell lysate
Lane 2 : Hela whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 53,51 kDa
Observed band size: 53 kDa

anti-PSMD12 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PSMD12 antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7046030 at dilution 1:100
anti-PSMD12 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PSMD12. It may not necessarily be applicable to this product.
 NCBI GI #    939106604
 NCBI GeneID    5718
 NCBI Accession #    NP_001303270.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001316341.1 [Other Products]
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 UniProt Primary Accession #    O00232 [Other Products]
 UniProt Secondary Accession #    Q53HA2; Q6P053; A6NP15 [Other Products]
 UniProt Related Accession #    O00232 [Other Products]
 Molecular Weight    50,579 Da
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 NCBI Official Full Name    26S proteasome non-ATPase regulatory subunit 12 isoform 3
 NCBI Official Synonym Full Names    proteasome 26S subunit, non-ATPase 12
 NCBI Official Symbol    PSMD12 [Similar Products]
 NCBI Official Synonym Symbols   
p55; Rpn5
[Similar Products]
 NCBI Protein Information    26S proteasome non-ATPase regulatory subunit 12
 UniProt Protein Name    26S proteasome non-ATPase regulatory subunit 12
 UniProt Synonym Protein Names   
26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55
 Protein Family    26S proteasome non-ATPase regulatory
 UniProt Gene Name    PSMD12 [Similar Products]
 UniProt Entry Name    PSD12_HUMAN
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 NCBI Summary for PSMD12    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
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 UniProt Comments for PSMD12    PSMD12: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit p55 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; proteasome complex; proteasome regulatory particle

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PSMD12 antibodyDiseases associated with anti-PSMD12 antibody
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >3 publications with PSMD12 and Liver Diseases
 Carcinoma Antibodies  >1 publications with PSMD12 and Carcinoma
 Fatty Liver Antibodies  >1 publications with PSMD12 and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >1 publications with PSMD12 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with PSMD12 and Liver Neoplasms
Organs/Tissues associated with anti-PSMD12 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with PSMD12 and Liver
 Kidney Antibodies  >1 publications with PSMD12 and Kidney
 Brain Antibodies  >1 publications with PSMD12 and Brain
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