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anti-PTPN11 antibody :: Rabbit PTPN11 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126592
Western Blot (WB)
Unit / Price
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTPN11, Polyclonal Antibody

 Also Known As   

PTPN11 Polyclonal Antibody

 Product Synonym Names    SHP2: BPTP3; CFC; MGC14433; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
 Product Gene Name   

anti-PTPN11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 607785
 3D Structure    ModBase 3D Structure for Q06124
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human PTPN11
 Calculated Molecular Weight    68kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-PTPN11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PTPN11 antibody

   PTPN11(protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism(PMID:19017799). Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions(PMID:21576358). Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1), Noonan syndrome type 1 (NS1), juvenile myelomonocytic leukemia (JMML) and metachondromatosis (MC). It has 3 isoforms produced by alternative splicing. This antibody is specific to PTPN11.
 Product Categories/Family for anti-PTPN11 antibody    Polyclonal
 Applications Tested/Suitable for anti-PTPN11 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-PTPN11 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:20 - 1:50
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 Western Blot (WB) of anti-PTPN11 antibody    Western blot analysis of extracts of Jurkat cells, using PTPN11 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-PTPN11 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PTPN11. It may not necessarily be applicable to this product.
 NCBI GI #    84028248
 NCBI GeneID    5781
 NCBI Accession #    Q06124.2 [Other Products]
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 UniProt Primary Accession #    Q06124 [Other Products]
 UniProt Secondary Accession #    Q96HD7; A8K1D9 [Other Products]
 UniProt Related Accession #    Q06124 [Other Products]
 Molecular Weight    597
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 NCBI Official Full Name    Tyrosine-protein phosphatase non-receptor type 11
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 11
 NCBI Official Symbol    PTPN11 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 11; PTP-2C; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 11
 UniProt Synonym Protein Names   
Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3
 Protein Family    Tyrosine-protein phosphatase non-receptor
 UniProt Gene Name    PTPN11 [Similar Products]
 UniProt Synonym Gene Names    PTP2C; SHPTP2; PTP-1D; PTP-2C; SHP-2; Shp2 [Similar Products]
 UniProt Entry Name    PTN11_HUMAN
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 NCBI Summary for PTPN11    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for PTPN11    SHP-2: a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: protein domain specific binding; protein binding; phospholipase binding; peptide hormone receptor binding; SH3/SH2 adaptor activity; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; phosphoprotein phosphatase activity; D1 dopamine receptor binding; insulin receptor binding

Biological Process: axon guidance; hormone-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPK activity; heart development; platelet-derived growth factor receptor signaling pathway; glucose homeostasis; positive regulation of mitotic cell cycle; reproductive process in a multicellular organism; negative regulation of insulin secretion; regulation of protein export from nucleus; regulation of cell adhesion mediated by integrin; ephrin receptor signaling pathway; abortive mitotic cell cycle; negative regulation of cell adhesion mediated by integrin; inner ear development; epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of growth hormone secretion; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cytokine and chemokine mediated signaling pathway; positive regulation of hormone secretion; regulation of multicellular organism growth; negative regulation of cortisol secretion; organ growth; genitalia development; triacylglycerol metabolic process; DNA damage checkpoint; T cell costimulation; insulin receptor signaling pathway; innate immune response; hormone metabolic process; platelet formation; brain development; blood coagulation; leukocyte migration

Disease: Metachondromatosis; Noonan Syndrome 1; Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1
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 Research Articles on PTPN11    1. This finding not only provides an alternative mechanism for how CagA and ROS coregulate SHP2 activation but may also explain their roles in H. pylori-induced IFN-gamma resistance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PTPN11 antibodyDiseases associated with anti-PTPN11 antibody
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Noonan Syndrome Antibodies  >374 publications with PTPN11 and Noonan Syndrome
 Heart Diseases Antibodies  >361 publications with PTPN11 and Heart Diseases
 Leukemia Antibodies  >277 publications with PTPN11 and Leukemia
 LEOPARD Syndrome Antibodies  >129 publications with PTPN11 and LEOPARD Syndrome
 Leukemia, Myelomonocytic, Juvenile Antibodies  >94 publications with PTPN11 and Leukemia, Myelomonocytic, Juvenile
 Carcinoma Antibodies  >84 publications with PTPN11 and Carcinoma
 Inflammation Antibodies  >65 publications with PTPN11 and Inflammation
 Costello Syndrome Antibodies  >46 publications with PTPN11 and Costello Syndrome
 Adenocarcinoma Antibodies  >42 publications with PTPN11 and Adenocarcinoma
 Disease Models, Animal Antibodies  >39 publications with PTPN11 and Disease Models, Animal
Organs/Tissues associated with anti-PTPN11 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >424 publications with PTPN11 and Blood
 Heart Antibodies  >187 publications with PTPN11 and Heart
 Bone Antibodies  >131 publications with PTPN11 and Bone
 Muscle Antibodies  >115 publications with PTPN11 and Muscle
 Bone Marrow Antibodies  >101 publications with PTPN11 and Bone Marrow
 Brain Antibodies  >100 publications with PTPN11 and Brain
 Liver Antibodies  >65 publications with PTPN11 and Liver
 Skin Antibodies  >57 publications with PTPN11 and Skin
 Nerve Antibodies  >55 publications with PTPN11 and Nerve
 Stomach Antibodies  >53 publications with PTPN11 and Stomach
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