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anti-PTEN antibody :: Rabbit PTEN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9406866
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTEN, Polyclonal Antibody

 Also Known As   

PTEN(Phospho-Ser380) Antibody

 Product Synonym Names    BZS, DEC, GLM2, MHAM, TEP1
 Product Gene Name   

anti-PTEN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137800
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide-KLH
 Modification    Phospho-Ser380
 Target Name    PTEN
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-PTEN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PTEN antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-PTEN antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunofluorescence (IF) of anti-PTEN antibody    Immunofluorescence staining of methanol-fixed HeLa cells using PTEN (phospho-Ser380) antibody (, Red).
anti-PTEN antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-PTEN antibody    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PTEN (phospho-Ser380) antibody ().
anti-PTEN antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PTEN. It may not necessarily be applicable to this product.
 NCBI GI #    4240387
 NCBI GeneID    5728
 NCBI Accession #    AAD13528.1 [Other Products]
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 UniProt Secondary Accession #    O00633; O02679; Q6ICT7; B2R904; F2YHV0 [Other Products]
 UniProt Related Accession #    P60484 [Other Products]
 Molecular Weight    19,796 Da
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 NCBI Official Full Name    PTEN
 NCBI Official Synonym Full Names    phosphatase and tensin homolog
 NCBI Official Symbol    PTEN [Similar Products]
 NCBI Official Synonym Symbols   
BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del
[Similar Products]
 NCBI Protein Information    phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 UniProt Protein Name    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
 UniProt Synonym Protein Names   
Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog
 Protein Family    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase
 UniProt Gene Name    PTEN [Similar Products]
 UniProt Synonym Gene Names    MMAC1; TEP1 [Similar Products]
 UniProt Entry Name    PTEN_HUMAN
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 NCBI Summary for PTEN    This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
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 UniProt Comments for PTEN    PTEN: a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability.

Protein type: Motility/polarity/chemotaxis; Phosphatase, lipid; Carbohydrate Metabolism - inositol phosphate; Nuclear receptor co-regulator; Tumor suppressor; EC 3.1.3.48; EC 3.1.3.67; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: nucleoplasm; postsynaptic membrane; PML body; neuron projection; internal side of plasma membrane; cell projection; mitochondrion; cytoplasm; extracellular region; plasma membrane; dendritic spine; nucleus; cytosol

Molecular Function: phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; platelet-derived growth factor receptor binding; magnesium ion binding; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity; protein kinase binding; PDZ domain binding; protein binding; enzyme binding; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; lipid binding; phosphoprotein phosphatase activity

Biological Process: male mating behavior; central nervous system development; prepulse inhibition; nerve growth factor receptor signaling pathway; heart development; regulation of cellular component size; response to arsenic; anaphase-promoting complex activation during mitotic cell cycle; Wnt receptor signaling pathway through beta-catenin; T cell receptor signaling pathway; regulation of B cell apoptosis; myelin maintenance in the central nervous system; response to glucose stimulus; negative regulation of axonogenesis; response to drug; rhythmic synaptic transmission; fibroblast growth factor receptor signaling pathway; dentate gyrus development; negative regulation of myelination; social behavior; negative regulation of organ growth; forebrain morphogenesis; response to ethanol; response to zinc ion; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; endothelial cell migration; positive regulation of transcription factor activity; multicellular organismal response to stress; negative regulation of apoptosis; negative regulation of phagocytosis; synapse maturation; inositol phosphate metabolic process; apoptosis; regulation of protein stability; locomotory behavior; platelet-derived growth factor receptor signaling pathway; negative regulation of cell size; regulation of myeloid cell apoptosis; protein amino acid dephosphorylation; response to estradiol stimulus; locomotor rhythm; negative regulation of cell proliferation; synaptogenesis; learning and/or memory; negative regulation of protein amino acid phosphorylation; phospholipid metabolic process; positive regulation of cell proliferation; brain morphogenesis; protein kinase B signaling cascade; nerve-nerve synaptic transmission; angiogenesis; negative regulation of cell migration; response to nutrient; negative regulation of epithelial cell proliferation; aging; cardiac muscle development; epidermal growth factor receptor signaling pathway; cell migration; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; protein stabilization; central nervous system neuron axonogenesis; maternal behavior; negative regulation of focal adhesion formation; memory; response to ATP; cell proliferation; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; innate immune response; phosphoinositide dephosphorylation; regulation of cyclin-dependent protein kinase activity; negative regulation of phosphoinositide 3-kinase cascade

Disease: Meningioma, Familial, Susceptibility To; Melanoma, Cutaneous Malignant, Susceptibility To, 1; Thyroid Carcinoma, Follicular; Bannayan-riley-ruvalcaba Syndrome; Squamous Cell Carcinoma, Head And Neck; Cowden Syndrome 1; Prostate Cancer; Glioma Susceptibility 2; Endometrial Cancer; Vacterl Association With Hydrocephalus; Macrocephaly/autism Syndrome
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 Research Articles on PTEN    1. PTEN loss is associated with hepatocellular carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PTEN antibodyPathways associated with anti-PTEN antibody
 Reference Product  PubMed Publications
 JUN antibody  >1036 publications with PTEN and JUN
 PIK3CA antibody  >613 publications with PTEN and PIK3CA
 AKT1 antibody  >540 publications with PTEN and AKT1
 TP53 antibody  >523 publications with PTEN and TP53
 PIK3CB antibody  >55 publications with PTEN and PIK3CB
 PTK2 antibody  >45 publications with PTEN and PTK2
 PDGFRB antibody  >29 publications with PTEN and PDGFRB
 PIK3CD antibody  >11 publications with PTEN and PIK3CD
 UBC antibody  >6 publications with PTEN and UBC
 SLC9A3R1 antibody  >1 publications with PTEN and SLC9A3R1
 Products by Pathway  Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
Diseases associated with anti-PTEN antibodyOrgans/Tissues associated with anti-PTEN antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2203 publications with PTEN and Carcinoma
 Adenocarcinoma Antibodies  >1067 publications with PTEN and Adenocarcinoma
 Skin Diseases Antibodies  >966 publications with PTEN and Skin Diseases
 Breast Neoplasms Antibodies  >918 publications with PTEN and Breast Neoplasms
 Glioma Antibodies  >801 publications with PTEN and Glioma
 Disease Progression Antibodies  >789 publications with PTEN and Disease Progression
 Prostatic Neoplasms Antibodies  >753 publications with PTEN and Prostatic Neoplasms
 Endometrial Neoplasms Antibodies  >525 publications with PTEN and Endometrial Neoplasms
 Neoplasm Metastasis Antibodies  >486 publications with PTEN and Neoplasm Metastasis
 Ovarian Neoplasms Antibodies  >419 publications with PTEN and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1244 publications with PTEN and Brain
 Prostate Antibodies  >1027 publications with PTEN and Prostate
 Blood Antibodies  >825 publications with PTEN and Blood
 Lung Antibodies  >628 publications with PTEN and Lung
 Vascular Antibodies  >544 publications with PTEN and Vascular
 Liver Antibodies  >520 publications with PTEN and Liver
 Muscle Antibodies  >423 publications with PTEN and Muscle
 Thyroid Antibodies  >364 publications with PTEN and Thyroid
 Skin Antibodies  >363 publications with PTEN and Skin
 Bone Antibodies  >300 publications with PTEN and Bone
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