NP_001310336.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 29 kDa Predicted: 30 kDa
NCBI Official Full Name
proteasome inhibitor PI31 subunit isoform 3
NCBI Official Synonym Full Names
proteasome inhibitor subunit 1
NCBI Official Synonym Symbols
NCBI Protein Information
proteasome inhibitor PI31 subunit
UniProt Protein Name
Proteasome inhibitor PI31 subunit
UniProt Synonym Gene Names
NCBI Summary for PSMF1
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PSMF1
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Research Articles on PSMF1
Precautions
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Disclaimer
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Pathways associated with anti-PSMF1 antibody
Diseases associated with anti-PSMF1 antibody
Organs/Tissues associated with anti-PSMF1 antibody
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