AF208850
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,367 Da
NCBI Official Full Name
Homo sapiens BM-008 mRNA, complete cds
NCBI Official Synonym Full Names
protein tyrosine phosphatase type IVA, member 2
NCBI Official Synonym Symbols
HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b [Similar Products]
NCBI Protein Information
protein tyrosine phosphatase type IVA 2
UniProt Protein Name
Protein tyrosine phosphatase type IVA 2
UniProt Synonym Protein Names
HU-PP-1; OV-1; PTP(CAAXII); Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2
UniProt Synonym Gene Names
NCBI Summary for PTP4A2
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
UniProt Comments for PTP4A2
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Product References and Citations for anti-PTP4A2 antibody
(1) Wang, Y., Li, Z.F., He, J., et al. Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis. Int J Colorectal Dis 22 (10), 1179-1184 (2007).
Research Articles on PTP4A2
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Products associated with anti-PTP4A2 antibody
Pathways associated with anti-PTP4A2 antibody
Diseases associated with anti-PTP4A2 antibody
Organs/Tissues associated with anti-PTP4A2 antibody
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