P18433.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Receptor-type tyrosine-protein phosphatase alpha
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type A
NCBI Official Synonym Symbols
LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha [Similar Products]
NCBI Protein Information
receptor-type tyrosine-protein phosphatase alpha
UniProt Protein Name
Receptor-type tyrosine-protein phosphatase alpha
UniProt Synonym Gene Names
PTPA; PTPRL2; Protein-tyrosine phosphatase alpha; R-PTP-alpha [Similar Products]
NCBI Summary for PTPRA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for PTPRA
PTPRA: a receptor protein tyrosine phosphatase (PTP). Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. Dephosphorylates and activates Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Four alternatively spliced isoforms have been reported.
Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: protein binding; protein tyrosine phosphatase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor protein tyrosine phosphatase activity
Biological Process: axon guidance; MAPKKK cascade
Research Articles on PTPRA
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Products associated with anti-PTPRA antibody
Pathways associated with anti-PTPRA antibody
Diseases associated with anti-PTPRA antibody
Organs/Tissues associated with anti-PTPRA antibody
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