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anti-PTPRS antibody :: anti-Rat PTPRS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9129086
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTPRS, Polyclonal Antibody

★Popular Item★
 Also Known As   

PTPRS Polyclonal Antibody

 Product Gene Name   

anti-PTPRS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601576
 3D Structure    ModBase 3D Structure for Q13332
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 Clonality    Polyclonal
 Isotype    IgG
 Species Reactivity    Rat
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 Purity/Purification    Affinity purification
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 Source    Rabbit
 Immunogen    Recombinant protein of human PTPRS
 Category    Primary Antibody
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-PTPRS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTPRS antibody

   The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
 Product Categories/Family for anti-PTPRS antibody    Polyclonal
 Applications Tested/Suitable for anti-PTPRS antibody   

Western Blot (WB)

 Application Notes for anti-PTPRS antibody    WB: 1:500 - 1:2,000
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 Western Blot (WB) of anti-PTPRS antibody    Western blot analysis of extracts of rat testis, using PTPRS antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-PTPRS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PTPRS. It may not necessarily be applicable to this product.
 NCBI GI #    104487006
 NCBI GeneID    5802
 NCBI Accession #    NP_002841.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002850.3 [Other Products]
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 UniProt Primary Accession #    Q13332 [Other Products]
 UniProt Secondary Accession #    O75255; O75870; Q15718; Q16341; Q2M3R7 [Other Products]
 UniProt Related Accession #    Q13332 [Other Products]
 Molecular Weight    217kDa
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 NCBI Official Full Name    receptor-type tyrosine-protein phosphatase S isoform 1
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type S
 NCBI Official Symbol    PTPRS [Similar Products]
 NCBI Official Synonym Symbols   
PTPSIGMA
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase S
 UniProt Protein Name    Receptor-type tyrosine-protein phosphatase S
 UniProt Synonym Protein Names   
Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma
 Protein Family    Receptor-type tyrosine-protein phosphatase
 UniProt Gene Name    PTPRS [Similar Products]
 UniProt Synonym Gene Names    R-PTP-S; R-PTP-sigma [Similar Products]
 UniProt Entry Name    PTPRS_HUMAN
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 NCBI Summary for PTPRS    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PTPRS    PTPRS: Interacts with LAR-interacting protein LIP.1. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine; EC 3.1.3.48; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: cell adhesion; cerebellum development; cerebral cortex development; corpus callosum development; extracellular matrix organization and biogenesis; hippocampus development; spinal cord development
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 Research Articles on PTPRS    1. Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PTPRS antibodyDiseases associated with anti-PTPRS antibody
 Products by Pathway  Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with PTPRS and Inflammation
 Cell Transformation, Neoplastic Antibodies  >3 publications with PTPRS and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >2 publications with PTPRS and Disease Models, Animal
 Immune System Diseases Antibodies  >2 publications with PTPRS and Immune System Diseases
 Genital Diseases, Male Antibodies  >1 publications with PTPRS and Genital Diseases, Male
 Neoplasm Metastasis Antibodies  >1 publications with PTPRS and Neoplasm Metastasis
 Prostatic Diseases Antibodies  >1 publications with PTPRS and Prostatic Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with PTPRS and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with PTPRS and Liver Neoplasms
 Urogenital Abnormalities Antibodies  >1 publications with PTPRS and Urogenital Abnormalities
Organs/Tissues associated with anti-PTPRS antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with PTPRS and Brain
 Nerve Antibodies  >16 publications with PTPRS and Nerve
 Blood Antibodies  >6 publications with PTPRS and Blood
 Lung Antibodies  >5 publications with PTPRS and Lung
 Embryonic Tissue Antibodies  >4 publications with PTPRS and Embryonic Tissue
 Intestine Antibodies  >3 publications with PTPRS and Intestine
 Pituitary Gland Antibodies  >3 publications with PTPRS and Pituitary Gland
 Bone Antibodies  >2 publications with PTPRS and Bone
 Heart Antibodies  >2 publications with PTPRS and Heart
 Eye Antibodies  >2 publications with PTPRS and Eye
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