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anti-PTPN11 antibody :: Rabbit anti-Human, Mouse PTPN11 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7049587
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTPN11, Polyclonal Antibody

★Popular Item★
 Also Known As   

PTPN11 Antibody

 Product Synonym Names    Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3; PTPN11; PTP2C; SHPTP2
 Product Gene Name   

anti-PTPN11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    D13540 mRNA
 3D Structure    ModBase 3D Structure for Q06124
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Tyrosine-protein phosphatase non-receptor type 11 protein (246-520AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-280 / sc-30687 / sc-30688 / sc-30689 / sc-424
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PTPN11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTPN11 antibody

   Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed: 26742426).
 Applications Tested/Suitable for anti-PTPN11 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PTPN11 antibody    WB: 1: 500-1: 5000
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 Western Blot (WB) of anti-PTPN11 antibody    Western Blot
Positive WB detected in:HEK293 whole cell lysate,Mouse liver tissue,Mouse lung tissue
All lanes: PTPN11 antibody at 2.8ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69,53 kDa
Observed band size: 69 kDa

anti-PTPN11 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PTPN11. It may not necessarily be applicable to this product.
 NCBI GI #    1059433492
 NCBI GeneID    5781
 NCBI Accession #    NP_001317366.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001330437.1 [Other Products]
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 UniProt Primary Accession #    Q06124 [Other Products]
 UniProt Secondary Accession #    Q96HD7; A8K1D9 [Other Products]
 UniProt Related Accession #    Q06124 [Other Products]
 Molecular Weight    52,828 Da
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 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type 11 isoform 3
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 11
 NCBI Official Symbol    PTPN11 [Similar Products]
 NCBI Official Synonym Symbols   
CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 11
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 11
 UniProt Synonym Protein Names   
Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3
 Protein Family    Tyrosine-protein phosphatase non-receptor
 UniProt Gene Name    PTPN11 [Similar Products]
 UniProt Synonym Gene Names    PTP2C; SHPTP2; PTP-1D; PTP-2C; SHP-2; Shp2 [Similar Products]
 UniProt Entry Name    PTN11_HUMAN
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 NCBI Summary for PTPN11    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
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 UniProt Comments for PTPN11    SHP-2: a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines.

Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: 1-phosphatidylinositol-3-kinase activity; insulin receptor binding; non-membrane spanning protein tyrosine phosphatase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; SH3/SH2 adaptor activity

Biological Process: brain development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; genitalia development; heart development; inner ear development; leukocyte migration; phosphoinositide-mediated signaling; platelet activation; regulation of cell adhesion mediated by integrin; regulation of phosphoinositide 3-kinase cascade; regulation of protein complex assembly; T cell costimulation

Disease: Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1; Metachondromatosis; Noonan Syndrome 1
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 Research Articles on PTPN11    1. SHP2 gain-of-function mutation enhances malignancy of breast carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PTPN11 antibodyPathways associated with anti-PTPN11 antibody
 Reference Product  PubMed Publications
 GRB2 antibody  >144 publications with PTPN11 and GRB2
 JAK2 antibody  >98 publications with PTPN11 and JAK2
 GAB1 antibody  >76 publications with PTPN11 and GAB1
 GAB2 antibody  >45 publications with PTPN11 and GAB2
 IRS1 antibody  >41 publications with PTPN11 and IRS1
 JAK1 antibody  >39 publications with PTPN11 and JAK1
 EGFR antibody  >39 publications with PTPN11 and EGFR
 PDGFRB antibody  >23 publications with PTPN11 and PDGFRB
 FRS2 antibody  >15 publications with PTPN11 and FRS2
 PXN antibody  >14 publications with PTPN11 and PXN
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Alpha 6 Beta 4 Signaling Pathway antibodies  Alpha 6 Beta 4 Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
Diseases associated with anti-PTPN11 antibodyOrgans/Tissues associated with anti-PTPN11 antibody
 Disease Name  Pubmed Publications
 Noonan Syndrome Antibodies  >410 publications with PTPN11 and Noonan Syndrome
 Heart Diseases Antibodies  >392 publications with PTPN11 and Heart Diseases
 Leukemia Antibodies  >309 publications with PTPN11 and Leukemia
 LEOPARD Syndrome Antibodies  >137 publications with PTPN11 and LEOPARD Syndrome
 Leukemia, Myelomonocytic, Juvenile Antibodies  >112 publications with PTPN11 and Leukemia, Myelomonocytic, Juvenile
 Carcinoma Antibodies  >86 publications with PTPN11 and Carcinoma
 Inflammation Antibodies  >67 publications with PTPN11 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >57 publications with PTPN11 and Cell Transformation, Neoplastic
 Costello Syndrome Antibodies  >49 publications with PTPN11 and Costello Syndrome
 Adenocarcinoma Antibodies  >44 publications with PTPN11 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >411 publications with PTPN11 and Blood
 Heart Antibodies  >187 publications with PTPN11 and Heart
 Bone Antibodies  >144 publications with PTPN11 and Bone
 Bone Marrow Antibodies  >112 publications with PTPN11 and Bone Marrow
 Muscle Antibodies  >92 publications with PTPN11 and Muscle
 Brain Antibodies  >88 publications with PTPN11 and Brain
 Liver Antibodies  >70 publications with PTPN11 and Liver
 Skin Antibodies  >66 publications with PTPN11 and Skin
 Stomach Antibodies  >50 publications with PTPN11 and Stomach
 Nerve Antibodies  >49 publications with PTPN11 and Nerve
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